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Open AccessGenetically evaluating the causal role of peripheral immune cells in colorectal cancer: a two-sample Mendelian randomization study
Investigating novel therapeutic strategies for colorectal cancer (CRC) is imperative. However, there is limited research on the use of drugs to target peripheral blood immune cells in this context. To address ...
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Article
Inhalable iron redox cycling powered nanoreactor for amplified ferroptosis-apoptosis synergetic therapy of lung cancer
Fenton reaction centered ferroptosis-apoptosis synergetic therapy has emerged as a promising tumor elimination strategy. However, the low intracellular Fenton level and accumulation of therapeutics at the lesi...
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Article
Open AccessOutcomes of patients in nasopharyngeal adenoid cystic carcinoma in the IMRT era: a single-center experience
Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with special biological features. Controversies exist regarding the treatment approach and prognostic factors in the IMRT era. This study aim...
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Article
Molten metal-organic complex to synthesize versatile ultrathin non-layered oxides
Two-dimensional (2D) materials have attracted a great deal of research interest because of their unique electrical, magnetic, optical, mechanical, and catalytic properties for various applications. To date, ho...
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The reformation of catalyst: From a trial-and-error synthesis to rational design
The appropriate catalysts can accelerate the reaction rate and effectively boost the efficient conversion of various molecules, which is of great importance in the study of chemistry, chemical industry, energy...
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α-Cyanostilbene-based Molecule with the Synergistical Mechanisms of AIE, ESIPT and TICT: A New Schiff Base Probe for Selective Detection of Fe3+ and Reversible Response to HCl/NH3 Vapor
We designed and synthesized a new Schiff base probe, which incorporated the salicylaldehyde-analogue α-cyanostilbene and benzophenone hydrazone by the imine linkage. Its chemical structure was verified by FT-I...
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Open AccessAmifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism
Idiopathic pulmonary fibrosis (IPF) is a devastating chronic lung disease characterized by irreversible scarring of the lung parenchyma. Despite various interventions aimed at mitigating several different mole...
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Open AccessTranscriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1β-knockout mice
Acrylamide is an environmental electrophile that has been produced in large amounts for many years. There is concern about the adverse health effects of acrylamide exposure due to its widespread industrial use...
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Open AccessLncRNA-Gm9866 promotes liver fibrosis by activating TGFβ/Smad signaling via targeting Fam98b
The exact mechanism and target molecules of liver fibrosis have remained largely elusive. Here, we investigated the role of long noncoding RNA Gm9866(lncRNA-Gm9866) on liver fibrosis.
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Article
Stably doped graphene transparent electrode with improved light-extraction for efficient flexible organic light-emitting diodes
Graphene-based flexible transparent electrodes (FTEs) are promising candidate materials for develo** next-generation flexible organic light-emitting diodes (OLEDs). However, the quest for high-efficiency OLE...
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Open AccessInteraction analysis of high-risk pathological features on adjuvant chemotherapy survival benefit in stage II colon cancer patients: a multi-center, retrospective study
We aimed to analyze the benefit of adjuvant chemotherapy in high-risk stage II colon cancer patients and the impact of high-risk factors on the prognostic effect of adjuvant chemotherapy.
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Open AccessThe impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery
The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus, the present study was performed to evaluate the effect of sarcopenia on...
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A molecular sieve-containing protective separator to suppress the shuttle effect of redox mediators in lithium-oxygen batteries
Lithium-oxygen (Li-O2) batteries have a great potential in energy storage and conversion due to their ultra-high theoretical specific energy, but their applications are hindered by sluggish redox reaction kinetic...
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Oxidization-induced structural optimization of Ni3Fe-N-C derived from 3D covalent organic framework for high-efficiency and durable oxygen evolution reaction
NiFe composites have been regarded as promising candidates to replace commercial noble-based electrocatalysts for the oxygen evolution reaction (OER). However, their practical applications still suffer from po...
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Solvent sieving separators implement dual electrolyte for high-voltage lithium-metal batteries
Lithium-metal batteries (LMBs) based on high-voltage cathodes would deliver high specific energy density to meet the demand of future energy storage. However, develo** liquid electrolytes with wide electroch...
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Open AccessIdentification of Timm13 protein translocase of the mitochondrial inner membrane as a potential mediator of liver fibrosis based on bioinformatics and experimental verification
To explore the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis.
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Open AccessMinimal-access video-assisted retroperitoneal and/or transperitoneal debridement (VARTD) in the management of infected walled-off pancreatic necrosis with deep extension: initial experience from a prospective single-arm study
The currently preferred minimally invasive approaches have substantially improved outcomes of infected walled-off pancreatic necrosis (iWON). However, iWON with deep extension (iWONde) still poses a tricky cha...
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A triple-enhanced chemodynamic approach based on glucose-powered hybrid nanoreactors for effective bacteria killing
Rapid evolution of multidrug resistance in bacterial pathogens is outpacing the development of new antibiotics, and chemodynamic therapy (CDT) provides an excellent alternative. However, achieving highly effic...
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An oxygen reservoir-irrigated photoimmunotherapy of malignant melanoma
Tumor hypoxia is the pivotal factor limiting the therapeutic efficacy of photodynamic therapy (PDT), and can be partly improved by either the oxygen economizing or the oxygen supplementation strategies. Nevert...
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Open AccessSurvival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts
Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset of stage I patients who are predisposed to high r...