328 Result(s)
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Article
KIAA1429 promotes the malignancy of oral squamous cell carcinoma by regulating CA9 m6A methylation
KIAA1429 has been reported as a cancer regulator, but its role and mechanism in the progression of oral squamous cell carcinoma (OSCC) remain elusive. The objective of the present research was to figure out th...
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Article
miR-1-3p Inhibits Osteosarcoma Cell Proliferation and Cell Cycle Progression While Promoting Cell Apoptosis by Targeting CDK14 to Inactivate Wnt/Beta-Catenin Signaling
Osteosarcoma (OS) is a common bone malignancy and is diagnosed frequently in children and young adults. According to previous RNA sequencing, miR-1-3p is downregulated in OS clinical samples. Nevertheless, the...
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Article
Efficient production of polyhydroxybutyrate using lignocellulosic biomass derived from oil palm trunks by the inhibitor-tolerant strain Burkholderia ambifaria E5-3
Lignocellulosic biomass is a valuable, renewable substrate for the synthesis of polyhydroxybutyrate (PHB), an ecofriendly biopolymer. In this study, bacterial strain E5-3 was isolated from soil in Japan; it wa...
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Article
Cocrystal Prediction of Nifedipine Based on the Graph Neural Network and Molecular Electrostatic Potential Surface
Nifedipine (NIF) is a dihydropyridine calcium channel blocker primarily used to treat conditions such as hypertension and angina. However, its low solubility and low bioavailability limit its effectiveness in ...
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Article
Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents
Bispecific and multispecific agents have become increasingly utilized in cancer treatment and immunotherapy, yet their complex design parameters present a challenge in develo** successful therapeutics. Bispe...
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Article
Wide-Angle Broadband Solar Absorber Based on Multilayer Etched Toroidal Structure
In this study, we propose a wide-angle broadband solar absorber based on multilayer etched toroidal structure. It is composed of a top layer Ti, W, and Si3N4 multilayer material, a silica insulator, and a Ti subs...
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Article
Immunological Roles of CCL18 in Pan‑Cancer and Its Potential Value in Endometrial Cancer
Endometrial cancer (EC) is one of the most prevalent malignancies in the female reproductive system. However, the potential functions and mechanisms of immune-related genes in the onset and progression of EC r...
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Article
Improving Intestinal Barrier Function in Sepsis by Partially Hydrolysed Guar Gum via the Suppression of the NF-κB/MLCK Pathway
Partially hydrolyzed guar gum (PHGG) protects against intestinal barrier dysfunction and can ameliorate some intestinal diseases. However, whether PHGG has a role in protecting intestinal barrier function (IBF...
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Article
A High-Gain Tapered Slot Antenna Based on Spoof Surface Plasmon Polaritons Director and Horn-Shaped Dielectric Lens
In this paper, a high-gain tapered slot antenna is proposed by adopting a spoof surface plasmon polaritons (SSPPs) director and a horn-shaped dielectric lens. Firstly, a horn-shaped dielectric lens is designed...
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Article
Open AccessEmerging microalgal feed additives for ruminant production and sustainability
The global demand for animal-derived foods has led to a substantial expansion in ruminant production, which has raised concerns regarding methane emissions. To address these challenges, microalgal species that...
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Open AccessNLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...
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Article
An Advanced Molecularly Imprinted Photochemical Sensor Based Carbon Quantum dots for Highly Sensitive Detection of Chloramphenicol in Food
A facile method which combines the advantages of carbon quantum dots and molecular imprinting technology to design a fluorescence molecular imprinting sensor for the high sensitivity and selective detection of...
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Article
Rod-shaped hollow mesoporous silica drug delivery system: synthetic design, ibuprofen delivery, and optical imaging
In this work, we proposed a synthesis strategy for a novel drug delivery system (DDS) composed of rod-shaped hollow mesoporous silica core and luminescent Gd2O3:Eu shell. This interesting nanostructure combines t...
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Article
Open AccessSialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian cancer. Glycoconjugates are highly expressed on sEV and play important roles in sEV biog...
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Article
Non-enzymatic Detection of Uric Acid in Serum and Urine by Fluorescent and Visual Dual-Mode Sensor Based on 3-aminophenylboric Acid Functionalized Carbon Dots
Herein, we developed a sophisticated dual-mode sensor that utilized 3-aminophenylboric acid functionalized carbon dots (APBA-CDs) to accurately detect uric acid (UA). Our innovative process involved synthesizi...
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Article
Quantitative trait loci detection for three tiller-related traits and the effects on wheat (Triticum aestivum L.) yields
A total of 38 putative additive QTLs and 55 pairwise putative epistatic QTLs for tiller-related traits were reported, and the candidate genes underlying qMtn-KJ-5D, a novel major and stable QTL for maximum tiller...
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Article
Open AccessMRE11A: a novel negative regulator of human DNA mismatch repair
DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attributed to the development of various types of cancers. Although well characterized, MMR fa...
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Article
Profiling the selected hotspots for ear traits in two maize–teosinte populations
Eight selected hotspots related to ear traits were identified from two maize–teosinte populations.
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Article
Functionalized Green Carbon dots for Specific Detection of Copper in Human Serum Samples and Living Cells
Intracellular copper ion (Cu2+) is irreplaceable and essential in regulation of physiological and biological processes, while excessive copper from bioaccumulation may cause potential hazards to human health. Hen...
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Article
Elevated Level of PINK1/Parkin-Mediated Mitophagy Pathway Involved to the Inhibited Activity of Mitochondrial Superoxide Dismutase in Rat Brains and Primary Hippocampal Neurons Exposed to High Level of Fluoride
To reveal the molecular mechanism of brain damage induced by chronic fluorosis, expression of PTEN-induced kinase 1 (PINK1)/parkin RBR E3 ubiquitin-protein ligase (Parkin)-mediated mitophagy pathway and activi...
