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Article
Open AccessHarnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subty**
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is still challenging due to the lack of a capturing surface with strong target-binding affinity and non-target-ce...
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Article
Open AccessPIKfyve, expressed by CD11c-positive cells, controls tumor immunity
Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) and other myeloid cells with anti...
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Article
More than just aligning the teeth: Clear aligners with multifunctional prowess
With the increasing demand for beauty and health, clear aligners (CAs) have been widely applied among patients with malocclusion. However, patients treated with CAs also face some potential complications, such...
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Article
Open AccessBilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
Gene therapy is a promising approach for hereditary deafness. We recently showed that unilateral AAV1-hOTOF gene therapy with dual adeno-associated virus (AAV) serotype 1 carrying human OTOF transgene is safe and...
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Article
Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway
To explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) cells.
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Article
Open AccessThe applications of flexible electronics in dental, oral, and craniofacial medicine
Dental, oral, and craniofacial diseases jeopardize health and reduce the quality of life. Accessing disease-related signals in advance is beneficial to prevent the occurrence or progression of those diseases. ...
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Article
Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice
The pathophysiology of autism spectrum disorders (ASDs) is causally linked to postsynaptic scaffolding proteins, as evidenced by numerous large-scale genomic studies [1, 2] and in vitro and in vivo neurobiologica...
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Article
Open AccessA pair of atypical NLR-encoding genes confers Asian soybean rust resistance in soybean
Asian soybean rust (ASR), caused by Phakopsora pachyrhizi, is a devastating disease that is present in all major soybean-producing regions. The limited availability of resistant germplasm has resulted in a scarci...
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Article
Open AccessAnalysis of endophytic bacterial diversity in seeds of different genotypes of cotton and the suppression of Verticillium wilt pathogen infection by a synthetic microbial community
In agricultural production, fungal diseases significantly impact the yield and quality of cotton (Gossypium spp.) with Verticillium wilt posing a particularly severe threat.
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Article
Modulated noble metal/2D MOF heterostructures for improved hydrogen storage of MgH2
The conjugation of external species with two-dimensional (2D) materials has broad application prospects. In this study, we have explored the potential of noble metal/2D MOF heterostructures in hydrogen storage...
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Article
Open AccessRevolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives
The deployment of imaging examinations has evolved into a robust approach for the diagnosis of lymph node metastasis (LNM). The advancement of technology, coupled with the introduction of innovative imaging dr...
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction
Novel CHCHD2 mutations causing C-terminal truncation and interrupted CHCHD2 protein stability in Parkinson's disease (PD) patients were previously found. However, there is limited understanding of the underlying ...
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Article
CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission
Both peripheral and central corticotropin-releasing factor (CRF) systems have been implicated in regulating pain sensation. However, compared with the peripheral, the mechanisms underlying central CRF system i...
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Article
Open AccessCurriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editi...
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Article
Convex decompositions of Q-stochastic tensors and Bell locality in a multipartite system
Generalizing the notions of the row and the column stochastic matrices, we introduce the multidimensional Q-stochastic tensors. We prove that every Q-stochastic tensor can be decomposed as a convex combination of...
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Article
Perinatal prevalence of birth defects in the Mainland of China, 2000–2021: a systematic review and meta-analysis
Although birth defects are of great concern globally, the latest national prevalence has not yet been quantified in China. We conducted a systematic review and meta-analysis to estimate the perinatal prevalenc...
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Article
Milestone progress of the HEPS booster commissioning
The high-energy photon source (HEPS) is the first fourth-generation synchrotron light source facility in China. The HEPS injector consists of a linear accelerator (Linac) and a full energy booster. The booster...
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Article
Effects of Brown Fishmeal on Growth Performance, Digestibility, and Lipid Metabolism of the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)
The aim of this study was to evaluate the effect of brown fishmeal in replacement of white fishmeal in the diet of Chinese soft-shelled turtles and to find the optimal amount of brown fishmeal to add. Five exp...
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Chapter and Conference Paper
Optimization Study of Conversion Timing for Secondary Development & Tertiary Recovery in the Ultra-High-Water-Cut Oilfield Based on Multi-factor Decision-Making
With the entry of oilfield into the middle and late stages of development, in order to maintain stable production and increase recoverable reserves, the technology of Secondary Development & Tertiary Recovery has...
