29 Result(s)

Article

Neutrophil-derived migrasomes are an essential part of the coagulation system

Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...

Dong Jiang, Lin Jiao, Qing Li, Renxiang **e, Haohao Jia, ShiHui Wang… in Nature Cell Biology (2024)

Article

Correction: Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu… in Cell Death & Disease (2024)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: Promotion of osteogenesis in BMSC under hypoxia by ATF4 via the PERK–eIF2α signaling pathway

Yuan Feng, Zhiqi Han, Weidong Jiang… in In Vitro Cellular & Developmental Biology … (2024)

Article

Correction: Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

Chan **ang, Min Zhang, Zhanxian Shang, Shengnan Chen, Jikai Zhao… in Cell Death & Disease (2024)

Article

Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment

Zhidong Jiang, Bo Feng, Yumin Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte

Psoriasis is a common and recurrent inflammatory skin disease characterized by inflammatory cells infiltration of the dermis and excessive proliferation, reduced apoptosis, and abnormal keratosis of the epider...

Zhiqin Fang, Yutong Wang, Bo Huang, **ang Chen, Rundong Jiang… in Cell Death & Disease (2023)

Article

Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

An immunosuppressive microenvironment enriched with regulatory CD4⁺ T lymphocytes (Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular mechanism underlyin...

Chan **ang, Min Zhang, Zhanxian Shang, Shengnan Chen, Jikai Zhao… in Cell Death & Disease (2023)

Article

Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment

Zhidong Jiang, Bo Feng, Yumin Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

Genomic MET amplification and exon 14 skip** are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met in...

Ji Zhou, Xu-Chao Zhang, Shan Xue, Mengdi Dai… in Signal Transduction and Targeted Therapy (2023)

Article

Correction to: Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway Under Hypoxia

Zhiqi Han, Xuan He, Yuan Feng, Weidong Jiang… in Tissue Engineering and Regenerative Medici… (2022)

Article

Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Synergies of transcription factors, chromatin modifiers and their target genes are vital for cell fate determination in human cancer. Although the importance of numerous epigenetic machinery for regulating gli...

Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu… in Cell Death & Disease (2022)

Article

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota

Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in the gut microbiota and treat athe...

Shu-Rong Ma, Qian Tong, Yuan Lin, Li-Bin Pan… in Signal Transduction and Targeted Therapy (2022)

Article

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patie...

**-Lan Zhang, Yu-Huan Li, Lu-Lu Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Circulating cell-free DNA-based methylation patterns for breast cancer diagnosis

Mammography is used to detect breast cancer (BC), but its sensitivity is limited, especially for dense breasts. Circulating cell-free DNA (cfDNA) methylation tests is expected to compensate for the deficiency ...

**anyu Zhang, Dezhi Zhao, Yanling Yin, Ting Yang, Zilong You, Dalin Li… in npj Breast Cancer (2021)

Article

hACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants

Junli Liu, Qi Chen, Shumin Yang, Ying Li, Yang Dou, Yong-Qiang Deng… in Cell Discovery (2021)

Article

Retraction Note to: Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/β-catenin signal pathway

**alei Liu, Lewei Yang, Dong Jiang, Wuzhu Lu, Yongyu Zhang in Cancer Cell International (2021)

Article

Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression

Myocarditis (MC) is a common, potentially life-threatening inflammatory disease of the myocardium. A growing body of evidence has shown that mitogen-activated protein kinase 14 (MAPK14) participates in the pat...

Li Zhang, Bo Han, Huanlong Liu, **g Wang, **nxin Feng, Wei Sun… in Cell Death & Disease (2021)

Article

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine and generates levodopa (l-dopa) w...

Yan Wang, Qian Tong, Shu-Rong Ma… in Signal Transduction and Targeted Therapy (2021)

Article

MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2

Distraction osteogenesis (DO) is a highly efficacious form of reconstructive bone regeneration, but its clinical utility is limited by the prolonged period required for bone consolidation to occur. Understandi...

Weidong Jiang, Peiqi Zhu, Tao Zhang, Fengchun Liao… in Stem Cell Research & Therapy (2021)