9 Result(s)
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Article
Open AccessTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted b...
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Clinical and functional consequences of GRIA variants in patients with neurological diseases
AMPA receptors are members of the glutamate receptor family and mediate a fast component of excitatory synaptic transmission at virtually all central synapses. Thus, their functional characteristics are a crit...
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Article
Comparing the effectiveness of R genes in a 2-year canola–wheat rotation against Leptosphaeria maculans, the causal agent of blackleg disease in Brassica species
Blackleg, which is caused by the ascomycete fungus Leptosphaeria maculans, is a major disease of canola in Canada and worldwide. In Canada, canola is usually grown in rotation once every three to four years to li...
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Open AccessIdentification of resistance loci in Chinese and Canadian canola/rapeseed varieties against Leptosphaeria maculans based on genome-wide association studies
The fungal pathogen Leptosphaeria maculans (Lm). causes blackleg disease on canola/rapeseed in many parts of the world. It is important to use resistant cultivars to manage the disease and minimize yield losses. ...
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Open AccessPlant composition changes in a small-scale community have a large effect on the performance of an economically important grassland pest
The grasshopper Oedaleus asiaticus Bey-Bienko (Acrididae: Oedipodinae) is a dominant and economically important pest that is widely distributed across the Mongolian plateau. This herbivore pest causes major damag...
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Open AccessComparative transcriptomic analysis of resistant and susceptible alfalfa cultivars (Medicago sativa L.) after thrips infestation
Plant breeding for resistance to agricultural pests is an essential element in the development of integrated crop management systems; however, the molecular and genetic mechanisms underlying resistance are poo...
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Breakdown of Rlm3 resistance in the Brassica napus–Leptosphaeria maculans pathosystem in western Canada
Blackleg disease, caused by the fungal pathogen Leptosphaeria maculans, is a serious disease of Brassica napus. The disease is mainly controlled by genetic resistance and crop rotation. However, L. maculans has d...
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Open AccessPostzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals
Postzygotic single-nucleotide mutations (pSNMs) have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkabl...
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Open AccessAnalysis of the genomic sequence of Philosamia cynthia nucleopolyhedrin virus and comparison with Antheraea pernyinucleopolyhedrin virus
Two species of wild silkworms, the Chinese oak silkworm (Antheraea pernyi) and the castor silkworm Philosamia cynthia ricini, can acquire a serious disease caused by Nucleopolyhedrin Viruses (NPVs) (known as Anpe...
