4,418 Result(s)
within
Biomedicine, general
Molecular Medicine
Pharmacology/Toxicology
**e **an
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Getting stuck in
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Model behaviour...
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Emerging immune targets for the therapy of allergic asthma
Despite the existence of effective therapies, allergic asthma and related atopic syndromes have recently emerged as epidemic diseases and important public heal...
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Drug discovery by dynamic combinatorial libraries
Dynamic combinatorial chemistry is a supramolecular approach that uses a self-assembly process to generate libraries of chemical compounds. Spontaneous assembl...
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High-throughput crystallography for lead discovery in drug design
Knowledge of the three-dimensional structures of target proteins provides a starting point for structure-based approaches to drug design by defining the topogr...
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Toxicogenomics and drug discovery: will new technologies help us produce better drugs?
Acting on reports in the late 1980s that most drug candidates fail in development, pharmaceutical discovery programmes responded by devising ways to increase the number of chemicals in the pipeline. With disco...
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Targeting glycosylation as a therapeutic approach
Protein and lipid glycosylation are vital to fundamental cellular processes. For therapeutic strategies that target glycosylation, modulation rather than ablat...
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In this issue
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What's your poison?
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eSCA** high cholesterol
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First class delivery
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...And fashionable screening
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Strategies in the design of antiviral drugs
Greater understanding of viral life cycles has resulted in the discovery and validation of several targets for therapeutic intervention, and an increase in the...
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The genetic basis of variability in drug responses
Variability in response to therapy is an expected feature of most drug treatments.
Pharmacokinetic variabil...
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Moving smaller in drug discovery and delivery
Advances in new micro- and nanotechnologies are accelerating the identification and evaluation of drug candidates, and the development of new delivery technologies that are required to transform biological pot...
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Cheek to cheek
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Antiviral market overview
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Insulin in disguise
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The potential for novel anti-inflammatory therapies for coronary artery disease
Although drugs that lead to cholesterol and lipid lowering have proved to have significant effects in lowering cardiovascular morbidity and mortality, coronary...
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Drug and gene targeting to the brain with molecular trojan horses
The brains of all vertebrates are protected from substances in the blood by the blood–brain barrier (BBB). Although the BBB maintains brain function under norm...
