139 Result(s)
within
**g-Han Li
Life Sciences
-
Article
Open AccessRegulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth
Development of the cerebellum requires precise regulation of granule neuron progenitor (GNP) proliferation. Although it is known that primary cilia are necessary to support GNP proliferation, the exact molecul...
-
Article
Open AccessDeficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease caused by hepatic steatosis. Adenosine deaminases acting on RNA (ADARs) catalyze adenosine to inosine RNA editing. However, the functional role of...
-
Article
A functional study reveals CsNAC086 regulated the biosynthesis of flavonols in Camellia sinensis
CsNAC086 was found to promote the expression of CsFLS, thus promoting the accumulation of flavonols in Camellia sinensis.
-
Article
Preventive and Therapeutic Potential of Streptococcus cristatus CA119 in Experimental Periodontitis in Rats
Periodontitis is an inflammatory condition of the oral cavity caused by a mixed infection of various bacteria, which not only severely affects the alveolar bone and connective tissues but also displays potenti...
-
Chapter
Phylogenetics and Phylogenomics for Inferring Relationships of Bacteria and Archaea Phyla
Phylogenetics and phylogenomics are two related fields that deal with the study of the evolutionary relationships between different organisms. In the context of bacteria and archaea phyla, these fields are use...
-
Chapter
Technologies Promoting Genome-Based Taxonomy
Whole-genome sequencing (WGS) has proven to be a reliable method. Additionally, it is a commonly used approach in research and surveillance investigations. With the goal of achieving a whole or nearly complete...
-
Article
Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na+/H+ antiporter
Salinity is one of the most severe abiotic stresses that adversely affect plant growth and agricultural productivity. The plant Na+/H+ antiporter Salt Overly Sensitive 1 (SOS1) located in the plasma membrane extr...
-
Article
Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway
We investigated the effects of lifelong aerobic exercise and 8 months of detraining after 10 months of aerobic training on circulation, skeletal muscle oxidative stress, and inflammation in aging rats. Sprague...
-
Article
Open AccessDevelopment and evaluation of the utility of GenoBaits Peanut 40K for a peanut MAGIC population
Population and genotype data are essential for genetic map**. The multi-parent advanced generation intercross (MAGIC) population is a permanent map** population used for precisely map** quantitative trai...
-
Article
Open AccessPotential selection for lipid kinase activity and spermatogenesis in Henan native pig breeds and growth sha** by introgression of European genes
China has one third of the worldwide indigenous pig breeds. The Henan province is one of the earliest pig domestication centers of China (about 8000 years ago). However, the precise genetic characteristics of ...
-
Article
Open AccessMetabolite profiles and antibacterial and antioxidant activities of leaf extracts of five Lonicera species: a comparative study
Lonicera japonica Flos is widely used as a medicinal plant in China owing to its various pharmacological activities. However, little is known about the metabolic profile and antibacterial properties of the leaves...
-
Article
Open AccessIGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer ...
-
Article
Open AccessL-DOPA induces iron accumulation in roots of Ipomoea aquatica and Arabidopsis thaliana in a pH-dependent manner
Iron deficiency is the leading cause of anemia worldwide, particularly in countries with predominant plant-based diets. Plants constitute the main source of dietary iron. Increasing their iron concentration co...
-
Article
Genome-wide association study reveals the genetic variation and candidate gene for grain calcium content in bread wheat
This study provides important information on the genetic basis of GCaC in wheat, thus contributing to breeding efforts to improve the nutrient quality of wheat.
-
Article
Open AccessPRDX1 negatively regulates bleomycin-induced pulmonary fibrosis via inhibiting the epithelial-mesenchymal transition and lung fibroblast proliferation in vitro and in vivo
Pulmonary fibrosis is a major category of end-stage changes in lung diseases, characterized by lung epithelial cell damage, proliferation of fibroblasts, and accumulation of extracellular matrix. Peroxiredoxin...
-
Article
Open AccessOAF is a DAF-like gene that controls ovule development in plants
We previously found that the RING-type E3 ligase DEFECTIVE IN ANTHER DEHISCENCE1- (DAD1-) Activating Factor (DAF) controls anther dehiscence by activating the jasmonate biosynthetic pathway in Arabidopsis. Here, ...
-
Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
-
Article
m6A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice
Different organs undergo distinct transcriptional, epigenetic and physiological alterations that guarantee their functional maturation after birth. However, the roles of epitranscriptomic machineries in these ...
-
Article
Open AccessHyperactive nanobacteria with host-dependent traits pervade Omnitrophota
Candidate bacterial phylum Omnitrophota has not been isolated and is poorly understood. We analysed 72 newly sequenced and 349 existing Omnitrophota genomes representing 6 classes and 276 species, along with E...
-
Article
Genome-wide signatures of the geographic expansion and breeding of soybean
Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We anal...
