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1,399 Result(s)
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Article
Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant neuronal excitability, synaptic impairment, and progressive cog...
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Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan
Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.
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Boosting ammonia production in electrocatalytic NOx reduction on a robust Fe/FeMoO4 catalyst
Electrocatalytic reduction of nitrate \(({\rm{N}}{{\rm{O}}_3}^ - )\) ( ...
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Article
Prescribed-time stabilization and optimization of CPS-based microgrids with event-triggered interactions
This paper investigates the problems of prescribed-time stabilization and optimization for microgrids with event-triggered interactions employing the cyber-physical system (CPS) framework. The main objective i...
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A robust strategy for realizing highly-efficient passive alignment of fiber ribbons to integrated polymer waveguides
The connection between ribbon fibers and optical waveguides is an ideal method for achieving precise coupling with other standard devices and is a key technology for the practical application of various integr...
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Open AccessAcoustic spin-controlled orbital rotations in double spiral acoustic beams
Similar to optical spin-orbit interactions (SOIs), acoustic SOIs are anticipated to offer fresh perspectives and capabilities for acoustic manipulation beyond conventional scalar degrees of freedom. However, t...
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Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy through activation of mTOR signalling
Reperfusion injury, which is distinct from ischaemic injury, occurs when blood flow is restored in previously ischaemic brain tissue, further compromising neurons and other cells and worsening the injury. Ther...
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Open AccessT cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer’s disease, we fou...
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A non-invasive artificial intelligence model for identifying axillary pathological complete response to neoadjuvant chemotherapy in breast cancer: a secondary analysis to multicenter clinical trial
This study aims to develop a stacking model for accurately predicting axillary lymph node (ALN) response to neoadjuvant chemotherapy (NAC) using longitudinal MRI in breast cancer.
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Article
Metal-slag separation strengthening through in situ slagging during CuW composite preparation by metallothermic reduction
CuW is widely used in high-voltage electrical switch contacts, rocket nozzle throat linings, electronic packaging materials and other major high-end technologies. CuW is typically fabricated using infiltration...
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Article
Petrogenesis of late Cretaceous high Ba–Sr granodiorites, SE Lhasa block, China: implications for the reworking of juvenile crust and continental growth
The high Ba–Sr rocks can provide significant clues about the evolution of the continent lithosphere, but their petrogenesis remains controversial. Identifying the Late Cretaceous high Ba–Sr granodiorites in th...
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Open AccessPrognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy
The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...
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Application of ambient noise tomography to coastal granite islands: A case study of Wuzhizhou Island in Hainan, China
Islands are valuable land resources in the ocean, and their detailed subsurface seismic velocity structures are highly important for underground space utilization, engineering construction, and geological disa...
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Open AccessStructural variant landscapes reveal convergent signatures of evolution in sheep and goats
Sheep and goats have undergone domestication and improvement to produce similar phenotypes, which have been greatly impacted by structural variants (SVs). Here, we report a high-quality chromosome-level refere...
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Numerical simulation of melt flow and temperature field during DC casting 2024 aluminium alloy under different casting conditions
Casting speed, casting temperature and secondary cooling water flow rate are the main process parameters affecting the DC casting process. These parameters significantly influence the flow and temperature fiel...
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Article
Correction to: Semi-automatic proximal humeral trabecular bone density assessment tool: technique application and clinical validation
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Article
Semi-automatic proximal humeral trabecular bone density assessment tool: technique application and clinical validation
This study aimed to apply a newly developed semi-automatic phantom-less QCT (PL-QCT) to measure proximal humerus trabecular bone density based on chest CT and verify its accuracy and precision.
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Article
Open AccessReal-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan
Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is commit...
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High-grade transformation of head and neck adenoid cystic carcinoma demonstrates distinctive clinicopathological features and an unfavorable prognosis: a matched case-control study of the largest series in China
Amidst the rarity of High-grade transformation (HGT) in adenoid cystic carcinoma (ACC), this study offers unprecedented insights into its aggressive nature and clinical implications.