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Article
Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women
In East Asia, the incidence of breast cancer has been increasing rapidly, particularly among premenopausal women. An elevated ratio of estrogen-DNA adducts was linked to a higher risk of breast cancer. The pre...
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Article
Open AccessAuthor Correction: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
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Article
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived natural compounds are considered i...
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Article
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase
Thymic egress is a crucial process for thymocyte maturation, strictly regulated by sphingosine-1-phosphate lyase (S1PL). Recently, cystathionine γ-lyase (CSE), one of the enzymes producing hydrogen sulfide (H2S),...
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Article
Open AccessModeling the mid-piacenzian warm climate using the water isotope-enabled Community Earth System Model (iCESM1.2-ITPCAS)
The mid-Piacenzian Warm Period (MPWP, ~ 3.264–3.025 Ma) is the most recent example of a persistently warmer climate in equilibrium with atmospheric CO2 concentrations similar to today. Towards studying patterns a...
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Article
Correction: Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
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Article
Lightweight, Strong and High Heat-Resistant Poly(lactide acid) Foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent
Poly(lactide acid) (PLA) foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams, such as polystyrene (PS) foams. Nevertheless, PLA foam typically suffers from low hea...
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Article
Open AccessReal-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan
Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is commit...
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Article
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer
In addition to the classical resistance mechanisms, receptor tyrosine-protein kinase AXL is a main mechanism of resistance to third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-T...
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Article
Open AccessAssociation between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer
Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...
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Article
Genome-wide association study and genomic selection of spike-related traits in bread wheat
Identification of 337 stable MTAs for wheat spike-related traits improved model accuracy, and favorable alleles of MTA259 and MTA64 increased grain weight and yield per plant.
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Article
Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
To evaluate the diagnostic performance of contrast-enhanced (CE) ultrasound using Sonazoid (SNZ–CEUS) by comparing with contrast-enhanced computed tomography (CE–CT) and contrast-enhanced magnetic resonance im...
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Article
Open AccessCircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1α-mediated glycometabolism alteration
Epidermal growth factor receptor (EGFR)-targeted therapy is an important treatment for RAS wild-type metastatic colorectal cancer (mCRC), but the resistance mechanism remains unclear. Here, the differential ex...
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Open AccessAuthor Correction: Multiple factors and features dictate the selective production of ct-siRNA in Arabidopsis
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Article
Two New Anti-SARS-CoV-2 Naphthoquinones from Cigar-Tobacco-Derived Endophytic Fusarium oxysporum
In this study, two new naphthoquinones, 6-isopropyl-7-methoxy-2-(2-oxopropyl)naphthalene-1,4-dione (1) and 7-hydroxy-6-isopropyl-2-(2-oxopropyl)naphthalene-1,4-dione (2), together with five known new naphthoquino...
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Article
Two New Antibacterial Isoindolin-1-Ones from Sun-Cured Tobacco and Their Potential Application in Antiseptic Cigarette Tip** Paper
Two new isoindolin-1-ones (1 and 2), were isolated from the stems of Nicotiana tabacum (a cultivar of sun-cured tobacco with high resistance to black shank diseases, which originated from Huize local sun-cured to...
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Article
Open AccessArginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine
Bacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies have focused on gram-negative bacterial outer membrane vesicles (OMVs) as a novel cancer immunotherapy str...
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Article
Comprehensive pan-cancer analysis reveals prognostic implications of TMEM92 in the tumor immune microenvironment
Transmembrane protein 92 (TMEM92) has been implicated in the facilitation of tumor progression. Nevertheless, comprehensive analyses concerning the prognostic significance of TMEM92, as well as its role in imm...
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Article
Open AccessMultiple factors and features dictate the selective production of ct-siRNA in Arabidopsis
Coding transcript-derived siRNAs (ct-siRNAs) produced from specific endogenous loci can suppress the translation of their source genes to balance plant growth and stress response. In this study, we generated Arab...
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Article
Performance evaluation of underground pipelines subjected to landslide thrust with fiber optic strain sensing nerves
High-accuracy deformation monitoring is crucial for investigating landslide–pipeline interaction problems, in which the fiber optic nerve system (FONS) holds enormous potential. This paper presents a theoretic...
