29 Result(s)

Article

Neutrophil-derived migrasomes are an essential part of the coagulation system

Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...

Dong Jiang, Lin Jiao, Qing Li, Renxiang **e, Haohao Jia, ShiHui Wang… in Nature Cell Biology (2024)

Article

Correction: Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu… in Cell Death & Disease (2024)

Article

Correction: Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

Chan **ang, Min Zhang, Zhanxian Shang, Shengnan Chen, Jikai Zhao… in Cell Death & Disease (2024)

Article

Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte

Psoriasis is a common and recurrent inflammatory skin disease characterized by inflammatory cells infiltration of the dermis and excessive proliferation, reduced apoptosis, and abnormal keratosis of the epider...

Zhiqin Fang, Yutong Wang, Bo Huang, **ang Chen, Rundong Jiang… in Cell Death & Disease (2023)

Article

Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

An immunosuppressive microenvironment enriched with regulatory CD4⁺ T lymphocytes (Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular mechanism underlyin...

Chan **ang, Min Zhang, Zhanxian Shang, Shengnan Chen, Jikai Zhao… in Cell Death & Disease (2023)

Article

Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Synergies of transcription factors, chromatin modifiers and their target genes are vital for cell fate determination in human cancer. Although the importance of numerous epigenetic machinery for regulating gli...

Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu… in Cell Death & Disease (2022)

Article

hACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants

Junli Liu, Qi Chen, Shumin Yang, Ying Li, Yang Dou, Yong-Qiang Deng… in Cell Discovery (2021)

Article

Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression

Myocarditis (MC) is a common, potentially life-threatening inflammatory disease of the myocardium. A growing body of evidence has shown that mitogen-activated protein kinase 14 (MAPK14) participates in the pat...

Li Zhang, Bo Han, Huanlong Liu, **g Wang, **nxin Feng, Wei Sun… in Cell Death & Disease (2021)

Article

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis. Evidences suggest that berb...

**ngxing Li, Chunyan Su, Zhibo Jiang, Yuxin Yang, Yue Zhang… in npj Biofilms and Microbiomes (2021)

Article

The ATPase Pontin is a key cell cycle regulator by amplifying E2F1 transcription response in glioma

Pontin (RUVBL1) is a highly conserved ATPase of the AAA + (ATPases Associated with various cellular Activities) superfamily and is implicated in various biological processes crucial for oncogenesis. Its overex...

Run Wang, Xuebing Li, Cuiyun Sun, Lin Yu, Dan Hua, Cuijuan Shi… in Cell Death & Disease (2021)

Article

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic an...

Hang** Yao, Yao Sun, Yong-Qiang Deng, Nan Wang, Yongcong Tan… in Cell Research (2021)

Article

3D landscape of Hepatitis B virus interactions with human chromatins

Hepatitis B viral (HBV) DNAs, including covalently closed circular DNA (cccDNA) and integrated HBV DNA forms, are considered to be primary contributors to the development and progression of HBV-associated live...

Bo Yang, Boyuan Li, Liyang Jia, Yongpeng Jiang, **n Wang, Shaodong Jiang… in Cell Discovery (2020)

Article

Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation

Pei-Gang Wang, Dong-Jiang Tang, Zhan Hua, Zai Wang, **g An in Cell Discovery (2020)

Article

Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT–qPCR primer–probe sets

The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exemplifies the critical need for accurate and rapid diagnostic assays to prompt clinical and public health interventions. Curr...

Chantal B. F. Vogels, Anderson F. Brito, Anne L. Wyllie… in Nature Microbiology (2020)

Article

miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells

Osteosarcoma (OS) is a malignant bone tumor which occurs mainly in adolescents with frequent pulmonary metastasis and a high mortality rate. Accumulating evidence has indicated that microRNAs (miRNAs) play a v...

Wei Liu, Dongdong Jiang, Fangyi Gong, Yumin Huang, Yongjun Luo… in Cell Death & Disease (2020)

Article

Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma

Epigenetic alteration of tumor suppression gene is one of the most significant indicators in human esophageal squamous cell carcinoma (ESCC). In this study, we identified a novel ESCC hypermethylation biomarker Z...

Dong Jiang, Zhenglei He, Chenji Wang, Yinghui Zhou, Fang Li… in Cell Death & Disease (2018)

Article

Insights into the impact of flhF inactivation on Campylobacter jejuni colonization of chick and mice gut

Campylobacter jejuni (C. jejuni) is a leading cause of foodborne gastroenteritis worldwide. This bacterium lacks many of the classical virulence factors, and flagellum-associated persistent colonization has been ...

Fangzhe Ren, **aofei Li, Haiyan Tang, Qidong Jiang, ** Yun, Lin Fang… in BMC Microbiology (2018)

Article

miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis

Robust proliferation and apoptosis inhibition of tumor cells are responsible for the high mortality and poor outcome of patients with high-grade gliomas. miR-29a/b/c have been reported to be important suppress...

Cuijuan Shi, Chun Rao, Cuiyun Sun, Lin Yu, Xuexia Zhou, Dan Hua… in Cell Death & Disease (2018)

Article

Temperature-controlled thermophilic bacterial communities in hot springs of western Sichuan, China

Ganzi Prefecture in Western China is situated geographically at the transition regions between Tibetan Plateau and Sichuan Basin in a highly tectonically active boundary area between the India and Eurasia plat...

Jie Tang, Yuanmei Liang, Dong Jiang, Liheng Li, Yifan Luo… in BMC Microbiology (2018)

Article

Modeling trophic dependencies and exchanges among insects’ bacterial symbionts in a host-simulated environment

Individual organisms are linked to their communities and ecosystems via metabolic activities. Metabolic exchanges and co-dependencies have long been suggested to have a pivotal role in determining community st...

Itai Opatovsky, Diego Santos-Garcia, Zhepu Ruan, Tamar Lahav, Shany Ofaim… in BMC Genomics (2018)