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Life Sciences
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Article
Open AccessPorcine lung tissue slices: a culture model for PRCV infection and innate immune response investigations
Respiratory coronaviruses (RCoVs) significantly threaten human health, necessitating the development of an ex vivo respiratory culture system for investigating RCoVs infection. Here, we successfully generated ...
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Correction: Metagenomic analysis of soil microbial communities associated with Poa alpigena Lindm in Haixin Mountain, Qinghai Lake
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Open AccessRecurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...
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Open AccessComparative analysis of POD genes and their expression under multiple hormones in Pyrus bretschenedri
Class III peroxidase (POD) enzymes play vital roles in plant development, hormone signaling, and stress responses. Despite extensive research on POD families in various plant species, the knowledge regarding t...
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Open AccessPangenome-Wide Association Study and Transcriptome Analysis Reveal a Novel QTL and Candidate Genes Controlling both Panicle and Leaf Blast Resistance in Rice
Cultivating rice varieties with robust blast resistance is the most effective and economical way to manage the rice blast disease. However, rice blast disease comprises leaf and panicle blast, which are differ...
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Open AccessMFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction
Drug combination therapy is generally more effective than monotherapy in the field of cancer treatment. However, screening for effective synergistic combinations from a wide range of drug combinations is parti...
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Open AccessInfluence of the Cellular Ultrastructure and Enzyme Activity of the Leaf Sheath on Spontaneous Defoliation in Sugarcane
Spontaneous defoliation improves the harvesting efficiency and yield of sugarcane. Here, we investigated the ultrastructural changes and pectinase and cellulase activity in the third, fifth, and seventh leaf s...
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Open AccessComparative analysis of the complete chloroplast genome sequences of four camellia species
Researching the photosynthetic characteristics based on the whole chloroplast genome sequence of Camellia osmantha cv ‘yidan’ is important for improving production. We sequenced and analyzed the chloroplast (cp) ...
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Open AccessDevelopment of a CRISPR-Cas12a based assay for the detection of swine enteric coronaviruses in pig herds in China
Porcine epidemic diarrhea virus (PEDV), Transmissible gastroenteritis virus (TGEV), Porcine deltacoronavirus (PDCoV) and Swine acute diarrhea syndrome coronavirus (SADS-CoV) rank among the most frequently enco...
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Open AccessGene flow and an anomaly zone complicate phylogenomic inference in a rapidly radiated avian family (Prunellidae)
Resolving the phylogeny of rapidly radiating lineages presents a challenge when building the Tree of Life. An Old World avian family Prunellidae (Accentors) comprises twelve species that rapidly diversified at...
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Open AccessData notes on the proteomics of Dendrobium huoshanense under pb treatment
Pb stress has a negative impact on plant growth by interfering with photosynthesis and releasing reactive oxygen species, causing major risks such as heavy metal ion accumulation in the soil matrix. A proteomi...
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Open AccessLong-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines
Cervical cancer (CC) causes more than 311,000 deaths annually worldwide. The integration of human papillomavirus (HPV) is a crucial genetic event that contributes to cervical carcinogenesis. Despite HPV DNA in...
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Open AccessUnraveling two decades of phyllosphere endophytes: tracing research trends and insights through visualized knowledge maps, with emphasis on microbial interactions as emerging frontiers
Phyllosphere endophytes play a critical role in a myriad of biological functions, such as maintaining plant health and overall fitness. They play a determinative role in crop yield and quality by regulating vi...
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Open AccessGOLGA7 is essential for NRAS trafficking from the Golgi to the plasma membrane but not for its palmitoylation
NRAS mutations are most frequently observed in hematological malignancies and are also common in some solid tumors such as melanoma and colon cancer. Despite its pivotal role in oncogenesis, no effective therapie...
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Open AccessDoes arbuscular mycorrhizal fungi inoculation influence soil carbon sequestration?
Whether arbuscular mycorrhizal fungi (AMF) inoculation promotes soil C sequestration is largely unknown. Here, meta-analysis and logistic regression were applied to study the ecological effects of AMF inoculat...
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Open AccessGenomic characterization of Listeria monocytogenes and Listeria innocua isolated from milk and dairy samples in Ethiopia
Listeriosis caused by Listeria monocytogenes often poses a significant threat to vulnerable populations. Dairy products have been implicated in outbreaks of listeriosis worldwide. In Ethiopia, studies have identi...
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Open AccessA Mitochondrial Localized Chaperone Regulator OsBAG6 Functions in Saline-Alkaline Stress Tolerance in Rice
B-cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family genes play prominent roles in regulating plant growth, development, and stress response. Although the molecular mechanism underlying BAG’s response ...
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Open AccessA robust CRISPR interference gene repression system in Vibrio parahaemolyticus
Vibrio parahaemolyticus is a significant cause of seafood-associated gastroenteritis and pestilence in aquaculture worldwide. Despite extensive research, strategies for protein depletion in this pathogen remain l...
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Open AccessThe involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients. The highly conserved ubiquitinat...
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Open AccessFunctional and kinetics of two efficient phenylalanine ammonia lyase from Pyrus bretschneideri
The enzyme phenylalanine ammonia lyase (PAL) controls the transition from primary to secondary metabolism by converting L-phenylalanine (L-Phe) to cinnamic acid. However, the function of PAL in pear plants (Pyrus...
