129 Result(s)

Article

Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer

Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...

Ya-nan Zheng, Si-yue Lou, Jun Lu, Fan-li Zheng, Yong-mei Tang… in Cell Death & Disease (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease

Ubiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD). However, the crosstalk between deubiquitinating enzyme (DUB...

Liuyan Ding, Lin Lu, Shaohui Zheng, Zhiling Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Hepatic Sirt6 activation abrogates acute liver failure

Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...

**que Luo, Huan Liu, Yanni Xu, Nanhui Yu, Rebbeca A. Steiner… in Cell Death & Disease (2024)

Article

Correction: Clinical-mediated discovery of pyroptosis in CD8⁺ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Ying Zhang, Yun Bai, **ao-Xuan Ma, Jian-Kun Song, Yue Luo… in Cell Death & Disease (2024)

Article

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to ...

Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, **aohua Chen, Boyi Yu… in Cell Death & Disease (2024)

Article

Exosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells

Early metastasis is the primary factor in the very poor prognosis of pancreatic ductal adenocarcinoma (PDAC), with liver metastasis being the most common form of distant metastasis in PDAC. To investigate the ...

Wei Chen, Wang Peng, Ronghua Wang, Shuya Bai, Mengdie Cao, Si **ong… in Cell Death & Disease (2024)

Article

The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3

The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process an...

Siyu Zhao, Yunyi Hu, Bicheng Yang, Lichao Zhang, Meiyining Xu… in Cell Death & Disease (2024)

Article

Mechanisms and effects of NLRP3 in digestive cancers

Inflammasomes are thought to be important mediators of host defense against microbial pathogens and maintenance of gastrointestinal tract homeostasis. They can modulate caspase-1 to promote IL-18 and IL-1β sec...

Yuxin Si, Lei Liu, Zhe Fan in Cell Death Discovery (2024)

Article

Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation

Obesity, a worldwide epidemic in recent years, is mainly due to the uncontrolled development of adipose tissues, which includes adipocyte hypertrophy and hyperplasia. Adipocyte differentiation is a process inv...

Leilei Sun, Shao** Ji, Xuan **e, Lei Si, Shaohao Liu, Yao Lin… in Cell Death & Disease (2023)

Article

PDPN⁺ CAFs facilitate the motility of OSCC cells by inhibiting ferroptosis via transferring exosomal lncRNA FTX

Cancer-associated fibroblasts (CAFs) are abundant and heterogeneous in tumor microenvironment (TME). Cross-talk between cancer cells and CAFs results in cancer progression. Here, we demonstrated that a distinc...

Yaoyin Li, Zeyi Ma, Weiyu Li, **aoqing Xu, Peiqi Shen, Si-en Zhang… in Cell Death & Disease (2023)

Article

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated ...

Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, **an Liu… in Cell Death & Disease (2023)

Article

Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane

Defects in plasma membrane repair can lead to muscle and heart diseases in humans. Tripartite motif-containing protein (TRIM)72 (mitsugumin 53; MG53) has been determined to rapidly nucleate vesicles at the sit...

Si Hoon Park, Juhyun Han, Byung-Cheon Jeong… in Nature Structural & Molecular Biology (2023)

Article

ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma

Zinc finger protein 281 (ZNF281) has been shown to promote tumor progression. However, the underlying mechanism remains to be further elucidated. In this study, ZNF281 knockdown increased the expression of mit...

Qingfang Zhao, Chenguang Zhang, **alu Zhang, Shanshan Wang… in Cell Death Discovery (2023)

Article

PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming

PTP4A1 (Protein tyrosine phosphatase 4A1) is a protein tyrosine phosphatase that regulates a range of pro-oncogenic signaling pathways. Here, we report a novel role for PTP4A1 in oral squamous cell carcinoma (...

Bing Liu, Wen Si, Bo Wei, Xuan Zhang, Peng Chen in Cell Death Discovery (2023)

Article

Clinical-mediated discovery of pyroptosis in CD8⁺ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Histologically, melanoma tissues had fewer positive cells percentage of pyroptosis-related genes (PRGs), GZMA, GSDMB, NLRP1, IL18, and CHMP4A in epidermal than in normal skin. Pyroptosis, a new frontier in can...

Ying Zhang, Yun Bai, **ao-Xuan Ma, Jian-Kun Song, Yue Luo… in Cell Death & Disease (2023)