15 Result(s)
within
**gyi Han
Biomedicine, general
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Article
Diatomic Fe-Co catalysts synergistically catalyze oxygen evolution reaction
The design of diatomic catalysts with uniformly dispersed metal atoms is expected to improve catalytic performance, which is conducive to the intensive comprehending of the synergistic mechanism between dual-m...
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Article
Open AccessPREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer
Colorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) exhibit...
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Article
Surface reconstruction and structural transformation of two-dimensional Ni-Fe MOFs for oxygen evolution in seawater media
As a four-electron transfer reaction, oxygen evolution reaction (OER) is limited by large overpotential and slow kinetics. Here, we in-situ synthesized two-dimensional (2D) Ni-Fe metal-organic framework nanosheet...
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Article
The d-orbital regulation of isolated manganese sites for enhanced oxygen evolution
Develo** transition metal-nitrogen-carbon materials (M-N-C) as electrocatalysts for the oxygen evolution reaction (OER) is significant for low-cost energy conversion systems. Further d-orbital adjustment of ...
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Article
Multicomponent transition metal oxides and (oxy)hydroxides for oxygen evolution
Oxygen evolution reaction (OER) is the core electrode reaction in energy-related technologies, such as electrolytic water, electrocatalytic carbon dioxide reduction, rechargeable metal-air batteries, and renew...
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Article
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
CRISPR–Cas13 systems have recently been used for targeted RNA degradation in various organisms. However, collateral degradation of bystander RNAs has limited their in vivo applications. Here, we design a dual-...
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Article
Open AccessPhospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival...
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Article
Open AccessGenetic mutations in nonsyndromic deafness patients of Chinese minority and han ethnicities in Yunnan, China
Each year in China, 30,000 babies are born with congenital hearing impairment. However, the molecular etiology of hearing impairment in the Yunnan Province population where more than 52 minorities live has not...
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Article
Open AccessTonotopic reorganization and spontaneous firing in inferior colliculus during both short and long recovery periods after noise overexposure
Noise induced injury of the cochlea causes shifts in activation thresholds and changes of frequency response in the inferior colliculus (IC). Noise overexposure also induces pathological changes in the cochlea...
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Article
Open AccessSLC26A4 gene copy number variations in Chinese patients with non-syndromic enlarged vestibular aqueduct
Many patients with enlarged vestibular aqueduct (EVA) have either only one allelic mutant of the SLC26A4 gene or lack any detectable mutation. In this study, multiplex ligation-dependent probe amplification (MLPA...
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Open AccessExtremely discrepant mutation spectrum of SLC26A4 between Chinese patients with isolated Mondini deformity and enlarged vestibular aqueduct
Mutations in SLC26A4 cause Pendred syndrome (hearing loss with goiter) or DFNB4 (non-syndromic hearing loss with inner ear malformation, such as enlarged vestibular aqueduct or Mondini deformity). The relationshi...
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Article
Open AccessPrevalence of the GJB2 IVS1+1G >A mutation in Chinese hearing loss patients with monoallelic pathogenic mutation in the coding region of GJB2
Mutations in the GJB2 gene are the most common cause of nonsyndromic recessive hearing loss in China. In about 6% of Chinese patients with severe to profound sensorineural hearing impairment, only monoallelic GJB...
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Article
Open AccessComprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in China
Every year, 30,000 babies are born with congenital hearing impairment in China. The molecular etiology of hearing impairment in the Chinese population has not been investigated thoroughly. To provide appropria...
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Article
Open AccessGJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment
Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups.
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Article
Open AccessMolecular Etiology of Hearing Impairment in Inner Mongolia: mutations in SLC26A4 gene and relevant phenotype analysis
The molecular etiology of hearing impairment in Chinese has not been thoroughly investigated. Study of GJB2 gene revealed that 30.4% of the patients with hearing loss in Inner Mongolia carried GJB2 mutations. The...
