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Article
Open AccessPositive pathogens in stool could predict the clinical outcomes of sepsis-associated acute kidney injury in critical ill patient
In this study, we sought to evaluate the influence of positive pathogens in stool (PPS) on clinical outcomes in critical ill patients with Sepsis-associated acute kidney injury (S-AKI) from intensive care unit...
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Chapter and Conference Paper
Topology Optimization of Multi-material Structures Based on Improved BESO Algorithm
The topology optimization of multi-material structures offers a larger design space than single-material structures, displaying promising design potential and application prospects. This paper investigates the...
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Article
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function
Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain. However, the specific mechanisms by which immune cells pr...
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Article
Open AccessCEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids
CCAAT/Enhancer Binding Protein D (CEBPD), a pleiotropic glucocorticoid-responsive transcription factor, modulates inflammatory responses. Of relevance to asthma, expression of CEBPD in airway smooth muscle (ASM) ...
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Article
Open AccessFFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells
Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airwa...
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Article
Open AccessDexamethasone rescues TGF-β1-mediated β2-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells
Glucocorticoids (GCs) and β2-adrenergic receptor (β2AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression in human airway smooth muscle (HASM), thereby attenuating airway inflam...
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Article
Influence of hexapod robot foot shape on sinking considering multibody dynamics
Hexapod robots have attracted attention for their excellent terrain adaptabilities. When a robot walks on soft soil, dynamic subsidence and slippage greatly reduce its walking performance. The influence of foo...
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Article
Adaptive DC interconnection provisioning in distributed all-optical micro-datacenters using holistically SDN orchestration for dynamic access
The metro-embedded datacenter (ME-DC) architecture which is based on micro-DCs (mDC) is introduced and implemented to deliver more flexible services with less access latency. Hierarchical SDN control is employ...
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Article
Design of an index system for deep groundwater management efficiency evaluation: A case study in Tian** City, China
An effective evaluation system can provide specific and practical suggestions to the deep groundwater management. But such kind of evaluation system has not been proposed in China. In this study, an evaluation...
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Article
Development and application of a regional land subsidence model for the plain of Tian**
In this paper, a coupled numerical groundwater and land subsidence model was developed for the Tian** Plain. The model was employed to investigate the groundwater resources and their changes over the last dec...
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Article
Unified support for integrated all-optical multicast and burst amplification in transparent optical network
To better support transparent optical network, we present a novel scalable structure design based on multi-wavelength conversion (MWC) for integrated optical multicast and burst amplification in this paper. We...
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Chapter and Conference Paper
Local Subspace-Based Denoising for Shot Boundary Detection
Shot boundary detection (SBD) has long been an important problem in content based video analyzing. In existing works, researchers proposed kinds of methods to analyze the continuity of video sequence for SBD. ...
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Article
c7E3 Fab inhibits human tumor angiogenesis in a SCID mouse human skin xenograft model
The αvβ3 integrin plays an important role in tumor growth and angiogenesis. Inhibition of this receptor by intact bivalent antibodies has been shown to inhibit angiogenesis and tumor growth. In this study we t...
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Article
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
Shear stress is a fundamental determinant of vascular homeostasis, regulating vascular remodelling, cardiac development and atherogenesis1, but the mechanisms of transduction are poorly understood. Previous work ...
