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Article
Resveratrol ameliorates cyprodinil-induced zebrafish cardiac developmental defects as an aryl hydrocarbon receptor antagonist
Cyprodinil, a globally utilized broad-spectrum pyrimidine amine fungicide, has been observed to elicit cardiac abnormality. Resveratrol (RSV), a naturally occurring polyphenolic compound, showcases remarkable ...
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Article
Open AccessClinical and epidemiological characteristics of 96 pediatric human metapneumovirus infections in Henan, China after COVID-19 pandemic: a retrospective analysis
In the aftermath of the COVID-19 pandemic, there has been a surge in human metapneumovirus (HMPV) transmission, surpassing pre-epidemic levels. We aim to elucidate the clinical and epidemiological characterist...
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Article
Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses
Microglia are resident immune cells of the central nervous system and play key roles in brain homeostasis. During anesthesia, microglia increase their dynamic process surveillance and interact more closely wit...
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Article
Open AccessVEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration
Activation of innate immunity in the brain is a prominent feature of Alzheimer’s disease (AD). The present study investigated the regulation of innate immunity by wild-type serum injection in a transgenic AD m...
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Article
Open AccessIdentification and cross-country comparison of students’ test-taking behaviors in selected eTIMSS 2019 countries
Unfavorable test-taking behaviors, such as speededness and disengagement, have long been a validity concern for large-scale low-stakes assessments. Understanding the presence and extent of such behaviors is im...
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Article
Chemogenetic manipulation of CX3CR1+ cells transiently induces hypolocomotion independent of microglia
Chemogenetic approaches using Designer Receptors Exclusively Activated by Designer Drugs (DREADD, a family of engineered GPCRs) were recently employed in microglia. Here, we used Cx3cr1CreER/+:R26hM4Di/+ mice to ...
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Article
Ferrous Oxide Nanoparticles Induced Abnormal Cardiac Development in Zebrafish Through Hypoxia and Ferroptosis
Ferrous oxide nanoparticles(nFeO) have potential applications in biomedicine, industrial processes, and waste water treatment. However, the biocompatibility of nFeO remains uncertain. In this study, we synthes...
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Article
Open AccessFaecal microbiome-based machine learning for multi-class disease diagnosis
Systemic characterisation of the human faecal microbiome provides the opportunity to develop non-invasive approaches in the diagnosis of a major human disease. However, shared microbial signatures across diffe...
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Article
Open AccessRetraction Note to: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0933-7.
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Article
Open AccessThe voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury
Activation of spinal cord microglia contributes to the development of peripheral nerve injury-induced neuropathic pain. However, the molecular mechanisms underlying microglial function in neuropathic pain are ...
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Article
Open AccessThe voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury
Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stres...
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Article
Open AccessThe circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer
Increasing studies have shown that circRNA is closely related to the carcinogenesis and development of many cancers. However, biological functions and the underlying molecular mechanism of circRNAs in triple-n...
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Article
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling
Microglia dynamically survey the brain parenchyma. Microglial processes interact with neuronal elements; however, what role neuronal network activity plays in regulating microglial dynamics is not entirely cle...
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Article
Open AccessRETRACTED ARTICLE: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression
In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human ...
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Article
Open AccessRNAseq analysis of hippocampal microglia after kainic acid-induced seizures
Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well ...
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Article
Open AccessThe GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions
Microglia are known to engage in physical interactions with neurons. However, our understanding of the detailed mechanistic regulation of microglia-neuron interactions is incomplete. Here, using high resolutio...
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Chapter and Conference Paper
Using Sample Weights in Item Response Data Analysis under Complex Sample Designs
Large-scale assessments are often conducted using complex sampling designs that include the stratification of a target population and multi-stage cluster sampling. To address the nested structure of item respo...
