784 Result(s)
within
Biomedicine, general
**g Si
-
Article
Long-term culture of human esophageal explants and cells
Human esophageal epithelium obtained from intermediate autopsies (<12 h) was maintained as cell and explant cultures. In order to develop a serum-free, defined media culture model, several medias and additives...
-
Article
Products of vasopressin gene expression in small-cell carcinoma of the lung
Small-cell neuroendocrine carcinoma of the lung is known to express products related to the vasopressin gene, although these products have been reported to sometimes differ from those generated by neurones of ...
-
Article
Tumour necrosis factor-α induces an increase in susceptibility of human glioblastoma U87-MG cells to natural killer cell-mediated lysis
The mechanism by which tumour necrosis factor (TNF)-alpha increases the susceptibility of U87-MG human glioblastoma cells to lysis by natural killer (NK) cells was studied. Treatment with TNF-alpha (100 units ...
-
Article
n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines
The type rather than the amount of dietary fat may be more important in breast carcinogenesis. While animal studies support this view, little is known about the effects of essential fatty acids (EFAs) at the c...
-
Article
Prevalence of human papillomavirus DNA sequences in an area with very high incidence of cervical carcinoma
To improve our understanding of the relationship and possible associations between human papillomavirus (HPV) infection and the development of cervical malignancies, the presence of multiple types of HPV DNA s...
-
Article
Mutations in the 180–kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa
Junctional epidermolysis bullosa (JEB) is a heterogeneous autosomal recessively inherited blistering skin disorder associated with fragility at the dermal-epidermal junction1. Characteristic ultrastructural findi...
-
Article
Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer
The development of familial and sporadic breast cancer is based on genetic alterations of tumour-suppressor genes, for which loss of heterozygosity (LOH) is one mechanism of gene inactivation. To investigate L...
-
Article
Spinal canal obstruction detected by cerebrospinal fluid imaging
-
Article
Defective post–thymic tolerance mechanisms during the chronic progressive stage of multiple sclerosis
We have recently isolated a panel of T–cell clones from chronic progressive multiple sclerosis (MS) patients that are capable of functioning as antigen–presenting cells and of expressing the costimulatory mole...
-
Article
A new class of antigen-specific killer cells
A new class of antigen-specific killer cells that combines the features of antibody-mediated and cell-mediated immunity was designed. The principle and feasibility of this strategy are illustrated by creating ...
-
Article
Induction of anti-tumour lymphocytes in cancer patients after brief exposure to supernatants from cultures of anti-CD3-stimulated allogeneic lymphocytes
The present study investigated the ability of supernatants collected from cultures of healthy donor-derived peripheral blood mononuclear cells (HD-PBMCs) stimulated with anti-CD3 monoclonal antibody (MAb) (all...
-
Article
Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy
CXC-chemokine receptor (CXCR)-4/fusin, a newly discovered co-receptor for T-cell line (T)-tropic HIV-1 virus, plays a critical role in T-tropic virus fusion and entry into permissive cells. The occurrence of T...
-
Article
Microencapsulated octreotide pamoate in advanced gastrointestinal and pancreatic cancer: a phase I study
Fourteen patients suffering from advanced colorectal (n = 7), pancreatic (n = 4) or gastric (n = 3) carcinomas received treatment with microencapsulated octreotide pamoate 90 mg i.m. every 4 weeks (n = 4), 160...
-
Article
In vitro inhibition of human malignant brain tumour cell line proliferation by anti-urokinase-type plasminogen activator monoclonal antibodies
A brain tumour-associated marker, urokinase (UK), was investigated using rabbit anti-UK polyclonal and murine anti-UK monoclonal antibodies, which were prepared by immunization with low molecular weight UK (LM...
-
Article
Use of prostatic massage in combination with antibiotics in the treatment of chronic prostatitis
Chronic prostatitis is often refractory to antibiotics, however biopsy and molecular data indicate persistent symptoms may be due to occult infection. Combining antibiotic therapy with regular prostatic massag...
-
Article
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
Methylation of CpG islands is associated with transcriptional silencing and the formation of nuclease-resistant chromatin structures enriched in hypoacetylated histones1,2,3. Methyl-CpG-binding proteins, such as ...
-
Article
The First Successful Prenatal Diagnosis on a Korean Family with Citrullinemia
DNA prenatal diagnosis was successfully performed on a family with citrullinemia. The father carried the G324S mutation and the mother carried the IVS6–2A > G mutation in the argininosuccinate synthase gene. T...
-
Article
Open AccessEffect of metal ions on the stability of metallothionein in the degradation by cellular fractions in vitro
Metallothioneins (MT), small molecular weight metal binding proteins are known to play an important protective role against heavy metal toxicity, either as antioxidants or pre-oxidants. However, the mode of me...
-
Article
Open AccessFree radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root
The extract from Smilax china root has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic acitivities. In this study, a possible presence of antioxidant activity of Smilax chi...
-
Article
Open AccessAntioxidant activity of extracts from Euryale ferox seed
Euryale ferox has been widely used in traditional oriental medicine to treat a variety of illness. However, very little is known about the cellular actions by which this plant mediates its therapeutic effects....
