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Article
Open AccessIdentification of diagnostic markers for moyamoya disease by combining bulk RNA-sequencing analysis and machine learning
Moyamoya disease (MMD) remains a chronic progressive cerebrovascular disease with unknown etiology. A growing number of reports describe the development of MMD relevant to infection or autoimmune diseases. Ide...
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Article
Open AccessThe value of indocyanine green-FLOW800 in microvasculature for predicting cerebral hyperperfusion syndrome in moyamoya disease patients
Among the notable complications of direct hemodynamic reconstruction for moyamoya disease (MMD) is cerebral hyperperfusion syndrome (CHS). In this study, we evaluated hemodynamic changes in small regional micr...
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Article
Open AccessResearch on the effectiveness of a intersection risk warning system based on driving simulation experiment
In order to improve the traffic safety condition of intersections, a real-time traffic conflict risk warning system (RTCRWS) is proposed for uncontrolled intersections. To evaluate the effectiveness of this sy...
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Article
Open AccessNEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains poorly defined. Here, we de...
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Article
Open AccessReprogramming of Seed Metabolism Facilitates Pre-harvest Sprouting Resistance of Wheat
Pre-harvest sprouting (PHS) is a worldwide problem for wheat production and transgene antisense-thioredoxin-s (anti-trx-s) facilitates outstanding resistance. To understand the molecular details of PHS resistance...
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Article
An improved coupling reaction for the preparation of pyridylethynyl benzonitrile compounds
An improved coupling reaction between aromatic ring and acetylene triple bond catalyzed by palladium (0) catalyses for the preparation of pyridylethynyl benzonitrile compounds is described. Efforts were made t...
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Article
Enthalpy-entropy compensation in protein unfolding
Enthalpy-entropy compensation was found to be a universal law in protein unfolding based on over 3000 experimental data. Water molecular reorganization accompanying the protein unfolding was suggested as the o...