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Molecular Medicine
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Article
Open AccessEffect of protein kinase C, calcium and cAMP on the expression of proto-oncogens, pRb and cell proliferation
The second messengers induced by growth factors are thought to have important roles in transducing the growth factor signals to nuclear events and cell proliferation. Various second messengers stimulate expres...
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Open AccessStudies on inhibition of glyoxalase II by synthetic and natural products
Inhibitors of glyoxalse I and II have been investigated as a possible approach to development of anticancer agents. In this study the effects of S-blocked glutathione derivatives and methanol-extracts of edibl...
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Open AccessEffects of cadmium on glucose transport in rat adipocytes and human erythrocytes: stimulation of GLUT1 catalytic activity
The effects of cadmium on facilitative glucose transporter function In rat adipocytes were studied. A short (30 min) incubation with cadmium resulted in stimulation of 3-O-methyl-D-glucose (3OMG ) equilibrium ...
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Open AccessAmplification and over-expression of erbB-2 oncogene in primary human breast tumors
erbB-2 is a growth factor receptor gene, and it's product, p185, has tyrosine kinase activity and can transform NIH3T3 cell when overexpressed. erbB-2 oncogene has been reported to be amplified frequently in v...
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Open AccessPresentation of human immunodeficiency virus epitopes by chimeric core particles hepatitis B virus
We have constructed a synthetic open reading frame based on amino acid sequences from two conserved regions of the HIV-1 p120 env protein, and from a predicted antigenic region of the p17 gag protein. We have ...
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Open Accessγ-Glutamyltransferase in adult rat hepatocyte during proliferation
γ-Glutamyltransferase (GGT) activity is known to increase during hepatocarcinogenesis induced by chemical carcinogens. To understand the possible significance of GGT, we have investigated GGT activities in hep...
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Open AccessChanges of gangliosides and sialic acid in human milk during lactation
To elucidate the possible biological function of gangliosides in human milk, the content and composition of gangliosides in human milk during lactation were examined. Gangliosides were rich in human milk at th...
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Open AccessA direct sandwich enzyme-linked limmunosorbent assay for human serum apolipoprotein A-I
Apolipoprotein (apo) A-I, an abundant protein in high-density lipoproteins (HDL), has received considerable clinical attention as a negative predictor of coronary artery disease, because the plasma concentrati...
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Open AccessThe WW domain binds polyprolines and is involved in human diseases
Our study of transforming genes led us to the identification of a new protein module, the WW domain, that is found in a wide range of structural, regulatory and signaling proteins. The WW domain is functionall...
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Open AccessEffects of mutation at arginine-218 residue on the reaction of synthetic thymidylate synthase and 5-fluorouracil
The importance of Arg-218 residue for the catalytic activity of thymidylate synthase chemically synthesized based on the amino acid sequence of thymidylate synthase from Lactobacillus casei has been studied by...
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Open AccessInhibition of hemoglobin-induced low density lipoprotein oxidation by haptoglobin
The effects of hemoglobin (Hb) and haptoglobinhemoglobin complex (Hp-Hb complex) on oxidation of low density lipoprotein (LDL) were investigated. Treatment of LDL (100 µg protein) with 60 µg (20 µM) of Hb for ...
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Open AccessHigh-does nitric oxide induces apoptosis in HL-60 human myeloid leukemia cells
The treatment of human promyeloid leukemia cell line HL-60 cells with nitric oxide (NO) is associated with loss of proliferative apacity and induction of monocytic differentiation. The present results demonstr...
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Open AccessBovine cardiac troponin-I specific monoclonal antibodies which show species cross reactivity
Cardiac troponin-l (cTn-l) specific monoclonal antibodies (McAb) were produced against bovine cTn-l. Six somatic cell fusions using polyethylene glycol (40%) between spleen cells from cTn-l immunized mice BALB...
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Open AccessModulation of dopamine transporter functions by protein kinase C
The effects of phosphorylation on the functions of the bovine dopamine transporter (DAT) expressed in CV-1 cells were investigated. The cells expressing DAT stably were prepared by transfection of CV-1 cells (...
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Open AccessSpecies-specific hemolysis by Vibrio vulnificus cytolysin
Cytolysin has been incriminated as one of the important virulence determinants in V. vulnificus infection that causes septicemia and serious wound infection. Hemolysis by V. vulnificus cytolysin is colloid-osm...
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Open AccessIntermediate filaments in health and disease
lntermediate filaments constitute one of the major classes of cytoskeletal proteins of mammalian cells. The 40 or more known intermediate filament proteins have been classified into five types which show very ...
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Open AccessEffect of lovastatin on cholestatic liver injury induced by bile duct ligation in rats
The involvement of bile acids in hepatic damage under cholestasis and the effect of lowering bile acid level through the inhibition of microsomal 3- hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by lovastat...
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Open AccessDissociation of Rab3A by Ca(2+)/calmodulin from different kinds of synaptosomal membranes
In the previous study, we have shown that Rab3A is dissociated from synaptosomal membranes by Ca2+/calmodulin complex. In this study, we further fractionated the synaptosomal membranes by gradient centrifugati...
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Open AccessAn evidence of presence of DNA-binding proteins in selection of dystrophic gene promoter
The expression of dystrophin gene has been found to be regulated through different promoters in different tissues. To understand the mechanism of tissue specific selection of promoter DNA-protein interaction s...
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Open AccessCircumvention of drug resistance in cancer cells by a new fluoropyrimidine analogue
The potentiation of antitumor drugs by their analogues is one of strategies for overcoming cellular resistance to chemotherapy. In attempts to improve the efficacy of 5-fluorouracil (5-FU) and overcome 5-FU re...
