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Article
Benefits and Risks of Antihyperlipidemic Medication in Adults with Different Low-Density Lipoprotein Cholesterol Based on the Number Needed to Treat
The objective of this investigation is to examine the benefits and potential risks of these drugs in individuals by varying baseline low-density lipoprotein cholesterol (LDL-C) values, utilizing the concept of...
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Article
Open AccessThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia
In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly under...
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Chapter and Conference Paper
Application and Discussion of Diving-Wave Land Full-Waveform Inversion in Complex Mountainous Areas of Western China
The application of full-waveform inversion (FWI) to land seismic data remains challenging. Near-surface velocity model building exhibits specific difficulty, largely associated with low signal-to-noise ratio, ...
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Article
Open AccessAssociations of Wnt5a expression with liver injury in chronic hepatitis B virus infection
Aberrant Wnt5a expression contributes to immunity, inflammation and tissue damage. However, it remains unknown whether Wnt5a is associated with liver injury in chronic hepatitis B virus (HBV) infection. We aim...
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Article
Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study
Current guidelines discourage the use of direct-acting antiviral (DAA) containing protease-inhibitor (PI) in advanced HCV cirrhosis. We aimed to compare the real-world tolerability of PI vs. non-PI DAA regimen...
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Article
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity
Emerging evidence demonstrates the vital role of synaptic transmission and structural remodeling in major depressive disorder. Activation of melanocortin receptors facilitates stress-induced emotional behavior...
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Article
Open AccessEstablishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively modifies proteoglycans (PGs) of ...
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Chapter and Conference Paper
A Preprocessing Method of Seismic Wavelet for Land Full Waveform Inversion
The uncertainty and inconsistency of wavelet is an important obstacle to the promotion of land full waveform inversion. Based on the basic principle of full waveform inversion, a target matching method is prop...
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Article
Identification of novel inhibitors of S-adenosyl-L-homocysteine hydrolase via structure-based virtual screening and molecular dynamics simulations
S-adenosyl-L-homocysteine hydrolase (SAHase) is an important regulator in the methylation reactions in many organisms and thus is crucial for numerous cellular functions. In recent years, SAHase has become one of...
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Article
Chemical Constituents from Goniothalamus cheliensis with Nematicidal Activity Against Meloidogyne incognita
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Article
Intermedin1–53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis
Intermedin (IMD), a paracrine/autocrine peptide, protects against cardiac fibrosis. However, the underlying mechanism remains poorly understood. Previous study reports that activation of nucleotide-binding oli...
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Article
Open AccessMetabolic tuning of a stable microbial community in the surface oligotrophic Indian Ocean revealed by integrated meta-omics
Understanding the mechanisms, structuring microbial communities in oligotrophic ocean surface waters remains a major ecological endeavor. Functional redundancy and metabolic tuning are two mechanisms that have...
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Article
Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis
Respiratory syncytial virus (RSV) is leading cause of respiratory tract infections in early childhood. Gut microbiota is closely related with the pulmonary antiviral immunity. Recent evidence shows that gut dy...
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Article
Open AccessIntermedin1-53 attenuates atherosclerotic plaque vulnerability by inhibiting CHOP-mediated apoptosis and inflammasome in macrophages
Atherosclerotic plaque vulnerability and rupture increase the risk of acute coronary syndromes. Advanced lesion macrophage apoptosis plays important role in the rupture of atherosclerotic plaque, and endoplasm...
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Article
Unbalanced classification method using least squares support vector machine with sparse strategy for steel surface defects with label noise
Least squares support vector machine (LS-SVM) plays an important role in steel surface defects classification because of its high speed. However, the defect samples obtained from the real production line may b...
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Article
Study on the body surface temperature variation patterns of the meridian acupoints related to the physiological status of the uterus
By observing the body surface temperature changes of different meridian acupoints located at the same or adjacent spinal segments of the uterus during the whole storing and releasing process of the uterus unde...
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Article
Fungal diversity notes 1277–1386: taxonomic and phylogenetic contributions to fungal taxa
This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy, based on materials collected from many countries which were examined and described using the methods of morphology, ana...
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Article
Open AccessArginine is neuroprotective through suppressing HIF-1α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury
Neuroinflammation is a secondary response following ischemia stroke. Arginine is a non-essential amino acid that has been shown to inhibit acute inflammatory reaction. In this study we show that arginine treat...
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Article
A Riemannian Optimization Approach for Solving the Generalized Eigenvalue Problem for Nonsquare Matrix Pencils
In this paper, based on the Riemannian optimization approach we propose a Riemannian nonlinear conjugate gradient method with nonmonotone line search technique for solving the l parameterized original problem on ...
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Article
Open AccessA rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named “2019 novel coronavirus (2019-nCoV)” by the World Health Organization (WHO) on 12 January 2020. For it is a ...
