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Article
Open AccessBiliary atresia and cholestasis plasma non-targeted metabolomics unravels perturbed metabolic pathways and unveils a diagnostic model for biliary atresia
The clinical diagnosis of biliary atresia (BA) poses challenges, particularly in distinguishing it from cholestasis (CS). Moreover, the prognosis for BA is unfavorable and there is a dearth of effective non-in...
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Article
Open AccessMulti-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis
Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are Philadelphia chromosome-negative myeloproliferative neoplasms. These conditions share overlap** clinical presentations; howe...
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Article
Open AccessCircular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway
Circular RNAs (circRNAs) are a new group of endogenous RNAs recently found to be involved in the development of various diseases, including their confirmed involvement in the progression of several types of ca...
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Article
Open AccessCorrection: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
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Article
Open AccessCirc6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p/TXNIP axis
Circular RNAs (circRNAs) play important roles in cancer progression and metastasis. However, the expression profiles and biological roles of circRNAs in non-small cell lung cancer (NSCLC) remain unclear.
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Article
Open AccessInvestigating the dynamics of water–sand mixing inrush in viscous sand layers: insights from laboratory experiments
The geological hazard of water–sand inrush is a matter of concern for infrastructure construction and resource exploration activities in China, due to the complex interplay between groundwater dynamics and the...
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Article
Open AccessAnalysis of the Trends and Influencing Factors for Postoperative Cough in Patients with Esophageal Cancer Based on Patient-Reported Outcomes
Cough is a common symptom that affects patients’ recovery and quality of life after esophagectomy. This study sought to investigate trends in postoperative cough and the factors that influence cough.
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Article
Open AccessGenomic insights into the seawater adaptation in Cyprinidae
Cyprinidae, the largest fish family, encompasses approximately 367 genera and 3006 species. While they exhibit remarkable adaptability to diverse aquatic environments, it is exceptionally rare to find them in ...
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Article
Open AccessClinical values of different specimen preparation methods for the diagnosis of lung cancer by EBUS-TBNA
EBUS-TBNA has emerged as an important minimally invasive procedure for the diagnosis and staging of lung cancer. Our objective was to evaluate the effect of different specimen preparation from aspirates on the...
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Article
Open AccessAdaptive expansion of ERVK solo-LTRs is associated with Passeriformes speciation events
Endogenous retroviruses (ERVs) are ancient retroviral remnants integrated in host genomes, and commonly deleted through unequal homologous recombination, leaving solitary long terminal repeats (solo-LTRs). Thi...
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Article
Open AccessA qualitative study of Chinese parental perspectives on the causes of Tourette syndrome in children
Parents’ beliefs and attitudes toward their children with Tourette syndrome (TS) influence treatment-seeking behaviors. This study aimed to explore and describe the Chinese parents’ perspectives on the causes ...
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Article
Open AccessIdentifying key antioxidative stress factors regulating Nrf2 in the genioglossus with human umbilical cord mesenchymal stem-cell therapy
Intermittent hypoxia in patients with obstructive sleep apnea (OSA) hypopnea syndrome (OSAHS) is associated with pharyngeal cavity collapse during sleep. The effect of human umbilical cord mesenchymal stem cel...
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Article
Open AccessPHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA
Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Current therapeutic effect is far from satisfaction. Hence, identifying susceptible genes and potential targets is necessary ...
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Article
Open AccessMyeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target
Prostate cancer (CaP) is the most diagnosed cancer in males and the second leading cause of cancer deaths. Patients with localized tumors are generally curable. However, no curative treatment exists for patien...
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Article
Open AccessAntimicrobial resistance crisis: could artificial intelligence be the solution?
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be dev...
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Article
Open AccessGLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis
Glutamate dehydrogenase 1 (GLUD1) is an important enzyme in glutamine metabolism. Previously, we found GLUD1 was down-regulated in tumor tissues of hepatocellular carcinoma (HCC) patients by proteomics study. ...
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Article
Open AccessNeutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine
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Article
Open AccessEfficient Polytelluride Anchoring for Ultralong-Life Potassium Storage: Combined Physical Barrier and Chemisorption in Nanogrid-in-Nanofiber
The hierarchical nanogrid-in-nanofiber-structured dual-type carbon-confined CoTe2 nanodots (CoTe2@NC@NSPCNFs) were synthesized via facile templates and an electrospinning appr...
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Dryland Ecosystem Services and Human Wellbeing in a Changing Environment and Society
The framework of the Global Dryland Ecosystem Programme (Global-DEP) combines the ecosystem service (ES) research paradigm and system dynamics thinking. The core of the framework is the resilience of social-ec...
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Article
Open AccessMorphological and molecular evidence for natural hybridization between Sorbus pohuashanensis and S. discolor (Rosaceae)
In overlap** distribution areas of Sorbus pohuashanensis and S. discolor in North China (Mount Tuoliang, Mount **ling and Mount Baihua), Sorbus individuals were found with pink fruit, which have never been reco...
