43 Result(s)

Article

Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Nucleic acid vaccines have shown promising potency and efficacy for cancer treatment with robust and specific T-cell responses. Improving the immunogenicity of delivered antigens helps to extend therapeutic ef...

Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li… in Molecular Cancer (2024)

Article

Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway

Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery embolism, and other diseases and can lead to local intestinal n...

**ngjie Wang, Tianli Shen, Jie Lian, Kai Deng, Chao Qu, Enmeng Li… in Molecular Medicine (2023)

Article

Epidemiological characteristics and risk factors for cystic and alveolar echinococcosis in China: an analysis of a national population-based field survey

Human cystic and alveolar echinococcosis are neglected tropical diseases that WHO has prioritized for control in recent years. Both diseases impose substantial burdens on public health and the socio-economy in...

Tian Ma, Qian Wang, Mengmeng Hao, Chuizhao Xue, Xu Wang, Shuai Han… in Parasites & Vectors (2023)

Article

Correction: Uncovering the gene regulatory network of type 2 diabetes through multi-omic data integration

Jiachen Liu, Shenghua Liu, Zhaomei Yu, **aorui Qiu… in Journal of Translational Medicine (2023)

Article

Neutralization sensitivity, fusogenicity, and infectivity of Omicron subvariants

The emergence of SARS-CoV-2 Omicron subvariants has raised questions regarding resistance to immunity by natural infection or immunization. We examined the sensitivity of Delta and Omicron subvariants (BA.1, B...

Xue-Jun Wang, Lin Yao, Hong-Yun Zhang, Ka-Li Zhu, **g Zhao… in Genome Medicine (2022)

Article

Uncovering the gene regulatory network of type 2 diabetes through multi-omic data integration

Type 2 diabetes (T2D) onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. This study aims to find out the key drivers an...

Jiachen Liu, Shenghua Liu, Zhaomei Yu, **aorui Qiu… in Journal of Translational Medicine (2022)

Article

Activating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome

Peritoneal adhesions (PAs) are a serious complication of abdominal surgery and negatively affect the quality of life of millions of people worldwide. However, a clear molecular mechanism and a standard therape...

Tianli Shen, Yunhua Wu, **ngjie Wang, Zijun Wang… in Experimental & Molecular Medicine (2022)

Article

Long-term effect of epigenetic modification in plant–microbe interactions: modification of DNA methylation induced by plant growth-promoting bacteria mediates promotion process

Soil microbiomes are considered a cornerstone of the next green revolution, and plant growth-promoting bacteria (PGPB) are critical for microbiome engineering. However, taking plant-beneficial microorganisms f...

Chen Chen, Miao Wang, **gzhi Zhu, Yongwei Tang, Hanchao Zhang, Qiming Zhao… in Microbiome (2022)

Article

Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China

Coronavirus disease 2019 (COVID-19) broke out in December 2019. Due its high morbility and mortality, it is necessary to summarize the clinical characteristics of COVID-19 patients to provide more theoretical ...

Xue-qing Liu, Shan Xue, Jia-bo Xu, Heng Ge, Qing Mao… in Acta Pharmacologica Sinica (2022)

Article

Correction to: Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury

Yuluo Rong, Chengyue Ji, Zhuanghui Wang, Xuhui Ge… in Journal of Neuroinflammation (2021)

Article

Identification of seven novel ferroptosis-related long non-coding RNA signatures as a diagnostic biomarker for acute myeloid leukemia

Ferroptosis is a newly discovered type of programmed cell death that participates in the biological processes of various cancers. However, the mechanism by which ferroptosis modulates acute myeloid leukemia (A...

Zhiyuan Zheng, Wei Wu, Zehang Lin, Shuhan Liu, Qiaoqian Chen… in BMC Medical Genomics (2021)

Article

Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury

Spinal cord injury (SCI) is a severe traumatic disease which causes high disability and mortality rates. The molecular pathological features after spinal cord injury mainly involve the inflammatory response, m...

Yuluo Rong, Chengyue Ji, Zhuanghui Wang, Xuhui Ge… in Journal of Neuroinflammation (2021)

Article

Circulating cell-free DNA-based methylation patterns for breast cancer diagnosis

Mammography is used to detect breast cancer (BC), but its sensitivity is limited, especially for dense breasts. Circulating cell-free DNA (cfDNA) methylation tests is expected to compensate for the deficiency ...

**anyu Zhang, Dezhi Zhao, Yanling Yin, Ting Yang, Zilong You, Dalin Li… in npj Breast Cancer (2021)

Article

Retraction Note to: Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/β-catenin signal pathway

**alei Liu, Lewei Yang, Dong Jiang, Wuzhu Lu, Yongyu Zhang in Cancer Cell International (2021)

Article

Identification and full-genome sequencing of canine kobuvirus in canine fecal samples collected from Anhui Province, eastern China

Canine kobuvirus (CaKoV), a newly described virus, is the causative agent of gastroenteritis in dogs. In this study, 57 fecal samples from dogs with diarrhea in Anhui Province, eastern China, were collected. A...

Yong Wang, Yongqiu Cui, Yeqiu Li, **aopeng Wang, Kankan Yang… in Archives of Virology (2020)

Article

RETRACTED ARTICLE: Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/β-catenin signal pathway

Hepatocellular carcinoma (HCC) is a common malignant tumor in China. Advanced treatment like transcatheter hepatic arterial chemoembolization (TACE) has prolonged the lives of man...

**alei Liu, Lewei Yang, Dong Jiang, Wuzhu Lu, Yongyu Zhang in Cancer Cell International (2020)

Article

Demonstrating Analytical Similarity of Trastuzumab Biosimilar HLX02 to Herceptin^® with a Panel of Sensitive and Orthogonal Methods Including a Novel FcγRIIIa Affinity Chromatography Technology

A biosimilar needs to demonstrate its similarity to the originator reference product (RP) in terms of structural and functional properties as well as nonclinical and clinical outcomes.

Liqi **e, Erhui Zhang, Yanpeng Xu, Wenyuan Gao, Linlin Wang… in BioDrugs (2020)

Article

Quality by Design–Based Assessment for Analytical Similarity of Adalimumab Biosimilar HLX03 to Humira®

Quality by design (QbD) is an efficient but challenging approach for the development of biosimilar due to the complex relationship among process, quality, and efficacy. Here, the analytical similarity of adali...

Erhui Zhang, Liqi **e, Peilan Qin, Lihong Lu, Yanpeng Xu, Wenyuan Gao… in The AAPS Journal (2020)

Article

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano-sized exosomes have shown great potentia...

Wei Liu, Yuluo Rong, Jiaxing Wang, Zheng Zhou, Xuhui Ge… in Journal of Neuroinflammation (2020)

Article

miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells

Accumulating evidence indicates that aberrant microRNA (miRNA) expression contributes to osteosarcoma progression. This study aimed to elucidate the association between miR-624-5p expression and osteosarcoma (...

Yongjun Luo, Wei Liu, Pengyu Tang… in Journal of Experimental & Clinical Cancer … (2019)