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Article
3D-CEUS/MRI–CEUS fusion imaging vs 2D-CEUS after locoregional therapies for hepatocellular carcinoma: a multicenter prospective study of therapeutic response evaluation
To compare the diagnostic accuracy of 3D contrast-enhanced ultrasound (CEUS)/MRI–CEUS fusion imaging with 2D-CEUS in assessing the response of hepatocellular carcinoma (HCC) to locoregional therapies in a mult...
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Article
Open AccessClinical application of targeted next-generation sequencing in severe pneumonia: a retrospective review
The precise identification of the underlying causes of infectious diseases, such as severe pneumonia, is essential, and the development of next-generation sequencing (NGS) has enhanced the effectiveness of pat...
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Article
Open AccessLiposome-lentivirus for miRNA therapy with molecular mechanism study
Cancer stem cells (CSCs) play a vital role in the occurrence, maintenance, and recurrence of solid tumors. Although, miR-145-5p can inhibit CSCs survival, poor understanding of the underlying mechanisms hamper...
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Article
Open AccessRunx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice
After spinal cord injury, astrocytes undergo a reactive process and form an astroglial scar, which impedes the regeneration of axons. The role of Runx2 in promoting the transformation of astrocytes in the cent...
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Article
Open AccessAnalysis of Jet Blast Distance of a Refined Engine Nozzle Model for Departing Aircraft
To evaluate the influence distance and evolution law of the jet blast under the full thrust state of the aircraft engine, we constructed a refined single-engine nozzle model in this study. Using a specific B73...
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Article
Open AccessAssociation of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study
Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely reported. We aimed to explore the causality between them in this Mendelian randomization ...
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Article
Family language policy in Chinese d/Deaf-parented families with hearing children: the interplay of multi-dimensional factors
As the first study addressing family language policy (FLP) in d/Deaf-parented families in China, the current research explores language ideologies, practices and management held by different members within the...
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Article
Open AccessA novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells
Podoplanin (PDPN) is a highly conserved, mucin-type protein specific to the lymphatic system. Overexpression of PDPN is associated with the progression of various solid tumors, and plays an important roles in ...
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Article
TULAM: trajectory-user linking via attention mechanism
Recently, the application of location-based services (LBS) has become a prevalent means to provide convenience in customers’ everyday lives. However, because massive volumes of location information are collect...
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Article
Cone penetration resistance of CUMT-1 lunar regolith simulant under magnetic-similitude lunar gravity condition
The cone penetration test (CPT) has shown great potential in coming lunar in-situ resource utilization and base construction missions. To investigate the effect of lunar low gravity and special regolith charac...
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Article
Carbon, nitrogen, and phosphorus metabolic relationships and reaction mechanisms in SBBR processes in the plateau habitat
In this study, two laboratory-scale SBBR reactors were established in a plateau habitat. Using high flux sequencing, the SBBR process was compared by natural sediment and autotrophic sludge to characterize the...
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Advisory Editor profile: Daqing Chen
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Open AccessHepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function
Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9+ hepatocytes in response...
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Article
Advances in application of circulating tumor DNA in ovarian cancer
Ovarian cancer is the third most common gynecologic cancer worldwide and has the highest mortality rate among gynecologic cancers. Identifying timely and effective biomarkers at different stages of the disease...
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Article
Object feature selection under high-dimension and few-shot data based on three-way decision
A feature selection method based on three-way decision is proposed to solve the problem of target recognition under high-dimension and few-shot data. The main research results of this paper include the followi...
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Article
Open AccessCntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway
Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk...
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Article
Open AccessLetter to the editor, “Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study”
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Article
Open AccessNetwork evolution of regional brain volumes in young children reflects neurocognitive scores and mother’s education
The maturation of regional brain volumes from birth to preadolescence is a critical developmental process that underlies emerging brain structural connectivity and function. Regulated by genes and environment,...
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Article
Open AccessTranslation and validation of the Chinese ABCD risk questionnaire to evaluate adults’ awareness and knowledge of the risks of cardiovascular diseases
Assessment of health beliefs and risk perception is a critical means to prevent coronary heart disease, but there are few such studies on assessment in the Chinese population. Given the demonstrated value and ...
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Article
Open AccessPFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation
Cancer cells adopt metabolic reprogramming to promote cell survival under metabolic stress. A key regulator of cell metabolism is AMP-activated protein kinase (AMPK) which promotes catabolism while suppresses ...
