121 Result(s)
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Article
Sequence and analysis of rice chromosome 4
Rice is the principal food for over half of the population of the world. With its genome size of 430 megabase pairs (Mb), the cultivated rice species Oryza sativa is a model plant for genome research1. Here we re...
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Fermi surface dichotomy of the superconducting gap and pseudogap in underdoped pnictides
High-temperature superconductivity in iron-arsenic materials (pnictides) near an antiferromagnetic phase raises the possibility of spin-fluctuation-mediated pairing. However, the interplay between antiferromag...
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Open AccessER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis
Auxin is a key coordinative signal required for many aspects of plant development and its levels are controlled by auxin metabolism and intercellular auxin transport. Here we find that a member of PIN auxin tr...
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Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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NANOG-dependent function of TET1 and TET2 in establishment of pluripotency
The authors show that the pluripotency factor NANOG interacts with TET1 and TET2 methylcytosine hydroxylases, and that the hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine enhances the efficiency o...
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Open AccessDiscovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl-tRNA synthetase (LeuRS) plays an...
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Open AccessManageable N-doped Graphene for High Performance Oxygen Reduction Reaction
Catalysts for oxygen reduction reaction (ORR) are at the heart of key green-energy fuel cell technology. N-doped graphene is a potential metal-free electrode with much better electrocatalytic activity, long-te...
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Open AccessA novel semiconductor compatible path for nano-graphene synthesis using CBr4 precursor and Ga catalyst
We propose a novel semiconductor compatible path for nano-graphene synthesis using precursors containing C-Br bonding and liquid catalyst. The unique combination of CBr4 as precursor and Ga as catalyst leads to e...
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Open AccessExtraordinary Second Harmonic Generation in Tungsten Disulfide Monolayers
We investigate Second Harmonic Generation (SHG) in monolayer WS2 both deposited on a SiO2/Si substrate or suspended using transmission electron microscopy grids. We find unusually large second order nonlinear sus...
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Article
Inflammatory caspases are innate immune receptors for intracellular LPS
The murine caspase-11 non-canonical inflammasome responds to various bacterial infections. Caspase-11 activation-induced pyroptosis, in response to cytoplasmic lipopolysaccharide (LPS), is critical for endotox...
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Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
A working model for histone H3-induced dynamic regulation of the de novo DNA methyltransferase.
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Open AccessPhysicochemical Evolution and Molecular Adaptation of the Cetacean Osmoregulation-related Gene UT-A2 and Implications for Functional Studies
Cetaceans have an enigmatic evolutionary history of re-invading aquatic habitats. One of their essential adaptabilities that has enabled this process is their homeostatic strategy adjustment. Here, we investig...
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Open AccessDesigned hybrid nanostructure with catalytic effect: beyond the theoretical capacity of SnO2 anode material for lithium ion batteries
Transition metal cobalt (Co) nanoparticle was designed as catalyst to promote the conversion reaction of Sn to SnO2 during the delithiation process which is deemed as an irreversible reaction. The designed nanoco...
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Open AccessFluorescent water-soluble organic aerosols in the High Arctic atmosphere
Organic aerosols are ubiquitous in the earth’s atmosphere. They have been extensively studied in urban, rural and marine environments. However, little is known about the fluorescence properties of water-solubl...
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Open AccessFunctional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases
The His-x-Asp (HxD) motif is one of the most conserved structural components of the catalytic core of protein kinases; however, the functional role of the conserved histidine is unclear. Here we report that re...
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Open AccessAmniotic fluid stem cells provide considerable advantages in epidermal regeneration: B7H4 creates a moderate inflammation microenvironment to promote wound repair
The current treatments for severe skin injury all involve skin grafting. However, there is a worldwide shortage of donor skin tissue. In this study, we examined the advantages of using human amniotic fluid ste...
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Open AccessStructure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis
Nosiheptide is a parent compound of thiopeptide family that exhibit potent activities against various bacterial pathogens. Its C-terminal amide formation is catalyzed by NosA, which is an unusual strategy for ...
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Open AccessThe transcriptional landscape of age in human peripheral blood
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression met...
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Open AccessProtective immune barrier against hepatitis B is needed in individuals born before infant HBV vaccination program in China
The hepatitis B prevalence rate in adults is still at a high to intermediate level in China. Our purpose was to explore the incidence rate and protective immune barrier against hepatitis B in adults in China. ...
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Open AccessDiscovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion
Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is limited by the inability to expa...
