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    Article

    α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity

    Emerging evidence demonstrates the vital role of synaptic transmission and structural remodeling in major depressive disorder. Activation of melanocortin receptors facilitates stress-induced emotional behavior...

    Qiao Deng, Shao-qi Zhang, **-fen Yang, Wan-ting Dong in Acta Pharmacologica Sinica (2023)

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    Article

    Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis

    Respiratory syncytial virus (RSV) is leading cause of respiratory tract infections in early childhood. Gut microbiota is closely related with the pulmonary antiviral immunity. Recent evidence shows that gut dy...

    Jian-jian Ji, Qin-mei Sun, Deng-yun Nie, Qian Wang, Han Zhang in Acta Pharmacologica Sinica (2021)

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    Article

    Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity

    Terpene lactones are a class of bioactive constituents of standardized preparations of Ginkgo biloba leaf extract, extensively used as add-on therapies in patients with ischemic cardiovascular and cerebrovascular...

    **n-wei Liu, Jun-ling Yang, Wei Niu, Wei-wei Jia in Acta Pharmacologica Sinica (2018)

  4. Article

    Adrenomedullin up-regulates osteopontin and attenuates vascular calcification via the cAMP/PKA signaling pathway

    To determine whether adrenomedullin (ADM) attenuates vascular calcification (VC) by inducing osteopontin (OPN) expression.

    Yan Cai, Xu Teng, Chun-shui Pan, **ao-hui Duan, Chao-shu Tang in Acta Pharmacologica Sinica (2010)

  5. Article

    Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats

    To determine the cardioprotective action of ghrelin and des-octanoyl ghrelin in rats with isoproterenol-induced myocardial injury.

    Lian Li, Li-ke Zhang, Yong-zheng Pang, Chun-shui Pan in Acta Pharmacologica Sinica (2006)

  6. Article

    Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3 plus nicotine in rats

    To investigate the role of the endogenous cystathionine γ-synthase (CSE)/ hydrogen sulfide (H2S) pathway in vascular calcification in vivo.

    Sheng-ying Wu, Chun-shui Pan, Bin Geng, **g Zhao, Fang Yu in Acta Pharmacologica Sinica (2006)