2,060 Result(s)

Article

Metabolomics: building on a century of biochemistry to guide human health

Medical diagnosis and treatment efficacy will improve significantly when a more personalized system for health assessment is implemented. This system will require diagnostics that provide sufficiently detailed...

J. Bruce German, Bruce D. Hammock, Steven M. Watkins in Metabolomics (2005)

Article

Metabolome analysis and metabolic simulation

For many decades microorganisms have been used for industrial purposes; traditional fermentations such as brewing and production of food additives, aroma molecules, organic acids and pharmaceutical-like antibi...

Nobuyoshi Ishii, Tomoyoshi Soga, Takaaki Nishioka, Masaru Tomita in Metabolomics (2005)

Article

Comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry (GC × GC-TOF) for high resolution metabolomics: biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice

Comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry (GC × GC-TOF) was applied for the analysis of complex metabolite profiles from mouse spleen. The resulting two-dimensional chro...

Werner Welthagen, Robert A. Shellie, Joachim Spranger, Michael Ristow… in Metabolomics (2005)

Article

NMR-based metabonomic evaluation of livers from rats chronically treated with tamoxifen, mestranol, and phenobarbital

In this study, we look at the metabolic effects of long-term dosing with tamoxifen, mestranol or phenobarbital on the liver. Tamoxifen, mestranol and phenobarbital have all been reported to act as promoters of...

Laura Schnackenberg, Richard D. Beger, Yvonne Dragan in Metabolomics (2005)

Article

A metabolome pipeline: from concept to data to knowledge

Metabolomics, like other omics methods, produces huge datasets of biological variables, often accompanied by the necessary metadata. However, regardless of the form in which these are produced they are merely ...

Marie Brown, Warwick B. Dunn, David I. Ellis, Royston Goodacre, Julia Handl… in Metabolomics (2005)

Article

Analytical precision, biological variation, and mathematical normalization in high data density metabolomics

Metabolic serotypes sensitive to caloric intake may enable sera metabolomic profiles to validate epidemiological parameters and predict disease risk in humans. This long-range goal is complicated by the lack o...

Yevgeniya I. Shurubor, Ugo Paolucci, Boris F. Krasnikov, Wayne R. Matson… in Metabolomics (2005)

Article

Profiling microbial metabolomes: what do we stand to gain?

Microbes are the most metabolically diverse living forms on earth, capable of occupying every niche imaginable. There is a wealth of knowledge to be gained by studying this diversity and the complexities of mi...

Seetharaman Vaidyanathan in Metabolomics (2005)

Article

Metabolomics – the way forward

Royston Goodacre in Metabolomics (2005)

Article

The origin of correlations in metabolomics data

A phenomenon observed earlier in the development of metabolomics as a systems biology methodology, consists of a small but significant number of metabolites whose levels are highly correlated between biologica...

Diogo Camacho, Alberto de la Fuente, Pedro Mendes in Metabolomics (2005)

Article

Relative contribution of specific sources of systematic errors and analytical imprecision to metabolite analysis by HPLC–ECD

Objective interpretation of metabolomics data requires understanding both analytical and biological measurement errors. Here we address analytical measurement errors, the sources of these errors, and how this ...

Yevgeniya I. Shurubor, Wayne R. Matson, Rolf J. Martin, Bruce S. Kristal in Metabolomics (2005)

Article

Metabolite profiling of Arabidopsis thaliana (L.) plants transformed with an antisense chalcone synthase gene

A metabolite profiling study has been carried out on Arabidopsis thaliana (L.) Heynh. ecotype Wassilewskija and a series of transgenic lines of the ecotype transformed with a CHS (chalcone synthase) antisense con...

Gwénaëlle Le Gall, Stine B. Metzdorff, Jan Pedersen, Richard N. Bennett… in Metabolomics (2005)

Article

A non-directed approach to the differential analysis of multiple LC–MS-derived metabolic profiles

An essential element of any strategy for non-targeted metabolomics analysis of complex biological extracts is the capacity to perform comparisons between large numbers of samples. As the most widely used techn...

O. Vorst, C. H. R. de Vos, A. Lommen, R. V. Staps, R. G. F. Visser… in Metabolomics (2005)

Article

Characterizing the metabolic actions of natural stresses in the California red abalone, Haliotis rufescens using ¹H NMR metabolomics

Withering syndrome in California red abalone (Haliotis rufescens) is caused by the Rickettsiales-like prokaryote (WS-RLP) Candidatus Xenohaliotis californiensis. WS-RLP infection is not sufficient to cause wither...

E. S. Rosenblum, M. R. Viant, B. M. Braid, J. D. Moore, C. S. Friedman… in Metabolomics (2005)

Article

Qualitative high field ¹H-NMR spectroscopy for the characterization of endogenous metabolites in earthworms with biochemical biomarker potential

This study was designed to provide a database of the endogenous metabolites in earthworm extracts of the species, Eisenia veneta and Lumbricus terrestris by high resolution ¹H-NMR spectroscopy in view of identify...

E. M. Lenz, J. M. Weeks, J. C. Lindon, D. Osborn, J. K. Nicholson in Metabolomics (2005)

Article

Correlative GC-TOF-MS-based metabolite profiling and LC-MS-based protein profiling reveal time-related systemic regulation of metabolite–protein networks and improve pattern recognition for multiple biomarker selection

A novel approach is presented combining quantitative metabolite and protein data and multivariate statistics for the analysis of time-related regulatory effects of plant metabolism at a systems level. For the ...

Katja Morgenthal, Stefanie Wienkoop, Matthias Scholz, Joachim Selbig… in Metabolomics (2005)

Article

Metabolomic analysis and signatures in motor neuron disease

Motor neuron diseases (MND) are a heterogeneous group of disorders that includes amyotrophic lateral sclerosis (ALS) and result in death of motor neurons. These diseases may produce characteristic perturbation...

Steve Rozen, Merit E. Cudkowicz, Mikhail Bogdanov, Wayne R. Matson… in Metabolomics (2005)

Article

Evaluation of automated electrospray-TOF mass spectrometryfor metabolic fingerprinting of the plant metabolome

Metabolic fingerprinting is increasingly employed in microbial and plant metabolomics. Identification and evaluation of analytical factors that influence mass spectra produced with automated electrospray time ...

W. B. Dunn, S. Overy, W. P. Quick in Metabolomics (2005)

Article

NMR-derived developmental metabolic trajectories: an approach for visualizing the toxic actions of trichloroethylene during embryogenesis

Fish embryo toxicity tests for chemical risk assessment have traditionally been based upon non-specific endpoints including morphological abnormalities, hatching success, and mortality. Here we extend the appl...

Mark R. Viant, Jacob G. Bundy, Christopher A. Pincetich, Jeffrey S. de Ropp… in Metabolomics (2005)

Article

NEW IN 2005!

Royston Goodacre in Metabolomics (2005)