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Article
Open AccessCausal relationship between bone mineral density and intervertebral disc degeneration: a univariate and multivariable mendelian randomization study
Although previous studies have suggested a possible association between bone mineral density (BMD) and intervertebral disc degeneration (IDD), the causal relationship between them remains unclear. Evidence fro...
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Article
Open AccessIdentification of diagnostic markers for moyamoya disease by combining bulk RNA-sequencing analysis and machine learning
Moyamoya disease (MMD) remains a chronic progressive cerebrovascular disease with unknown etiology. A growing number of reports describe the development of MMD relevant to infection or autoimmune diseases. Ide...
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Article
Open AccessThe value of indocyanine green-FLOW800 in microvasculature for predicting cerebral hyperperfusion syndrome in moyamoya disease patients
Among the notable complications of direct hemodynamic reconstruction for moyamoya disease (MMD) is cerebral hyperperfusion syndrome (CHS). In this study, we evaluated hemodynamic changes in small regional micr...
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Article
Open AccessPRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression
Protein arginine methyltransferase 2 (PRMT2) is involved in several biological processes via histone methylation and transcriptional regulation. Although PRMT2 has been reported to affect breast cancer and gli...
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Article
Open AccessTargeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer
Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) help tumor cells evade immune surveillance, and are regarded as important targets of anti-tumor immunotherapy. Post-translational modi...
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Article
Open AccessNormalization of tumor markers and a clear resection margin affect progression-free survival of patients with unresectable pancreatic cancer who have undergone conversion surgery
With the advent of intensive combination regimens, an increasing number of patients with unresectable pancreatic cancer (UPC) have regained the opportunity for surgery. We investigated the clinical benefits an...
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Article
Open AccessInsights into the deriving of rhizosphere microenvironments and its effects on the growth of authentic Angelica sinensis seedlings under continuous monoculture
Continuous monoculture leads to deterioration of soil microenvironment, which can severely threat the quality and efficiency of Angelica sinensis (A. sinensis), especially for seedlings production. However, littl...
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Article
Open AccessResearch on the effectiveness of a intersection risk warning system based on driving simulation experiment
In order to improve the traffic safety condition of intersections, a real-time traffic conflict risk warning system (RTCRWS) is proposed for uncontrolled intersections. To evaluate the effectiveness of this sy...
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Article
Open AccessA clinical and biomechanical comparison of INFIX plus single versus double sacroiliac screw fixation for unstable pelvic ring injury
The aim of this study is to compare the clinical and biomechanical outcome of INFIX plus single with two sacroiliac screw fixation for unstable pelvic fractures of Type C.
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Article
Open AccessA myxozoan genome reveals mosaic evolution in a parasitic cnidarian
Parasite evolution has been conceptualized as a process of genetic loss and simplification. Contrary to this model, there is evidence of expansion and conservation of gene families related to essential functio...
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Article
Open AccessCombination therapy for pancreatic cancer: anti-PD-(L)1-based strategy
Mortality associated with pancreatic cancer is among the highest of all malignancies, with a 5-year overall survival of 5–10%. Immunotherapy, represented by the blocking antibodies against programmed cell deat...
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Article
Open AccessNEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains poorly defined. Here, we de...
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Article
Open AccessRegulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells
Therapeutic strategies to treat pancreatic ductal adenocarcinoma (PDAC) remain unsatisfying and limited. Therefore, it is imperative to fully determine the mechanisms underlying PDAC progression. In the presen...
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Article
Open AccessA preoperative nomogram predicts prognosis of patients with hepatocellular carcinoma after liver transplantation: a multicenter retrospective study
Although criteria for liver transplantation, such as the Milan criteria and Hangzhou experiences, have become popular, criteria to guide adjuvant therapy for patients with hepatocellular carcinoma after liver ...
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Article
Open AccessThe AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination
Despite recent progress in hepatitis treatment, there have been no significant advances in the development of liver cancer vaccines in recent years. In this study, we investigated the regulatory effect and pot...
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Chapter and Conference Paper
Machine Learning Assisted Optical Network Resource Scheduling in Data Center Networks
Parallel computing allows us to process incredible amounts of data in a timely manner by distributing the workload across multiple nodes and executing computation simultaneously. However, the performance of t...
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Article
Open AccessClassification, Synthesis, and Application of Luminescent Silica Nanoparticles: a Review
Luminescent materials are of worldwide interest because of their unique optical properties. Silica, which is transparent to light, is an ideal matrix for luminescent materials. Luminescent silica nanoparticles...
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Article
Open AccessMorphological plasticity in Myxobolus Bütschli, 1882: a taxonomic dilemma case and renaming of a parasite species of the common carp
Myxozoans are a group of cnidarian parasites, the present taxonomy of which favors a more comprehensive characterization strategy combining spore morphology, biological traits (host/organ specificity, tissue t...
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Article
Open AccessStarving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors
Calorie restriction (CR) prevents obesity and exerts anticancer effects in many preclinical models. CR is also increasingly being used in cancer patients as a sensitizing strategy prior to chemotherapy regimen...
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Article
Open AccessReprogramming of Seed Metabolism Facilitates Pre-harvest Sprouting Resistance of Wheat
Pre-harvest sprouting (PHS) is a worldwide problem for wheat production and transgene antisense-thioredoxin-s (anti-trx-s) facilitates outstanding resistance. To understand the molecular details of PHS resistance...
