12 Result(s)

Article

The effect of an exercise intervention on adolescent idiopathic scoliosis: a network meta-analysis

To explore the effect of exercise intervention on adolescent idiopathic scoliosis (AIS), various exercise forms were compared and the sequence of the possibility of improving the effect of each exercise form w...

Yonghuan Chen, Zhendong Zhang, Qiuhan Zhu in Journal of Orthopaedic Surgery and Research (2023)

Article

Cylindrical Al Nano-Dimer Induced Polarization in Deep UV Region

The polarization properties of asymmetric plasmonic nanostructures originating from optical anisotropy show great application prospects in many fields, such as display, sensing, filtering, and detection. Here,...

Conghui Xu, Jianfeng Wu, Binghuan Chen, Wenyu Kang, Jun Yin… in Nanoscale Research Letters (2022)

Article

The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities

Huntington’s disease is caused by a pathologically long (>35) CAG repeat located in the first exon of the Huntingtin gene (HTT). While pathologically expanded CAG repeats are the focus of extensive investigations...

Raffaele Iennaco, Giulio Formenti, Camilla Trovesi… in Cell Death & Differentiation (2022)

Article

DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker

Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains understudied in pediatric central nervous system (CNS) tumors. 5hmC is abundant in the brain, and alterations to 5hmC in adult CNS tumors have been re...

Nasim Azizgolshani, Curtis L. Petersen, Youdinghuan Chen… in Clinical Epigenetics (2021)

Article

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks

DNA methylation (DNAm) alterations have been heavily implicated in carcinogenesis and the pathophysiology of diseases through upstream regulation of gene expression. DNAm deep-learning approaches are able to c...

Joshua J. Levy, Youdinghuan Chen… in npj Systems Biology and Applications (2021)

Article

CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro

Nucleus pulposus cell (NPC) degeneration is widely accepted as one of the major causes of intervertebral disc (IVD) degeneration (IVDD). The pathogenesis of IVDD is complex and consists of inflammation, oxidat...

**aoqiang Cheng, Jiayi Lin, Zhanghuan Chen, Yubo Mao, **exin Wu… in Molecular Medicine (2021)

Article

Double sulfur vacancies by lithium tuning enhance CO₂ electroreduction to n-propanol

Electrochemical CO₂ reduction can produce valuable products with high energy densities but the process is plagued by poor selectivities and low yields. Propanol represents a challenging product to obtain due to t...

Chen Peng, Gan Luo, Junbo Zhang, Menghuan Chen, Zhiqiang Wang… in Nature Communications (2021)

Article

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we ...

Lucía Barbier-Torres, Karen A. Fortner, Paula Iruzubieta… in Nature Communications (2020)

Article

MethylNet: an automated and modular deep learning approach for DNA methylation analysis

DNA methylation (DNAm) is an epigenetic regulator of gene expression programs that can be altered by environmental exposures, aging, and in pathogenesis. Traditional analyses that associate DNAm alterations wi...

Joshua J. Levy, Alexander J. Titus, Curtis L. Petersen… in BMC Bioinformatics (2020)

Article

Hollow Nanocages of Ni_xCo_1−xSe for Efficient Zinc–Air Batteries and Overall Water Splitting

Article

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier

BRCA1-mutated cancers exhibit deficient homologous recombination (HR) DNA repair, resulting in extensive copy number alterations and genome instability. HR deficiency can also arise in tumors without a BRCA1 muta...

Youdinghuan Chen, Yue Wang, Lucas A. Salas, Todd W. Miller… in Breast Cancer Research (2019)

Article

Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis

Lung macrophages are major participants in the pulmonary innate immune response. In the cystic fibrosis (CF) lung, the inability of lung macrophages to successfully regulate the exaggerated inflammatory respon...

Youdinghuan Chen, David A. Armstrong, Lucas A. Salas… in Clinical Epigenetics (2018)