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Article
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65−/−) mice exhibit a...
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Article
Mechanical Behavior and Failure Mechanism of an As-Extruded Mg–11wt%Y Alloy at Elevated Temperature
Through carrying out the high-temperature tensile experiments on an as-extruded Mg–11wt%Y alloy at 350 °C, 400 °C, 450 °C, 500 °C and 550 °C, the mechanical behavior and fracture mechanisms at elevated tempera...
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Article
Improved seed yield and phosphorus accumulation in soybean are associated with the enhanced root exudates in south-west China
Shoot traits related to soybean yield improvement are well characterized, but little is known about changes in root traits and their contribution to yield improvements under different P levels.
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Article
Effect of multiple coulomb scattering on the beam tests of silicon pixel detectors
In the research and development of new silicon pixel detectors, a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification ...
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Article
Asymptotic analyses for trend-stationary pairs trading strategy in high-frequency trading
Conventional pairs trading strategies (PTS) exploit the mean-reverting nature of stock pairs with stationary value processes. This paper elevates PTS by integrating trend-stationary value processes, thereby en...
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Article
Open AccessSUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma
The protein annexin A6 (AnxA6) is involved in numerous membrane-related biological processes including cell migration and invasion by interacting with other proteins. The dysfunction of AnxA6, including protei...
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Article
COVID-19 vaccination affects short-term anti-coagulation levels in warfarin treatment
Vaccines against SARS-CoV-2 have been recommended across the world, yet no study has investigated whether COVID-19 vaccination influences short-term warfarin anti-coagulation levels. Patients on stable warfari...
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Article
Open AccessMutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death
Mutant KRAS (KRASMUT) is often exploited by cancers to shape tumor immunity, but the underlying mechanisms are not fully understood. Here we report that tumor-specific cytotoxic T lymphocytes (CTLs) from KRASMUT ...
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Article
NνDEx-100 conceptual design report
Observing nuclear neutrinoless double beta (0 \(\nu \beta \beta\) ν ...
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Article
Open AccessNovel beagle model of gastric local fibrotic target lesions for the evaluation and training of endoscopic techniques
Novel endoscopic techniques used in the treatment of gastric lesions with local submucosal fibrosis need preclinical evaluation and training due to safety limitations. Therefore, the purpose of our study was t...
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Article
Open AccessLppA is a novel plasminogen receptor of Mycoplasma bovis that contributes to adhesion by binding the host extracellular matrix and Annexin A2
Mycoplasma bovis is responsible for various inflammatory diseases in cattle. The prevention and control of M. bovis are complicated by the absence of effective vaccines and the emergence of multidrug-resistant st...
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Article
Open AccessPrediction model of no-response before the first transarterial chemoembolization for hepatocellular carcinoma: TACF score
Previous clinic models for patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) mainly focused on the overall survival, whereas a simple-to-use tool for predicting the ...
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Article
Adjuvant immune checkpoint inhibitors associated with higher recurrence-free survival in postoperative hepatocellular carcinoma (PREVENT): a prospective, multicentric cohort study
Adjuvant therapy may improve survival of patients with hepatocellular carcinoma (HCC) after curative resection. This study compared safety and efficacy outcomes between patients at high risk of recurrence who ...
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Article
Open AccessThe PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to overcome resistance1,2. The protein tyrosine phosphatases...
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Article
Open AccessMicrocosm study on fate and dynamics of mangrove tannins during leaf litter leaching
Mangrove tannins can participate in wetland biogeochemical cycling. However, their fate and dynamics during leaf litter leaching have yet to be elucidated in coastal aquatic environments.
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Article
Drought adaptation of Bauhinia faberi var. Microphylla seedlings with dual inoculation of arbuscular mycorrhizal fungi
Bauhinia faberi via. Microphylla (BFM) is an important tree species for vegetation restoration in the dry valley of southwestern China. However, there were few studies on the application of arbuscular mycorrhizal...
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Article
An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles
Influenza polymerase (FluPol) transcribes viral mRNA at the beginning of the viral life cycle and initiates genome replication after viral protein synthesis. However, it remains poorly understood how FluPol sw...
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Article
Open AccessLineage-specific amplification and epigenetic regulation of LTR-retrotransposons contribute to the structure, evolution, and function of Fabaceae species
Long terminal repeat (LTR)-retrotransposons (LTR-RTs) are ubiquitous and make up the majority of nearly all sequenced plant genomes, whereas their pivotal roles in genome evolution, gene expression regulation ...
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Article
Comprehensive Treatment Uncertainty Analysis and PTV Margin Estimation for Fiducial Tracking in Robotic Liver Stereotactic Body Radiation Therapy
This study aims to quantify the uncertainties of CyberKnife Synchrony fiducial tracking for liver stereotactic body radiation therapy (SBRT) cases, and evaluate the required planning target volume (PTV) margins.
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Article
Self-aware circular response-guided attention for robust siamese tracking
Siamese trackers recently have achieved remarkable advancements in accuracy, yet the further improvement is subject to semantic interferences. An potential reason may be the lack of prior information in visual...
