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Article
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer’s Disease
Neuroinflammation and endothelial cell apoptosis are prominent features of blood–brain barrier (BBB) disruption, which have been described in Alzheimer’s disease (AD) and can predict cognitive decline. Recent ...
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Article
Open AccessGerm granule compartments coordinate specialized small RNA production
Germ granules are biomolecular condensates present in most animal germ cells. One function of germ granules is to help maintain germ cell totipotency by organizing mRNA regulatory machinery, including small RN...
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Article
Open AccessNicotinamide riboside restores nicotinamide adenine dinucleotide levels and alleviates brain injury by inhibiting oxidative stress and neuroinflammation in a mouse model of intracerebral hemorrhage
Hemorrhagic stroke is a global health problem owing to its high morbidity and mortality rates. Nicotinamide riboside is an important precursor of nicotinamide adenine dinucleotide characterized by a high bioav...
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Article
Two Monte Carlo-based simulators for imaging-system modeling and projection simulation of flat-panel X-ray source
The advantages of a flat-panel X-ray source (FPXS) make it a promising candidate for imaging applications. Accurate imaging-system modeling and projection simulation are critical for analyzing imaging performa...
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Article
Asymmetric catalytic synthesis of chiral covalent organic framework composite (S)-DTP-COF@SiO2 for HPLC enantioseparations by normal-phase and reversed-phase chromatographic modes
A novel CCOF core–shell composite material (S)-DTP-COF@SiO2 was prepared via asymmetric catalytic and in situ growth strategy. The prepared (S)-DTP-COF@SiO2 was utilized as separation medium for HPLC enantiosepar...
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Article
Transparent PVDF-based electrolyte enabled by lipophilic lithium magnesium silicate for solid-state lithium batteries
Solid-state batteries with solid polymer electrolytes are considered the most promising due to their high energy density and safety advantages. However, their development is hindered by the limitations of poly...
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Article
Open AccessRemote ischemic conditioning prevents ischemic cerebrovascular events in children with moyamoya disease: a randomized controlled trial
Moyamoya disease (MMD) is a significant cause of childhood stroke and transient ischemic attacks (TIAs). This study aimed to assess the safety and efficacy of remote ischemic conditioning (RIC) in children wit...
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Article
Open AccessCold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...
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Article
Open AccessModified craniotomy procedures and virtual reality technology for accurate localization of the frontal branch of MMA in revascularization surgery
The frontal branch of middle meningeal artery (MMA) can easily be damaged during revascularization surgery. To precise locate it and minimize its injury, we propose a set of modified craniotomy procedures comb...
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Article
Open AccessCirc_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC
The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health an...
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Article
Open AccessContinental and oceanic AAM contributions to Chandler Wobble with the amplitude attenuation from 2012 to 2022
We reconstructed the Chandler Wobble (CW) from 1962 to 2022 by combining the Eigen-oscillator excited by geophysical fluids of atmospheric and oceanic angular momentums (AAM and OAM). The mass and motion terms...
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Article
Open AccessOral pimonidazole unveils clinicopathologic and epigenetic features of hypoxic tumour aggressiveness in localized prostate cancer
Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the cl...
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Article
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice
Urolithin A (UroA), a dietary phytochemical, is produced by gut bacteria from fruits rich in natural polyphenols ellagitannins (ETs). The efficiency of ETs metabolism to UroA in humans depends on gut microbiot...
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Article
Open AccessPredictors of futile recanalization after endovascular treatment of acute ischemic stroke
Endovascular therapy (EVT) is the most successful treatment for patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) in the anterior circulation. However, futile recanalization (FR) se...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Open AccessThe effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system
Low immunity and sleep disorders are prevalent suboptimal health conditions in contemporary populations, which render them susceptible to the infiltration of pathogenic factors. LJC, which has a long history i...
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Article
Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study
To describe the treatment patterns and survival status of advanced gastric cancer (AGC) in China in the past two decades, and objectively evaluate the impact of standardized Chinese medicine (CM) treatment on ...
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Article
Robotic gastrectomy was reliable option for overweight patients with gastric cancer: a propensity score matching study
The role of minimally invasive surgery using robotics versus laparoscopy in resectable gastric cancer patients with a high body mass index (BMI) remains controversial.
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Article
Open AccessHBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...
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Article
Pyroptosis is involved in the immune microenvironment regulation of unexplained recurrent miscarriage
Unexplained recurrent miscarriage (URM) is a common pregnancy complication with few effective therapies. Moreover, little is known regarding the role of pyroptosis in the regulation of the URM immune microenvi...
