274 Result(s)

Article

Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer

Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...

Ya-nan Zheng, Si-yue Lou, Jun Lu, Fan-li Zheng, Yong-mei Tang… in Cell Death & Disease (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels

Myocardial infarction (MI) results in prolonged ischemia and the subsequent cell death leads to heart failure which is linked to increased deaths or hospitalizations. New therapeutic targets are urgently neede...

Hengshu Chen, Si Wang, **aoling Zhang, **ng Hua… in Functional & Integrative Genomics (2024)

Article

Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease

Ubiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD). However, the crosstalk between deubiquitinating enzyme (DUB...

Liuyan Ding, Lin Lu, Shaohui Zheng, Zhiling Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Spatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation

Anorectal malformation (ARM) is a prevalent early pregnancy digestive tract anomaly. The intricate anatomy of the embryonic cloaca region makes it challenging for traditional high-throughput sequencing methods...

Chen-Yi Wang, Mu-Yu Li, Si-Ying Li, **ao-Gao Wei… in Cell Biology and Toxicology (2024)

Article

Hepatic Sirt6 activation abrogates acute liver failure

Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...

**que Luo, Huan Liu, Yanni Xu, Nanhui Yu, Rebbeca A. Steiner… in Cell Death & Disease (2024)

Article

The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice

Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related...

Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao… in Cellular & Molecular Biology Letters (2024)

Article

miR-324-3p Suppresses Hepatic Stellate Cell Activation and Hepatic Fibrosis Via Regulating SMAD4 Signaling Pathway

In hepatic fibrosis (HF), hepatic stellate cells (HSCs) form the extracellular matrix (ECM), and the pathological accumulation of ECM in the liver leads to inflammation. Our previous research found that miR-32...

Si-Yu Chen, **n Chen, Sai Zhu, **-** Xu, **ao-Feng Li… in Molecular Biotechnology (2024)

Article

Correction: Clinical-mediated discovery of pyroptosis in CD8⁺ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Ying Zhang, Yun Bai, **ao-Xuan Ma, Jian-Kun Song, Yue Luo… in Cell Death & Disease (2024)

Article

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to ...

Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, **aohua Chen, Boyi Yu… in Cell Death & Disease (2024)

Article

Exosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells

Early metastasis is the primary factor in the very poor prognosis of pancreatic ductal adenocarcinoma (PDAC), with liver metastasis being the most common form of distant metastasis in PDAC. To investigate the ...

Wei Chen, Wang Peng, Ronghua Wang, Shuya Bai, Mengdie Cao, Si **ong… in Cell Death & Disease (2024)

Article

The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3

The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process an...

Siyu Zhao, Yunyi Hu, Bicheng Yang, Lichao Zhang, Meiyining Xu… in Cell Death & Disease (2024)

Article

Mechanisms and effects of NLRP3 in digestive cancers

Inflammasomes are thought to be important mediators of host defense against microbial pathogens and maintenance of gastrointestinal tract homeostasis. They can modulate caspase-1 to promote IL-18 and IL-1β sec...

Yuxin Si, Lei Liu, Zhe Fan in Cell Death Discovery (2024)