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758 Result(s)
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Article
Rutin Ameliorates Toxoplasma gondii-Induced Brain Tissue Damage via Inhibiting P2X7R/NLRP3 Pro-Inflammatory and Enhancing PI3K/AKT/Nrf2/HO-1 Antioxidant Signaling Pathway
Bain damage caused by Toxoplasma gondii (T. gondii) is associated with increased inflammatory response and oxidative stress. Rutin, a natural product extracted from tobacco leaves and tomatoes, has excellent anti...
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Open AccessTracking the hologenome dynamics in aquatic invertebrates by the holo-2bRAD approach
The “hologenome” concept is an increasingly popular way of thinking about microbiome-host for marine organisms. However, it is challenging to track hologenome dynamics because of the large amount of material, ...
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Screening of Strain from Reconstituted Sheet Tobacco Making High-Yield Enzyme and Aroma
Reconstituted sheet tobacco (RST) is critical to the quality of cigarette. The purpose of this study was to extract and cultivate bacteria from tobacco leaf stalks, scraps, and concentrate from RST production ...
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Open AccessA broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug
SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain. Blocking this interaction has been proven to be an ...
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Open AccessLIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism
LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...
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Open AccessDeciphering spatial domains from spatial multi-omics with SpatialGlue
Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integr...
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Open AccessGenome-wide identification of ATG genes and their expression profiles under biotic and abiotic stresses in Fenneropenaeus chinensis
Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. Extensive research has shown that autophagy pl...
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Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption
Alcohol use disorder (AUD) affects millions of people worldwide, causing extensive morbidity and mortality with limited pharmacological treatments. The liver is considered as the principal site for the detoxif...
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Open AccessHippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity
Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...
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Open AccessEnvironment influences the genetic structure and genetic differentiation of Sassafras tzumu (Lauraceae)
Sassafras tzumu, an elegant deciduous arboreal species, belongs to the esteemed genus Sassafras within the distinguished family Lauraceae. With its immense commercial value, escalating market demands and unforese...
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Open AccessCrowd-sourced benchmarking of single-sample tumor subclonal reconstruction
Subclonal reconstruction algorithms use bulk DNA sequencing data to quantify parameters of tumor evolution, allowing an assessment of how cancers initiate, progress and respond to selective pressures. We launc...
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Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
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Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
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Mammalian IRE1α dynamically and functionally coalesces with stress granules
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) initiates a key branch of the unfolded protein response (U...
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Open AccessAging atlas reveals cell-type-specific effects of pro-longevity strategies
Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes di...
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Open AccessHAX-1 interferes in assembly of NLRP3-ASC to block microglial pyroptosis in cerebral I/R injury
Acute cerebral ischemia has a high rate of disability and death. Although timely recanalization therapy may rescue the ischemic brain tissue, cerebral ischemia-reperfusion injury has been shown to limit the th...
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Open AccessSingle-cell transcriptomic landscape and the microenvironment of normal adjacent tissues in hypopharyngeal carcinoma
The cellular origin of hypopharyngeal diseases is crucial for further diagnosis and treatment, and the microenvironment in tissues may also be associated with specific cell types at the same time. Normal adjac...
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Conserving the primary forests in the Yarlung Tsangpo Grand Canyon for people and nature
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Genetically optimizing soybean nodulation improves yield and protein content
Symbiotic nitrogen fixation in legume nodules requires substantial energy investment from host plants, and soybean (Glycine max (L.) supernodulation mutants show stunting and yield penalties due to overconsumptio...
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Open AccessIdentification and affinity enhancement of T-cell receptor targeting a KRASG12V cancer neoantigen
Neoantigens derived from somatic mutations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), the most frequently mutated oncogene, represent promising targets for cancer immunotherapy. Recent research high...