29 Result(s)
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Smoke Plume Dynamics
Smoke plume dynamic science focuses on understanding the various smoke processes that control the movement and mixing of smoke. A current challenge facing this research is providing timely and accurate smoke i...
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The resurgent landscape of xenotransplantation of pig organs in nonhuman primates
Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed patients to die or become too sick for transplantation. Genetically engineered pigs have been discussed as a potential al...
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Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes
Advanced and metastatic tumors with complex treatment histories drive cancer mortality. Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and clinical dataset, amenable for explor...
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Conceptual Design of Screening System for Congenital Heart Disease
Congenital heart disease (CHD), one of the main causes of infant mortality, should be screened as early as possible. However, the current screening method, auscultation, strongly depends on the doctors’ experi...
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Open AccessIncreasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing
RNA-Sequencing (RNA-seq) is now commonly used to reveal quantitative spatiotemporal snapshots of the transcriptome, the structures of transcripts (splice variants and fusions) and landscapes of expressed mutation...
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Open AccessMICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70
Mitochondrial Ca2+ overload is a main contributor to mitochondrial damage hence cardiomyocyte death in myocardial ischemia/reperfusion (MI/R) injury. MICU1 has been recently identified as an important regulator o...
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Open AccessProfiling of drought-responsive microRNA and mRNA in tomato using high-throughput sequencing
Abiotic stresses cause severe loss of crop production. Among them, drought is one of the most frequent environmental stresses, which limits crop growth, development and productivity. Plant drought tolerance is...
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Erratum: Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean
Nat. Biotechnol. 33, 408–414 (2015); published online 2 February 2015; corrected after print 4 February 2016 In the version of this article initially published, grant no. 91131005 from the National Natural Sci...
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Open AccessResequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean
Resequencing of 302 soybean accessions and GWAS provide a comprehensive resource for soybean geneticists and breeders.
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Open AccessBarnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies
Chimeric transcripts, including partial and internal tandem duplications (PTDs, ITDs) and gene fusions, are important in the detection, prognosis, and treatment of human cancers.
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DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution
The Strand-seq method independently sequences each parental strand of template DNA from single proliferating cells. It can be used to detect sister chromatid exchange and other chromosomal abnormalities at hig...
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De novo assembly and analysis of RNA-seq data
The Trans-ABySS pipeline is an integrated approach for transcript assembly and analysis to identify new mRNA isoforms and structures.
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Alternative expression analysis by RNA sequencing
Alternative expression analysis by sequencing (ALEXA-seq) aligns RNA-seq reads from different cell types to a database of alternative expression sequence features and quantifies isoforms that are differentiall...
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Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
Methods for profiling DNA methylation differ in the physical principles used to detect modified cytosines. Harris et al. compare the performances of four sequencing-based technologies for genome-wide analysis of ...
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Article
Nutrition and health relevant regulation of intestinal sulfur amino acid metabolism
Sulfur amino acids (SAA), particularly methionine and cysteine, are critical for the gut to maintain its functions including the digestion, absorption and metabolism of nutrients, the immune surveillance of th...
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Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA
Twenty-two microRNAs are found to be amplified or deleted in hepatocellular carcinoma (HCC). miR-151 is encoded by an intron in the focal adhesion kinase FAK-1 gene, with which it is co-transcribed, and increases...
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Open AccessIdentification of genes expressed in the hermaphrodite germ line of C. elegans using SAGE
Germ cells must progress through elaborate developmental stages from an undifferentiated germ cell to a fully differentiated gamete. Some of these stages include exiting mitosis and entering meiosis, progressi...
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Accumulation process and model for the Ordovician buried hill reservoir in the western Lunnan area, the Tarim Basin
The Ordovician buried hill reservoir in the western Lunnan area, a type of dissolved fracture and cavernous reservoir, is mainly composed of heavy oil. The oil is the mixture sourcing from the Middle-Lower Cam...
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Open AccessA systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE)
The embryonic definitive endoderm (DE) gives rise to organs of the gastrointestinal and respiratory tract including the liver, pancreas and epithelia of the lung and colon. Understanding how DE progenitor cell...
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Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
We developed a method, ChIP-sequencing (ChIP-seq), combining chromatin immunoprecipitation (ChIP) and massively parallel sequencing to identify mammalian DNA sequences bound by transcription factors in vivo. We u...
