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Article
Open AccessBenmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial
Immunochemotherapy is the first-line standard for extensive-stage small-cell lung cancer (ES-SCLC). Combining the regimen with anti-angiogenesis may improve efficacy. ETER701 was a multicenter, double-blind, r...
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Article
Synthesis of Nano-sheet SAPO-34 Zeolites Via Aminothermal Method and Its Methanol to Olefins (MTO) Performance
In this study, nano-sheet SAPO-34 molecular sieves were synthesized using an aminothermal method. Triethylamine (TEA) was used as the major solvent and template, along with varying amounts of tetraethylammoniu...
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Article
Digital twins of nonlinear dynamical systems: a perspective
Digital twins have attracted a great deal of recent attention from a wide range of fields. A basic requirement for digital twins of nonlinear dynamical systems is the ability to generate the system evolution a...
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Article
Open AccessAcoustic spin-controlled orbital rotations in double spiral acoustic beams
Similar to optical spin-orbit interactions (SOIs), acoustic SOIs are anticipated to offer fresh perspectives and capabilities for acoustic manipulation beyond conventional scalar degrees of freedom. However, t...
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Article
Open AccessGeneration and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders
Neurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating childhood psychiatric conditions. Genetic factors are recognized as playing ...
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Article
Open AccessHER2-targeting antibody drug conjugate FS-1502 in HER2-expressing metastatic breast cancer: a phase 1a/1b trial
Currently approved HER2-targeting antibody-drug conjugates (ADCs) for HER2-positive breast cancer (BC) are associated with safety concerns. In this multicenter, single-arm, dose-escalation (phase 1a) and dose-...
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Article
Open AccessReservoir-computing based associative memory and itinerancy for complex dynamical attractors
Traditional neural network models of associative memories were used to store and retrieve static patterns. We develop reservoir-computing based memories for complex dynamical attractors, under two common recal...
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Article
A digital twin-enhanced collaborative maintenance paradigm for aero-engine fleet
Maintenance of aero-engine fleets is crucial for the efficiency, safety, and reliability of the aviation industry. With the increasing demand for air transportation, maintaining high-performing aero-engines ha...
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Article
Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway
To explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) cells.
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Article
Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial
The vascular endothelial growth factor pathway plays a key role in the pathogenesis of gastric cancer. In the multicenter, double-blind phase 3 FRUTIGA trial, 703 patients with advanced gastric or gastroesopha...
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Article
Open AccessCamrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC: results from an open-label multicenter phase 2 basket study
The combination of immune checkpoint inhibitors and antiangiogenic agents has been effective in treating multiple cancers. This was further explored in an open-label, multicenter phase 2 basket study (NCT04346...
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Article
Open AccessEfficacy and safety of surufatinib plus toripalimab, a chemotherapy-free regimen, in patients with advanced gastric/gastroesophageal junction adenocarcinoma, esophageal squamous cell carcinoma, or biliary tract cancer
The programmed death 1 inhibitor toripalimab plus the angio-immuno kinase inhibitor surufatinib showed a tolerable safety profile and preliminary efficacy in patients with advanced solid tumors in a phase I st...
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Article
Longitudinal analysis of liver transplant candidates for hepatocellular carcinoma in a single center
Wailitst lost is an critical issue and we investigated the long-term effect of insufficient liver functional reserve at liver transplantation evaluation on waitlist outcomes in patients with hepatocellular car...
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Article
Peripheral NK cells identified as the predictor of response in extensive-stage small cell lung cancer patients treated with first-line immunotherapy plus chemotherapy
Although immunotherapy improves outcomes in extensive-stage small-cell lung cancer (ES-SCLC), the search for biomarkers predicting treatment success is crucial. Natural killer (NK) cells are potential indicato...
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Article
Open AccessCompact meta-differentiator for achieving isotropically high-contrast ultrasonic imaging
Ultrasonic imaging is crucial in the fields of biomedical engineering for its deep penetration capabilities and non-ionizing nature. However, traditional techniques heavily rely on impedance differences within...
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Article
The effectiveness of digital psychosocial interventions on psychological distress, depression, anxiety, and health-related quality of life in patients with gynaecological cancer: a systematic review and meta-analysis
Patients with gynaecological cancer often experience psychological issues due to multiple stressors. Psychological disturbances have debilitating effects on patients with gynaecological cancer. In recent decad...
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Article
Vacuum Dewatering Behaviours of Municipal Sewage Sludge
Vacuum dewatering tests for sewage sludge were conducted to investigate the effects of initial water content, quartz sand conditioning sludge and vacuum load on dewatering behaviours. Water content and settlem...
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Article
Open AccessAdvanced brain aging in Parkinson’s disease with cognitive impairment
Patients with Parkinson’s disease and cognitive impairment (PD-CI) deteriorate faster than those without cognitive impairment (PD-NCI), suggesting an underlying difference in the neurodegeneration process. We ...
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Article
Open AccessAnalysis of related factors for neuropsychiatric comorbidities in children with epilepsy
To analyze the risk factors affecting psychiatric behavior and study the psychobehavioral conditions of children with epilepsy.
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Article
Open AccessValidity of Markovian modeling for transient memory-dependent epidemic dynamics
The initial transient phase of an emerging epidemic is of critical importance for data-driven model building, model-based prediction of the epidemic trend, and articulation of control/prevention strategies. Qu...
