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  1. Article

    Open Access

    Hyperoxia but not high tidal volume contributes to ventilator-induced lung injury in healthy mice

    Mechanical ventilation is a supportive therapy used to maintain respiratory function in several clinical and surgical cases but is always accompanied by lung injury risk due to improper treatment. We investiga...

    Yong Xu, Yu Li, Da Zhai, Chen Yan, **gyan Liang… in BMC Pulmonary Medicine (2023)

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  2. Article

    Talking about speaking: what do we know about language reorganization in brain tumors before surgery

    Demao Deng, Lingyan Liang in European Radiology (2023)

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  3. Article

    Open Access

    Integrative analyses of bulk microarray data to discover genes, pathways, and immune infiltration characteristics associated with targeting of Ewing sarcoma

    To explore transcriptome and immunological features of patients with Ewing sarcoma (ES) using all publicly available microarray data.

    Binjie Cao, Haijian Sun, Zhehao Fan… in Journal of Cancer Research and Clinical On… (2023)

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  4. No Access

    Article

    OSI-906 restores the sensitivity of ovarian clear cell carcinoma to cisplatin by targeting the IGF1R/AKT pathway

    Among the various histologic subtypes of ovarian cancers (OCs), ovarian clear cell carcinoma (OCCC) represents a great challenge due to its disease aggressiveness and resistance to chemotherapy. IGF1 is overex...

    Li Liu, Changyan Liang, Chenya Zhuo, Huiyun Jiang, Huixia Ye… in Medical Oncology (2022)

  5. No Access

    Article

    PARP Inhibitors

    Poly (ADP-ribose) polymerase (PARP) is a novel therapeutic target in cancer. Preclinical studies demonstrate that PARP inhibitors selectively kill BRCA-deficient cells and potentiate the effects of DNA-damaging a...

    Hongyan Liang, Antoinette R. Tan in Current Breast Cancer Reports (2011)

  6. No Access

    Article

    Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen

    We have previously used a subtractive immunization (SI) approach to generate monoclonal antibodies (mAbs) against proteins preferentially expressed by the highly metastatic human epidermoid carcinoma cell line, M

    John D Hooper, Andries Zijlstra, Ronald T. Aimes, Hongyan Liang… in Oncogene (2003)