23 Result(s)

Article

Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer

Digital pathology allows computerized analysis of tumor ecosystem using whole slide images (WSIs). Here, we present single-cell morphological and topological profiling (sc-MTOP) to characterize tumor ecosystem...

Shen Zhao, De-Pin Chen, Tong Fu, **g-Cheng Yang, Ding Ma… in Nature Communications (2023)

Article

Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis

Peritoneal metastasis is the leading cause of death for gastrointestinal cancers. The native and therapy-induced ascites ecosystems are not fully understood. Here, we characterize single-cell transcriptomes of...

Xuan-Zhang Huang, Min-Jiao Pang, Jia-Yi Li, Han-Yu Chen… in Nature Communications (2023)

Article

Continuous exposure to isoprenaline reduced myotube size by delaying myoblast differentiation and fusion through the NFAT-MEF2C signaling pathway

We aimed to explore whether superfluous sympathetic activity affects myoblast differentiation, fusion, and myofiber types using a continuous single-dose isoprenaline exposure model in vitro and to further conf...

**g Yue, Wei Xu, Li **ang, Shao-juan Chen, **n-yuan Li, Qian Yang… in Scientific Reports (2023)

Article

A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis

The signaling mechanisms underlying adipose thermogenesis have not been fully elucidated. Particularly, the involvement of adipokines that are selectively expressed in brown adipose tissue (BAT) and beige adip...

Qingbo Chen, Lei Huang, Dongning Pan, Kai Hu, Rui Li… in Nature Communications (2022)

Article

The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS

The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) plays a critical role in antiviral immunity and autoimmunity. The activity and stability of cGAS are fine-tuned by post-translational modifications. Here...

Tian-Chen **ong, Ming-Cong Wei, Fang-Xu Li, Miao Shi, Hu Gan… in Nature Communications (2022)

Article

Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...

Si-Yang Liu, Hua Bao, Qun Wang, Wei-Min Mao, Yedan Chen… in Nature Communications (2021)

Article

Author Correction: Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

Yong-xi Song, **g-xu Sun, Jun-hua Zhao, Yu-chong Yang… in Nature Communications (2021)

Article

Effect of biodegradable chelators on induced phytoextraction of uranium- and cadmium- contaminated soil by Zebrina pendula Schnizl

This study investigated the effect of ethylenediamine-N,N′-disuccinic acid (EDDS), oxalic acid (OA), and citric acid (CA) on phytoextraction of U- and Cd-contaminated soil by Z. pendula. In this study, the biomas...

Li Chen, Dan Wang, Chan Long, Zheng-xu Cui in Scientific Reports (2019)

Article

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

Reversible post-translational modifications represent a mechanism to control tumor metabolism. Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and dema...

Yun-Qian Wang, Hao-Lian Wang, Jie Xu, Juan Tan, Lin-Na Fu… in Nature Communications (2018)

Article

Identification of long non-coding RNAs in the immature and mature rat anterior pituitary

Many long non-coding RNAs (lncRNAs) have been identified in several types of human pituitary adenomas and normal anterior pituitary, some of which are involved in the pathogenesis of pituitary adenomas. Howeve...

Dong-Xu Han, Xu-Lei Sun, Yao Fu, Chang-Jiang Wang, Jian-Bo Liu… in Scientific Reports (2017)

Article

Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this stu...

Yong-xi Song, **g-xu Sun, Jun-hua Zhao, Yu-chong Yang… in Nature Communications (2017)

Article

Netrin-1 promotes glioma growth by activating NF-κB via UNC5A

Gliomas, a common type of brain tumor, are characterized by aggressive infiltration, making it difficultly to cure by surgery. Netrin-1, an extracellular guidance cue critical for neuronal axon path-finding, h...

**g-Ying Chen, **ao-**ao He, Chi Ma, **n-Min Wu, **-Lin Wan… in Scientific Reports (2017)

Article

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

Browning of subcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are incompletely understood. Here we show that the transcription factor Hlx is selectively expresse...

Lei Huang, Dongning Pan, Qingbo Chen, Lihua J. Zhu, Jianhong Ou… in Nature Communications (2017)

Article

Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. How...

Hong-Yi Zheng, Ming-Xu Zhang, Min Chen, ** Jiang, Jia-Hao Song… in Scientific Reports (2017)

Article

Retraction Note: Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL

Scientific Reports 6: Article number: 19222; published online: 12 January 2016; updated: 13 May 2016. The authors of this Article have requested that it is retracted. In the western blotting analysis, the rabb...

**-Feng **ang, Wen-Quan Wang, Liang Liu, Hua-**ang Xu, Chun-Tao Wu… in Scientific Reports (2016)

Article

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

Necroptosis has been shown as an alternative form of cell death in many diseases, but the detailed mechanisms of the neuron loss after traumatic brain injury (TBI) in rodents remain unclear. To investigate whe...

Tao Liu, Dong-xu Zhao, Hua Cui, Lei Chen, Ying-hui Bao, Yong Wang… in Scientific Reports (2016)

Article

cGMP Signalling Mediates Water Sensation (Hydrosensation) and Hydrotaxis in Caenorhabditis elegans

Animals have developed the ability to sense the water content in their habitats, including hygrosensation (sensing humidity in the air) and hydrosensation (sensing the water content in other microenvironments)...

Wei Wang, Li-Wei Qin, Tai-Hong Wu, Chang-Li Ge, Ya-Qian Wu… in Scientific Reports (2016)

Article

The distinct clinical features and prognosis of the CD10⁺MUM1⁺ and CD10⁻Bcl6⁻MUM1⁻ diffuse large B-cell lymphoma

Using an immunohistochemistry (IHC) based method, diffuse large B-cell lymphoma (DLBCL) can be classified into germinal center B-cell (GCB) and non-GCB subtypes. However, the prognostic value of Hans algorithm...

Ting-Xun Lu, Yi Miao, Jia-Zhu Wu, Qi-**ng Gong, **-Hua Liang… in Scientific Reports (2016)

Article

Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL

Patients with pancreatic ductal adenocarcinoma (PDAC) and preoperative CA19-9 ≥ 1,000 U/mL that does not decrease postresection have the worst prognosis, but the mechanism is unclear. Here, we elucidated the r...

**-Feng **ang, Wen-Quan Wang, Liang Liu, Hua-**ang Xu, Chun-Tao Wu… in Scientific Reports (2016)

Article

Design and fabrication of far ultraviolet filters based on π-multilayer technology in high-k materials

Application of π-multilayer technology is extended to high extinction coefficient materials, which is introduced into metal-dielectric filter design. Metal materials often have high extinction coefficients in ...

**ao-Dong Wang, Bo Chen, Hai-Feng Wang, Fei He, **n Zheng… in Scientific Reports (2015)