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  1. No Access

    Article

    Mammalian PIWI–piRNA–target complexes reveal features for broad and efficient target silencing

    The PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome inte...

    Zhiqing Li, Zhenzhen Li, Yuqi Zhang, Lunni Zhou… in Nature Structural & Molecular Biology (2024)

  2. Article

    Open Access

    Correction: CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

    **n-Yuan Lyu, Yuan Deng, **ao-Yan Huang, Zhen-Zhen Li, Guo-Qing Fang… in Cell Research (2022)

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  3. Article

    Open Access

    CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

    The dynamic three-dimensional structures of chromatin and extrachromosomal DNA molecules regulate fundamental cellular processes and beyond. However, the visualization of specific DNA sequences in live cells, ...

    **n-Yuan Lyu, Yuan Deng, **ao-Yan Huang, Zhen-Zhen Li, Guo-Qing Fang… in Cell Research (2022)

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  4. Article

    Open Access

    Identification of transcriptome and fluralaner responsive genes in the common cutworm Spodoptera litura Fabricius, based on RNA-seq

    Fluralaner is a novel isoxazoline insecticide with a unique action site on the γ-aminobutyric acid receptor (GABAR), shows excellent activity on agricultural pests including the common cutworm Spodoptera litura, ...

    Zhong-Qiang Jia, Di Liu, Ying-Chuan Peng, Zhao-Jun Han, Chun-Qing Zhao… in BMC Genomics (2020)

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  5. No Access

    Article

    Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice

    Diseases caused by different mutations in the two alleles of a gene are treated in mice by Cas-9-induced allelic exchange.

    Dan Wang, Jia Li, Chun-Qing Song, Karen Tran, Haiwei Mou… in Nature Biotechnology (2018)

  6. No Access

    Article

    Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

    Efficient Cas9 genome editing in vivo is achieved without viral vectors using chemically modified single-guide RNAs.

    Hao Yin, Chun-Qing Song, Sneha Suresh, Qiongqiong Wu, Stephen Walsh… in Nature Biotechnology (2017)

  7. No Access

    Article

    Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

    Cas9-mediated gene editing corrects hereditary tyrosinemia in a mouse model.

    Hao Yin, Chun-Qing Song, Joseph R Dorkin, Lihua J Zhu, Yingxiang Li… in Nature Biotechnology (2016)

  8. No Access

    Article

    Factors determining species displacement of related predatory mite species (Acari: Phytoseiidae)

    Neoseiulus womersleyi (Acari: Phytoseiidae) used to be the dominant species in fruit-tree orchards throughout Japan, but starting in the 1990s, N. womersleyi began to be displaced by Neoseiulus c...

    Tetsuo Gotoh, Masumi Hanawa, Sayaka Shimazaki… in Experimental and Applied Acarology (2014)

  9. No Access

    Article

    Free volume properties of interpenetrating polymer networks probed by positron annihilation

    He Chun-qing, Dai Yi-qun, Zhang Shao-**… in Wuhan University Journal of Natural Scienc… (2000)