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Article
Design parameter optimization method for a prestressed steel structure driven by multi-factor coupling
To achieve efficient structural design, it is crucial to reduce the cost of materials while ensuring structural safety. This study proposes an optimization method for design parameters (DPs) in a prestressed s...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Open AccessPrognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy
The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...
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Article
A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects
FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment both as a monotherapy or in combin...
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Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
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Article
Open AccessContrasting nidification behaviors facilitate diversification and colonization of the Music frogs under a changing paleoclimate
In order to cope with the complexity and variability of the terrestrial environment, amphibians have developed a wide range of reproductive and parental behaviors. Nest building occurs in some anuran species a...
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Article
Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke
Neuronal ferroptosis plays a key role in neurologic deficits post intracerebral hemorrhage (ICH). However, the endogenous regulation of rescuing ferroptotic neurons is largely unexplored. Here, we analyzed the...
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Article
Open Accesscirc_PPAPDC1A promotes Osimertinib resistance by sponging the miR-30a-3p/ IGF1R pathway in non-small cell lung cancer (NSCLC)
Recent evidence has demonstrated that abnormal expression and regulation of circular RNA (circRNAs) are involved in the occurrence and development of a variety of tumors. The aim of this study was to investiga...
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Article
Open AccessAnalysis of sterilizer allocation and related factors in dental health-care settings in Yunnan Province, China: a cross-sectional study
To investigate the status and related factors of sterilizers in dental health-care settings in Yunnan Province, with the aim of providing a theoretical basis for the health administrative department to formula...
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Article
Open AccessA prospective phase II clinical trial of total neoadjuvant therapy for locally advanced gastric cancer and gastroesophageal junction adenocarcinoma
To investigate the safety and efficacy of the neoadjuvant chemoradiotherapy (NCRT) followed by neoadjuvant consolidation chemotherapy (NCCT) and surgery for locally advanced gastric cancer (GC) or gastroesopha...
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Article
Association between alcohol consumption and sleep traits: observational and mendelian randomization studies in the UK biobank
Previous studies have shown that excessive alcohol consumption is associated with poor sleep. However, the health risks of light-to-moderate alcohol consumption in relation to sleep traits (e.g., insomnia, sno...
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Article
Open AccessPrognostic value of right atrial strains in arrhythmogenic right ventricular cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by progressive fibrofatty infiltration of atrial and ventricular myocardium resulting in adverse cardiac even...
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Article
Label-Aware Chinese Event Detection with Heterogeneous Graph Attention Network
Event detection (ED) seeks to recognize event triggers and classify them into the predefined event types. Chinese ED is formulated as a character-level task owing to the uncertain word boundaries. Prior method...
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Article
Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
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Article
Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is under investigation. In t...
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Article
Effect of solid solution treatment on microstructure and properties of extruded 7055 aluminum alloy
The effect of solid solution parameter and quenching cooling rate on the microstructure and properties of the 7055 aluminum alloy was studied by scanning electron microscopy (SEM), transmission electron micros...
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Article
Deep insight of unique phase transition behaviors and mechanism in Zr2Co-H isotope system with ultra-low equilibrium pressure
Efficient capture, safe storage and release of tritium from the international thermonuclear experimental reactor (ITER) reaction exhaust gas is a perplexing problem, and the development of an efficient tritium...
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Article
Titanium nitride nanorod array/carbon cloth as flexible integrated host for highly stable lithium–sulfur batteries
Lithium–sulfur (Li–S) batteries have been regarded as promising energy-storage systems, due to their high theoretical capacity and energy density. However, the carbonaceous sulfur hosts suffer from weak bindin...
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Article
Effectiveness of Zhenqi Buxue Oral Liquid Combined with Progesterone for Treatment of Oligomenorrhea and Hypomenorrhea with Qi-Blood and Kidney (Shen) Essence Deficiency: A Randomized Controlled Trial
To evaluate the effectiveness and safety of Zhenqi Buxue Oral Liquid (ZQ), progesterone capsules, and their combination in treating oligomenorrhea and hypomenorrhea with qi-blood and Kidney (Shen) essence defi...
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Article
Open AccessScalable and efficient solar-driven atmospheric water harvesting enabled by bidirectionally aligned and hierarchically structured nanocomposites
Extracting water from air is a promising route to address the global challenge of water scarcity. Sorption-based atmospheric water harvesting (SAWH) has the capability of capturing water from air anytime and a...
