-
Article
Open AccessAssociations between modifiable risk factors and hepatocellular carcinoma: a trans-ancestry Mendelian randomization study
Potentially modifiable risk factors for hepatocellular carcinoma (HCC) have been investigated in observational epidemiology studies in East Asian and European populations, whereas the causal associations of mo...
-
Article
Electricity Generation Potential Forecast of Bei**g Municipal Solid Waste Separation Rate Based on GRA-BiLSTM Model
China MSW (Municipal solid waste) is being transformed from a strictly environmental problem to a renewable resource. Effective treatment of future MSW requires reliable forecasts of MSW generation, separation...
-
Article
A Robust Subpixel-Level Celestial Edge Localization Algorithm for Optical Navigation
The precise localization of celestial edges is crucial for autonomous navigation in deep space. This study proposes a high-precision subpixel-level edge localization method based on coarse and fine detection t...
-
Article
Open AccessSMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...
-
Article
Prediction of municipal solid waste generation and environmental risk assessment of heavy metal based on long short term memory
Incineration is the main measure to deal with the increasing amount of municipal solid waste (MSW) in China. However, the effective management of fly ash, which is rich in a range of heavy metals, remains a ch...
-
Article
Open AccessAssociation of depressive symptoms and sleep disturbances with survival among US adult cancer survivors
Depression and sleep disturbances are associated with increased risks of various diseases and mortality, but their impacts on mortality in cancer survivors remain unclear. The objective of this study was to ch...
-
Article
Open AccessIdentification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mut...
-
Article
Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia
The anterior cingulate cortex (ACC) is a heterogeneous region of the brain’s limbic system that regulates cognitive and emotional processing, and is frequently implicated in schizophrenia. This study aims to c...
-
Article
Advanced Machine Learning for Financial Markets: A PCA-GRU-LSTM Approach
This study pioneers the integration of environmental data with financial indicators to forecast stock prices, employing a novel PCA-GRU-LSTM model. By analyzing the Shanghai Composite (SSEC) index alongside si...
-
Article
Open AccessDeep-learning segmentation to select liver parenchyma for categorizing hepatic steatosis on multinational chest CT
Unenhanced CT scans exhibit high specificity in detecting moderate-to-severe hepatic steatosis. Even though many CTs are scanned from health screening and various diagnostic contexts, their potential for hepat...
-
Article
Open AccessPrognosis and influencing factors of ER-positive, HER2-low breast cancer patients with residual disease after neoadjuvant chemotherapy: a retrospective study
Previously, we found that patients with estrogen receptor (ER)-positive, HER2-low breast cancer are resistant to neoadjuvant chemotherapy (NACT) and have worse outcomes than those who achieve pathological comp...
-
Article
Microstructure Evolution and Properties of Nitrogen-Bearing Hypereutectic High Chromium Cast Iron after Quenching
High chromium cast iron (HCCI) is widely used in mining and metallurgy due to its high wear resistance. The purpose of this study is to reveal the effects of different quenching temperatures on the microstruct...
-
Article
Open AccessIL-1β promotes esophageal squamous cell carcinoma growth and metastasis through FOXO3A by activating the PI3K/AKT pathway
Esophageal cancer is a common type of cancer that poses a significant threat to human health. While the pro-inflammatory cytokine IL-1β has been known to contribute to the development of various types of tumor...
-
Article
Facile synthesis of Fe3O4/CoCO3 nanoparticles anchored on reduced graphene oxide for highly efficient microwave absorption
In this work, the composites comprising Fe3O4/CoCO3 nanoparticles and reduced graphene oxide (rGO) with hierarchical structure have been synthesized using a one-pot solvothermal method. The microstructure and mic...
-
Article
Cloud Removal of Full-Disk Solar H \(\alpha \) Images Based on RPix2PixHD
Clouds in the sky can significantly affect full-disk observations of the Sun. In cloud-covered full-disk H α ...
-
Article
Stock price prediction through GRA-WD-BiLSTM model with air quality and weather factors
Accurately predicting stock prices is crucial for reducing investment-related risks in decision-making. Contemporary challenges to financial behavior, posed by environmental issues such as pollution and climat...
-
Article
Open AccessWettability evaluation of shale oil reservoirs and its impact on the post-fracturing shut-in duration of horizontal wells: a quantitative study for Ordos Basin, NW China
Shale oil development in Ordos Basin, China, primarily relies on the displacement of crude oil during the post-fracturing shut-in stage (PFSIS) of horizontal wells. Reservoir wettability significantly influenc...
-
Article
Single-Ni-atoms on nitrogenated humic acid based porous carbon for CO2 electroreduction
We proposed a facile synthesis of single-Ni-atom catalysts on low-cost porous carbon using a calcination method at the temperatures of 850–1000 °C, which were used for CO2 electrochemical reduction to CO. The por...
-
Article
Open AccessA distal enhancer guides the negative selection of toxic glycoalkaloids during tomato domestication
Steroidal glycoalkaloids (SGAs) are major plant defense metabolites against pests, while they are considered poisonous in food. The genetic basis that guides negative selection of SGAs production during tomato...
-
Article
Open AccessUTRN as a potential biomarker in breast cancer: a comprehensive bioinformatics and in vitro study
Utrophin (UTRN), known as a tumor suppressor, potentially regulates tumor development and the immune microenvironment. However, its impact on breast cancer’s development and treatment remains unstudied. We con...
