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Article
The association between cardiac T2*BOLD and quantitative flow ratio (QFR) in the diagnosis of stenotic coronary arteries in patients with multi-vessel coronary artery disease
T2*BOLD is based on myocardial deoxyhemoglobin content to reflect the state of myocardial oxygenation. Quantitative flow ratio is a tool for assessing coronary blood flow based on invasive coronary angiography.
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Article
Open AccessMulticenter study on clinical outcomes and poor prognostic factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment
Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae. However, the ...
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Article
Plastome structure, phylogeny and evolution of plastid genes in Reevesia (Helicteroideae, Malvaceae)
Reevesia is an eastern Asian-eastern North American disjunction genus in the family Malvaceae s.l. and comprises approximately 25 species. The relationships within the genus are not well understood. Here, 15 plas...
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Article
Open AccessDistinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis
The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting gut microbiota as a promising avenue for modulating autoimmunity. However, the characterization of the gut v...
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Article
Salinity affects C/N ratio through differential responses of carbon and nitrogen metabolism in mangrove Avicennia marina leaves revealed by combined analysis of transcriptome and metabolome
Salt is a critical environmental factor that profoundly impacts plant growth and development. However, the investigation into how plants regulate carbon and nitrogen metabolism in response to different levels ...
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Article
Open AccessFirst detection of Tetraparvovirus ungulate 1 in diseased cattle (Chinese Simmental) from Hunan province, China
Tetraparvovirus is an emerging parvovirus infecting a variety of mammals and humans, and associated with human diseases including severe acute respiratory infection and acute encephalitis syndrome. In the pres...
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Article
Open AccessBilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
Gene therapy is a promising approach for hereditary deafness. We recently showed that unilateral AAV1-hOTOF gene therapy with dual adeno-associated virus (AAV) serotype 1 carrying human OTOF transgene is safe and...
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Article
Regulatory effect of Yinchenhao decoction on bile acid metabolism to improve the inflammatory microenvironment of hepatocellular carcinoma in mice
Hepatocellular carcinoma (HCC) is a malignant tumor with extremely high mortality. The tumor microenvironment is the “soil” of its occurrence and development, and the inflammatory microenvironment is an import...
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Article
Open AccessThe impact of comorbidities on prolonged mechanical ventilation in patients with chronic obstructive pulmonary disease
In patients with chronic obstructive pulmonary disease (COPD) and acute respiratory failure, approximately 10% of them are considered to be at high risk for prolonged mechanical ventilation (PMV, > 21 days). P...
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Article
Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway
Hypertensive cerebrovascular remodeling involves the enlargement of vascular smooth muscle cells (VSMCs), which activates volume-regulated Cl− channels (VRCCs). The leucine-rich repeat-containing family 8 A (LRRC...
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Article
IRE1α: from the function to the potential therapeutic target in atherosclerosis
Inositol requiring enzyme 1 (IRE1) is generally thought to control the most conserved pathway in the unfolded protein response (UPR). Two isoforms of IRE1, IRE1α and IRE1β, have been reported in mammals. IRE1α...
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Article
Open AccessAge at lung cancer diagnosis in females versus males who never smoke by race and ethnicity
We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke.
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Article
Open AccessUSP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy
Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhi...
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Article
Open AccessA pair of atypical NLR-encoding genes confers Asian soybean rust resistance in soybean
Asian soybean rust (ASR), caused by Phakopsora pachyrhizi, is a devastating disease that is present in all major soybean-producing regions. The limited availability of resistant germplasm has resulted in a scarci...
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Article
Open AccessIsolated flat band in artificially designed Lieb lattice based on macrocycle supramolecular crystal
Isolated flat bands are known to host various strongly correlated phases due to the enhanced Coulomb interactions when the flat bands are gapped from dispersive bands. One way to achieve an isolated flat band ...
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Article
Driving factors behind multiple populations
Star clusters were historically considered simple stellar populations, with all stars sharing the same age and initial chemical composition. However, the presence of chemical anomalies in globular clusters (GC...
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Article
Open AccessCorrelation of distribution characteristics and dynamic changes of gut microbiota with the efficacy of immunotherapy in EGFR-mutated non-small cell lung cancer
The effects of gut microbiota and metabolites on the responses to immune checkpoint inhibitors (ICIs) in advanced epidermal growth factor receptor (EGFR) wild-type non-small cell lung cancer (NSCLC) have been stu...
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Article
A multicenter propensity score analysis of significance of hepatic resection type for early-stage hepatocellular carcinoma
The impact of hepatic resection type on long-term oncological prognosis of patients with early-stage hepatocellular carcinoma (HCC) has not been systematically investigated. We sought to determine risk factors...
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Article
CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission
Both peripheral and central corticotropin-releasing factor (CRF) systems have been implicated in regulating pain sensation. However, compared with the peripheral, the mechanisms underlying central CRF system i...
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Article
Impact of Hepatic Pedicle Clam** on Long-Term Survival Following Hepatectomy for Hepatocellular Carcinoma: Stratified Analysis Based on Intraoperative Blood Transfusion Status
Hepatic pedicle clam** (HPC) is frequently utilized during hepatectomy to reduce intraoperative bleeding and diminish the need for intraoperative blood transfusion (IBT). The long-term prognostic implication...
