4 Result(s)
within
**ghuan Chen
Life Sciences
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Article
Open AccessThe evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities
Huntington’s disease is caused by a pathologically long (>35) CAG repeat located in the first exon of the Huntingtin gene (HTT). While pathologically expanded CAG repeats are the focus of extensive investigations...
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Article
Open AccessMethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks
DNA methylation (DNAm) alterations have been heavily implicated in carcinogenesis and the pathophysiology of diseases through upstream regulation of gene expression. DNAm deep-learning approaches are able to c...
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Article
Open AccessMethylNet: an automated and modular deep learning approach for DNA methylation analysis
DNA methylation (DNAm) is an epigenetic regulator of gene expression programs that can be altered by environmental exposures, aging, and in pathogenesis. Traditional analyses that associate DNAm alterations wi...
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Article
The Synergic Relationship Between Xylan Removal and Enhanced Cellulose Digestibility for Bioethanol Production: Reactive Area, Crystallinity, and Inhibitation
Hemicellulosic fraction is thought to act as a barrier, preventing the access of cellulase to cellulose. The impact of xylan removal, by both of the chemical and biological processes, on the cellulose accessib...
