-
Article
Visual Out-of-Distribution Detection in Open-Set Noisy Environments
The presence of noisy examples in the training set inevitably hampers the performance of out-of-distribution (OOD) detection. In this paper, we investigate a previously overlooked problem called OOD detection ...
-
Article
Diatomic Fe-Co catalysts synergistically catalyze oxygen evolution reaction
The design of diatomic catalysts with uniformly dispersed metal atoms is expected to improve catalytic performance, which is conducive to the intensive comprehending of the synergistic mechanism between dual-m...
-
Article
Open AccessPREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer
Colorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) exhibit...
-
Article
Surface reconstruction and structural transformation of two-dimensional Ni-Fe MOFs for oxygen evolution in seawater media
As a four-electron transfer reaction, oxygen evolution reaction (OER) is limited by large overpotential and slow kinetics. Here, we in-situ synthesized two-dimensional (2D) Ni-Fe metal-organic framework nanosheet...
-
Article
Open AccessAnti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer
γδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens, making them attractive candidates for CAR-T-cell therapy. Unlike αβ T cells and other immune cells, γδ T cells are...
-
Article
Open AccessEvolution of mediated memory in the digital age: tracing its path from the 1950s to 2010s
In the digital age, the relationship between human memory and media is intimate and impossible to separate. This understanding serves as the foundation for this study of mediated memory, which includes an inve...
-
Article
The d-orbital regulation of isolated manganese sites for enhanced oxygen evolution
Develo** transition metal-nitrogen-carbon materials (M-N-C) as electrocatalysts for the oxygen evolution reaction (OER) is significant for low-cost energy conversion systems. Further d-orbital adjustment of ...
-
Article
Open AccessLandscape of internal N7-methylguanosine of long non-coding RNA modifications in resistant acute myeloid leukemia
Growing evidence indicates that RNA methylation plays a fundamental role in epigenetic regulation, which is associated with the tumorigenesis and drug resistance. Among them, acute myeloid leukemia (AML), as t...
-
Article
Open AccessSurgical management and the prognosis of iatrogenic facial nerve injury in middle ear surgery: a 20-year experience
Iatrogenic facial nerve injury is one of the severest complications of middle ear surgery, this study aims to evaluate surgical management and prognosis in the era of improved surgical instruments.
-
Article
Development of miniature base editors using engineered IscB nickase
As a miniature RNA-guided endonuclease, IscB is presumed to be the ancestor of Cas9 and to share similar functions. IscB is less than half the size of Cas9 and thus more suitable for in vivo delivery. However,...
-
Article
Multicomponent transition metal oxides and (oxy)hydroxides for oxygen evolution
Oxygen evolution reaction (OER) is the core electrode reaction in energy-related technologies, such as electrolytic water, electrocatalytic carbon dioxide reduction, rechargeable metal-air batteries, and renew...
-
Article
Abductive subconcept learning
Bridging neural network learning and symbolic reasoning is crucial for strong AI. Few pioneering studies have made some progress on logical reasoning tasks that require partitioned inputs of instances (e.g., s...
-
Article
Surgical management of endolymphatic sac tumor: classification, outcomes and strategy. A single institution’s experience
To review the resections of endolymphatic sac tumor (ELST) and describe our experience in the surgical management of ELST.
-
Chapter and Conference Paper
Ethical and Pedagogical Impacts of AI in Education
Artificial Intelligence is becoming pervasive in higher education. While these tools can provide customized intervention and feedback, they may cause ethical risks and sociotechnical implications. Current ethi...
-
Article
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
CRISPR–Cas13 systems have recently been used for targeted RNA degradation in various organisms. However, collateral degradation of bystander RNAs has limited their in vivo applications. Here, we design a dual-...
-
Article
Adaptive Energy Management Strategy of Fuel Cell Electric Vehicle
The energy management strategy (EMS) can efficiently split the power among different sources for a fuel cell electric vehicle (FCEV). This paper puts forward how to cooperate with a proton exchange membrane fu...
-
Article
Petrous bone cholesteatoma: our experience of 20 years and management of two giant cases affecting rhinopharynx
To demonstrate our experience in the treatment of petrous bone cholesteatoma (PBC).
-
Chapter and Conference Paper
Research on the Application of Artificial Intelligence in Brain Functional Imaging
Magnetic resonance imaging (MRI) can directly reflect the functional activity pattern of the brain, which helps to better understand the rules of human thinking and activity patterns. It has become an importan...
-
Article
Effects of a 4-year intervention on hand hygiene compliance and incidence of healthcare associated infections: a longitudinal study
Studies have demonstrated improvements in hand hygiene (HH) compliance through interventions, noting the negative association of HH and healthcare associated infections (HAIs), but how to sustain long-term imp...
-
Article
Open AccessProtocatechuic acid attenuates isoproterenol-induced cardiac hypertrophy via downregulation of ROCK1–Sp1–PKCγ axis
Cardiac hypertrophy is an adaptive response of the myocardium to pressure overload or adrenergic agonists. Here, we investigated the protective effects and the regulatory mechanism of protocatechuic acid, a ph...
