14 Result(s)

Article

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular tr...

Yonghao Zhao, Yunshu Wang, Jiaye Yang, **n Wang… in Molecular Neurodegeneration (2012)

Article

A novel mechanism underlying pathogenesis of Down syndrome

**n Wang, Yingjun Zhao, **aofei Zhang, Ying Zhou… in Molecular Neurodegeneration (2013)

Article

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

Alzheimer disease (AD) and other tauopathies develop cerebral intracellular inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence suggests a clear link between type 2 diabetes mellit...

Erica Barini, Odetta Antico, Yingjun Zhao, Francesco Asta… in Molecular Neurodegeneration (2016)

Article

Intracellular trafficking of TREM2 is regulated by presenilin 1

Genetic mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to a variety of neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis, frontotem...

Yingjun Zhao, **aoguang Li, Timothy Huang… in Experimental & Molecular Medicine (2017)

Article

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Alzheimer’s disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear under...

Tiantian Guo, Denghong Zhang, Yuzhe Zeng, Timothy Y. Huang… in Molecular Neurodegeneration (2020)

Article

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

Aberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribut...

Qingyang Zhang, Juan Zhang, ** Ye, **aohui Li, Hongda Liu… in Molecular Neurodegeneration (2021)

Article

Tea polyphenol modified, photothermal responsive and ROS generative black phosphorus quantum dots as nanoplatforms for promoting MRSA infected wounds healing in diabetic rats

Healing of MRSA (methicillin-resistant Staphylococcus aureus) infected deep burn wounds (MIDBW) in diabetic patients remains an obstacle but is a cutting-edge research problem in clinical science. Surgical deb...

Shibo Xu, Linna Chang, Yanan Hu, **ngjun Zhao… in Journal of Nanobiotechnology (2021)

Article

Correction to: Tea polyphenol modified, photothermal responsive and ROS generative black phosphorus quantum dots as nanoplatforms for promoting MRSA infected wounds healing in diabetic rats

Shibo Xu, Linna Chang, Yanan Hu, **ngjun Zhao… in Journal of Nanobiotechnology (2022)

Article

Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease

Yingjun Zhao, Huaxi Xu in Molecular Neurodegeneration (2022)

Article

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

Microglia plays crucial roles in Alzheimer’s disease (AD) development. Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function. Here w...

Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan… in Molecular Neurodegeneration (2022)

Article

Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Targeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal proteins, RPL11 centralizes the nucleolar stress-sensing pathway by binding...

Bingwu Wang, Jian Gao, Zhongjun Zhao, Xuefei Zhong, Hao Cui, Hui Hou… in Molecular Medicine (2022)

Article

m⁶A methyltransferase METTL3 programs CD4⁺ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4⁺ T-cell activation and imbalanced effector T-cell differentiation play critical roles. Recent studies have implied a potential a...

Shuang Lu, **ngyu Wei, Huan Zhu, Zhi Hu, Meiling Zheng, Jiali Wu… in Molecular Medicine (2023)

Article

Assessment of an exhaled breath test using ultraviolet photoionization time-of-flight mass spectrometry for the monitoring of kidney transplant recipients

Continuous monitoring for immunosuppressive status, infection and complications are a must for kidney transplantation (KTx) recipients. Traditional monitoring including blood sampling and kidney biopsy, which ...

Shijian Feng, Chengfang **ang, Yushi He, Zhuoya Li, Zhongjun Zhao… in Molecular Biomedicine (2023)

Article

Functional significance of cholesterol metabolism in cancer: from threat to treatment

Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the maintenance of cellular activities. Recen...

Mingming **ao, ** Xu, Wei Wang, Bo Zhang, Jiang Liu… in Experimental & Molecular Medicine (2023)