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  1. No Access

    Article

    Preparation of (S)-epichlorohydrin using a novel halohydrin dehalogenase by selective conformation adjustment

    Chiral epichlorohydrin (ECH) is an attractive intermediate for chiral pharmaceuticals and chemicals preparation. The asymmetric synthesis of chiral ECH using 1,3-dicholoro-2-propanol (1,3-DCP) catalyzed by a h...

    **ao-Jian Zhang, Meng-Yu Huang, **n-**n Peng, Min Cao in Biotechnology Letters (2024)

  2. Article

    Open Access

    Deep Learning–Based Localization and Detection of Malpositioned Nasogastric Tubes on Portable Supine Chest X-Rays in Intensive Care and Emergency Medicine: A Multi-center Retrospective Study

    Malposition of a nasogastric tube (NGT) can lead to severe complications. We aimed to develop a computer-aided detection (CAD) system to localize NGTs and detect NGT malposition on portable chest X-rays (CXRs)...

    Chih-Hung Wang, Tianyu Hwang, Yu-Sen Huang in Journal of Imaging Informatics in Medicine (2024)

  3. Article

    Open Access

    Study of sex-biased differences in genomic profiles in East Asian hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is characterized by a notable sex disparity in incidence and tumor aggressiveness. Revealing differences in genetic landscapes between male and female HCCs may expand the underst...

    Chung-Yu Huang, Kien-Thiam Tan, Shiu-Feng Huang, Yen-Jung Lu in Discover Oncology (2024)

  4. No Access

    Article

    Growth and Transcriptional Regulation of Camellia sinensis Planted in Understory Mode Revealed by Transcriptomic, Metagenomic, and Machine-Vision Analyses

    Camellia sinensis is a significant economic and medical plant. The plant is short and thrives in shaded environments, making it suitable for cultivation under forest canopies. However, the mechanisms governing th...

    Jialin Liao, Shaolei Xu, Lisha Zhong in Journal of Soil Science and Plant Nutrition (2024)

  5. Article

    Open Access

    Mining the interpretable prognostic features from pathological image of intrahepatic cholangiocarcinoma using multi-modal deep learning

    The advances in deep learning-based pathological image analysis have invoked tremendous insights into cancer prognostication. Still, lack of interpretability remains a significant barrier to clinical application.

    Guang-Yu Ding, Wei-Min Tan, You-Pei Lin, Yu Ling, Wen Huang, Shu Zhang in BMC Medicine (2024)

  6. Article

    Open Access

    Engineered droplet-forming peptide as photocontrollable phase modulator for fused in sarcoma protein

    The assembly and disassembly of biomolecular condensates are crucial for the subcellular compartmentalization of biomolecules in the control of cellular reactions. Recently, a correlation has been discovered b...

    Hao-Yu Chuang, Ruei-Yu He, Yung-An Huang, Wan-Ting Hsu in Nature Communications (2024)

  7. Article

    Correction to: Association Between a Failed Prominence Eruption and the Drainage of Mass from Another Prominence

    Jian-chao Xue, Li Feng, Hui Li, ** Zhang, Jun Chen, Guang-lu Shi in Solar Physics (2024)

  8. No Access

    Article

    Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan

    Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.

    Chin-Wei Chang, Wei-Fan Hsu, Kuo-Chih Tseng, Chi-Yi Chen in Digestive Diseases and Sciences (2024)

  9. No Access

    Article

    Cross-sectional study of hepatitis B virus infection in female breast cancer patients in China for the first time diagnosed

    The correlation between breast cancer and hepatitis B virus (HBV) remains inconclusive. This study aims to explore the serological status of HBV infection and past infection in different age groups of female b...

    Zhao-xing Li, Jie Huang, Lei Hu, Zhi-yu Jiang in Clinical and Translational Oncology (2024)

  10. Article

    Open Access

    The mechanism and therapeutic potential of lncRNA MIR497HG/miR-16-5p axis in breast cancer

    Breast cancer has become a major public health problem in the current society, and its incidence rate ranks the first among Chinese female malignant tumors. This paper once again confirmed the efficacy of lncR...

    Quan Cheng, Dong-Yang Yu, Yong-Hong Zhou, Jian-Yuan Huang in BMC Women's Health (2024)

  11. No Access

    Article

    Dynamic change of metabolic dysfunction-associated steatotic liver disease in patients with hepatitis C virus infection after achieving sustained virologic response with direct-acting antivirals

    Information on the dynamics of metabolic dysfunction-associated steatotic liver disease (MASLD) among hepatitis C virus patients achieving sustained virologic response (SVR12) with direct-acting antivirals (DAAs)...

    Chen-Hua Liu, Yu-** Chang, Yu-Jen Fang, Pin-Nan Cheng in Journal of Gastroenterology (2024)

  12. No Access

    Article

    Validation of the constitution in Chinese medicine questionnaires with the newly developed blood-vacuity category: a rare Taiwanese case study

    The concept of body constitution (BC) is a core notion in traditional Chinese medicine, used in diagnosis, treatment, and prevention; however, there is little standardization in terms of definitions and measur...

    Ting-Yu Huang, Shi-Chen Ou, Wei-Te Huang, Yu-Chuan Lin in Advances in Traditional Medicine (2024)

  13. Article

    Open Access

    AgriGAN: unpaired image dehazing via a cycle-consistent generative adversarial network for the agricultural plant phenotype

    Artificially extracted agricultural phenotype information exhibits high subjectivity and low accuracy, while the utilization of image extraction information is susceptible to interference from haze. Furthermor...

    **-Ting Ding, Yong-Yu Peng, Min Huang, Sheng-Jun Zhou in Scientific Reports (2024)

  14. Article

    Open Access

    Spray pyrolysis-derived W-doped MoSe2/rGO paper-like microspheres: optimization of microstructure and mesostructure for enhanced lithium storage

    Two-dimensional MoSe2 is a promising candidate for lithium-ion battery anodes. However, its conductivity and lithium storage volumetric effect still need to be optimized. In this work, W-doped MoSe2/rGO paper-lik...

    Wei Wang, Jun-Yu Chen, Jie Ouyang, Hong Yin, Ao-Jie Li, Liang Chen in Rare Metals (2024)

  15. No Access

    Article

    Differential Effects of Increasing Vapor Pressure Deficit on Photosynthesis at Steady State and Fluctuating Light

    Increasing photosynthetic efficiency in fluctuating light is an important strategy to improve plant growth. In nature, fluctuating light often occurs concomitantly with the change in vapor pressure deficit (VP...

    Ning-Yu Liu, Qiu-Yan Yang, Ji-Hua Wang, Shi-Bao Zhang in Journal of Plant Growth Regulation (2024)

  16. No Access

    Article

    Microstructures and mechanical properties of laser-directed energy deposited CrCoNi medium-entropy alloy

    The distinctive intrinsic heat treatment (IHT) originating from cyclic reheating in the laser-directed energy deposition (LDED) has attracted growing attention in recent years. In this investigation, simulatio...

    Wen-Jie Zhao, Chang-Yu Liu, Peng-Cheng Che, Zhi-Liang Ning, Hong-Bo Fan in Rare Metals (2024)

  17. No Access

    Article

    Enhancing network intrusion detection by lifelong active online learning

    Machine learning has been widely used to build intrusion detection models in detecting unknown attack traffic. How to train a model properly in order to attain the desired intrusion detection is an important t...

    Po-Jen Chuang, Pang-Yu Huang in The Journal of Supercomputing (2024)

  18. Article

    Open Access

    Develo** an entrustable professional activity for providing health education and consultation in occupational therapy and examining its validity

    Entrustable Professional Activities (EPA)-based assessment is easily and intuitively used in evaluating the learning outcomes of competency-based medical education (CBME). This study aimed to develop an EPA fo...

    Chung-Pei Fu, Ching-Kai Huang, Yi-Chiun Yang, Wei-Sheng Liao in BMC Medical Education (2024)

  19. Article

    Open Access

    Association of smoking cessation patterns and untreated smoking with glaucoma, cataract, and macular degeneration: a population-based retrospective study

    This study aims to assess the association between nicotine replacement therapy (NRT), varenicline, and untreated smoking with the risk of develo** eye disorders. We employed a new-user design to investigate ...

    Yuan-Tsung Tseng, Sheng-Tang Huang, Chun-Hsiang Wang, Ling-Yu Wang in Scientific Reports (2024)

  20. Article

    Open Access

    Locally advanced breast cancer patients should be cautious about the immediate breast reconstruction after mastectomy: a pooling analysis of safety and efficacy

    The purpose of this study was to compare safety and efficacy outcomes between immediate breast reconstruction (IBR) and mastectomy alone in locally advanced breast cancer patients.

    Cheng-Yu Zeng, Yan-Yu Qiu, Jia-Yi Li, Jian-Hao Huang in World Journal of Surgical Oncology (2024)

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