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  1. Article

    Open Access

    PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression

    Protein arginine methyltransferase 2 (PRMT2) is involved in several biological processes via histone methylation and transcriptional regulation. Although PRMT2 has been reported to affect breast cancer and gli...

    Zhongwei Li, Chaozhen Chen, Hongmei Yong, Lei Jiang, Pengfei Wang… in Cell Death & Disease (2023)

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  2. Article

    Open Access

    Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer

    Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) help tumor cells evade immune surveillance, and are regarded as important targets of anti-tumor immunotherapy. Post-translational modi...

    Hanshen Yang, **aozhen Zhang, Mengyi Lao, Kang Sun… in Cell Death & Differentiation (2023)

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  3. No Access

    Article

    Selective and novel cyclin-dependent kinases 4 inhibitor: synthesis and biological evaluation

    A series of novel LEE011 derivatives containing pyridine N-oxide were designed, synthesized and evaluated. Systematic study of the structure-activity relationship (SAR) improves the selectivity for CDK4 and le...

    Qingxiang Guo, Yongtao Li, Chao Zhang, Zhi Huang, **n Wang… in Medicinal Chemistry Research (2018)