220 Result(s)
within
**g Cheng Zhang
Life Sciences
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Article
Morphology-based genetic diversity analysis reveals introgressive hybridizations obscure species boundaries of three wild roses endemic to Taiwan Island
Interspecific hybridization in the genus Rosa (Rosaceae) is a common natural phenomenon. Hybrids often exhibit heterosis and new combinations of traits, which can provide raw materials for horticultural breeding....
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Article
Open AccessPyroptosis and mitochondrial function participated in miR-654-3p-protected against myocardial infarction
Myocardial infarction (MI) is one of the leading causes of heart failure with highly complicated pathogeneses. miR-654-3p has been recognized as a pivotal regulator of controlling cell survival. However, the f...
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Article
Open AccessAerobic glycolysis of vascular endothelial cells: a novel perspective in cancer therapy
Vascular endothelial cells (ECs) are monolayers of cells arranged in the inner walls of blood vessels. Under normal physiological conditions, ECs play an essential role in angiogenesis, homeostasis and immune ...
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Open AccessThe NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif
PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...
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Article
Effects of glycerol monolaurate on estradiol and follicle-stimulating hormones, offspring quality, and mRNA expression of reproductive-related genes of zebrafish (Danio rerio) females
This study aims to explore whether glycerol monolaurate (GML) can improve reproductive performance of female zebrafish (Danio rerio) and the survival percentage of their offspring. Three kinds of isonitrogenous a...
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Article
Open AccessStructure and immunostimulating activity of polysaccharides derived from the roots and leaves of dandelion
Two polysaccharides were obtained from dandelion roots (DPR) and dandelion leaves (DPL) via water extraction and ethanol precipitation. Both DPR and DPL were an acid heteropolysaccharide, with a molecular weig...
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Article
Open AccessDrug repositioning for immunotherapy in breast cancer using single-cell analysis
Immunomodulatory peptides, while exhibiting potential antimicrobial, antifungal, and/or antiviral properties, can play a role in stimulating or suppressing the immune system, especially in pathological conditi...
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Article
Open AccessmiR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism
The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles of PDZK1 in HCC are unclear. Therefore, the aim of this study is to explore the role an...
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Article
Open AccessDual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice
Prostatitis is a highly prevalent condition that seriously affects men’s physical and mental health. Although epidemiological investigations have provided evidence of a correlation between insufficient sleep a...
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Article
Identification of FDA-approved drugs that induce heart regeneration in mammals
Targeting Meis1 and Hoxb13 transcriptional activity could be a viable therapeutic strategy for heart regeneration. In this study, we performd an in silico screening to identify FDA-approved drugs that can inhi...
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Open AccessRetraction Note: Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma
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Article
Open AccessClaudin-18.2 mediated interaction of gastric Cancer cells and Cancer-associated fibroblasts drives tumor progression
Claudin-18.2 (CLDN18.2) has emerged as an alluring therapeutic target against gastrointestinal tumors in recent years. However, a thorough understanding of its regulatory mechanism in gastric cancer remains el...
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Article
Open AccessMYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription
The abnormality of chromosomal karyotype is one factor causing poor prognosis of lymphoma. In the analysis of abnormal karyotype of lymphoma patients, three smallest overlap regions were found, in which MYCT1 ...
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Article
Structural basis of branching during RNA splicing
Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome structures have led to competing models for the recognition of the invariant adenosine at the bra...
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Small RNA and DNA Methylation of Tea Plants
Small RNAs are a category of short noncoding RNAs (ncRNAs) with 18–30 nt lengths. Based on their function and mechanisms of biogenesis, these small RNAs be classified into three major classes—microRNAs (miRNAs...
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Article
Production of all-male non-transgenic zebrafish by conditional primordial germ cell ablation
Many fish species exhibit remarkable sexual dimorphism, with males possessing numerous advantageous traits for commercial production by aquaculture such as faster growth rate, more efficient food energy utiliz...
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Article
An epi-allele of SMS causes Sanming dominant genic male sterility in rice
Male sterility is an important trait in rice for hybrid rice (Oryza sativa) breeding. However, the factors involved in dominant male sterility are largely unknown. Here, we identified a gene from Sanming dominant...
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Article
PSKR1 balances the plant growth–defence trade-off in the rhizosphere microbiome
Microbiota benefit their hosts by improving nutrient uptake and pathogen protection. How host immunity restricts microbiota while avoiding autoimmunity is poorly understood. Here we show that the Arabidopsis phyt...
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Article
Open AccessComprehensive analysis of miRNA-mRNA regulatory pairs associated with colorectal cancer and the role in tumor immunity
MicroRNA (miRNA) which can act as post-transcriptional regulators of mRNAs via base-pairing with complementary sequences within mRNAs is involved in processes of the complex interaction between immune system a...
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Open AccessInterleukin 4 improved adipose-derived stem cells engraftment via interacting with fibro/adipogenic progenitors in dystrophic mice
Adipose-derived stem cells (ADSC) therapy shows promise as an effective treatment for dystrophinopathy. Fibro-/adipogenic progenitors (FAPs) play an essential role in the myogenesis of muscle satellite cells a...
