1,199 Result(s)
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**g-Li Yue
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Article
Open AccessIncreased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...
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Open AccessMETTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer
Diabetic foot ulcer (DFU) is the most devastating complication of diabetes mellitus (DM) and plays a major role in disability and death in DM patients. NADH: ubiquinone oxidoreductase subunit B5 (NDUFB5) plays...
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Towards long-life 500 Wh kg−1 lithium metal pouch cells via compact ion-pair aggregate electrolytes
The development of practical lithium metal cells is plagued by their limited lifespan, primarily due to the poor interfacial stability of the electrolytes. Here we present a compact ion-pair aggregate (CIPA) e...
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Open AccessOTUB1 regulates ferroptosis to inhibit myoblast differentiation into myotubes by deubiquitinating P62
As the largest organ in the human body, skeletal muscle is essential for breathing support, movement initiation, and maintenance homeostasis. It has been shown that programmed cell death (PCD), which includes ...
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Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system
Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas systems are prokaryotic adaptive immune systems against invading phages and other mobile genetic elements. Notably, some phages, including...
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Operando measurement of lattice deformation profiles of synchrotron radiation monochromator
This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale ther...
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Correction to: Association Between a Failed Prominence Eruption and the Drainage of Mass from Another Prominence
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Comparative genome-wide analysis of circular RNAs in Brassica napus L.: target-site versus non-target-site resistance to herbicide stress
Circular RNAs (circRNAs), a class of non-coding RNA molecules, are recognized for their unique functions; however, their responses to herbicide stress in Brassica napus remain unclear. In this study, the role of ...
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Open AccessImage smoothing method based on global gradient sparsity and local relative gradient constraint optimization
Removing texture while preserving the main structure of an image is a challenging task. To address this, this paper propose an image smoothing method based on global gradient sparsity and local relative gradie...
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Distribution, risk evaluation, and source allocation of cesium and strontium in surface soil in a mining city
Radioactive nuclides cesium (Cs) and strontium (Sr) possess long half-lives, with 135Cs at approximately 2.3 million years and 87Sr at about 49 billion years. Their persistent accumulation can result in long-last...
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A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including Alzheimer’s disease (AD). We have recently conceptualize...
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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
Major depressive disorder, a prevalent and severe psychiatric condition, necessitates development of new and fast-acting antidepressants. Genetic suppression of astrocytic inwardly rectifying potassium channel...
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Toward a solid microneedle patch for rapid and enhanced local analgesic action
Analgesic creams find widespread application as adjuncts for localized anesthesia prior to surgical procedures. Nevertheless, the onset of analgesic action is protracted due to the skin barrier’s inherent char...
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A bifunctional nitrile additive for high-performance lithiumoxygen batteries
Li-O2 batteries with high energy density hold significant promise as next-generation energy storage systems. However, Li-O2 batteries have poor cycling performance at high current densities and large capacities, ...
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Open AccessA randomized, double-blind, placebo-controlled, phase IIa, clinical study on investigating the efficacy and safety of SPH3127 tablet in patients with essential hypertension
Around 70% of patients diagnosed with hypertension exhibit increased levels of renin. SPH3127, an inventive renin inhibitor, has shown favorable tolerability and sustained pharmacodynamic inhibitory impact on ...
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UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia **exin Decoction in Colorectal Cancer Mice
To clarify the potential mechanism of Banxia **exin Decoction (BXD) on colorectal cancer (CRC) from the perspective of metabolomics.
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Thermoelectric transport properties of p-type Bi2Se3–Sb2Se3–In2Se3 high entropy compounds
The introduction of entropy concept into thermoelectric materials recently has attracted broad interest. Herein, we showed the phase diagram of the ternary systems of Bi2Se3–Sb2Se3–In2Se3. Among the high entropy ...
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Self-powered and charge-transport-layer-free photodetectors based on chloride treated perovskites for weak light detection
Organic-inorganic halide perovskite materials have been widely used in photodetectors (PDs) for the solution processability and outstanding optoelectronic characteristics. However, conventional perovskite-base...
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Microfluidic synthesis of hollow CsPbBr3 perovskite nanocrystals through the nanoscale Kirkendall effect
All inorganic metal halide perovskite nanocrystals (NCs) have attracted much attention for their outstanding optoelectronic properties, which can be tuned by the composition, surface, size and morphology in na...
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Open AccessCRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...
