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Article
A systematic review of penetrating perineal trauma in a civilian setting
Penetrating injuries to the perineum and associated pelvic organs have largely been reported in the military. Given the rarity of presentation and unique clinical characteristics of these injuries, we set out ...
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Article
Open AccessDeciphering lipid dysregulation in ALS: from mechanisms to translational medicine
Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols. Lipids not only regulat...
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Article
Open AccessA conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs
The Notch pathway is a conserved cell-cell communication pathway that controls cell fate decisions. Here we sought to determine how Notch pathway activation inhibits the neuroendocrine cell fate in the lungs, ...
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Article
Validation of the Malay version of the p-QOL questionnaire
This study aimed to translate and validate the P-QOL questionnaire in the Malay language.
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Article
Open AccessAssessment of aPTT-based clot waveform analysis for the detection of haemostatic changes in different types of infections
Infections cause varying degrees of haemostatic dysfunction which can be detected by clot waveform analysis (CWA), a global haemostatic marker. CWA has been shown to predict poor outcomes in severe infections ...
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Article
Open AccessThe predominant learning approaches of medical students
By identifying medical students’ learning approaches and the factors that influence students’ learning approaches, medical schools and health care institutions are better equipped to intervene and optimize the...
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Chapter
Ageing Hair in Asians and Caucasians
Hair differs across ethnicities and in changes with age. While limited, most literature agree that Asian ethnicities grey later than Caucasians, beginning at least 5 years later and perhaps regionally more. Th...
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Article
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
In a mouse model of small-cell lung cancer and in human tumours, activation of the Notch pathway can lead to a cell fate switch of neuroendocrine cells to less proliferative non-neuroendocrine cells, generatin...
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Article
Carbon nanoparticle modified screen printed carbon electrode as a disposable electrochemical immunosensor strip for the detection of Japanese encephalitis virus
The authors describe a disposable electrochemical immunosensor strip for the detection of the Japanese encephalitis virus (JEV). The assay is based on the use of a screen printed carbon electrode (SPCE) modifi...
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Article
Comprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex g...
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Article
Update on the management of ovarian torsion in children and adolescents
Ovarian torsion is commonly seen in young girls. Unfortunately it is often misdiagnosed because of its non-specific symptoms and lack of diagnostic modalities. This article focuses on the diagnostic challenge ...
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Article
Outpatient versus inpatient intravaginal misoprostol for the treatment of first trimester incomplete miscarriage: a randomised controlled trial
Study objective To assess the efficacy of outpatient misoprostol administration versus inpatient misoprostol administration for the treatment of first trimester incomplete miscarriage.
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Article
Umbilical vein oxytocin in the management of retained placenta: an alternative to manual removal of placenta?
Retained placenta is potentially life threatening due to possible complications associated with manual removal. Our aim was to determine whether umbilical vein injection of oxytocin in saline reduces the need ...
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Article
Establishment of Cyperus aromaticus cell suspension cultures for the production of Juvenile hormone III
Cell suspension cultures of Cyperus aromaticus were established from the yellow friable callus derived from the root explants of in vitro plantlets. Four callus cell lines were selected based on their growth inde...
