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**aoyuan **a
Life Sciences
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Article
Metabolic engineering of Escherichia coli to efficiently produce 3-deacyl-2-acyloxyacyl-4′-monophosphoryl-lipid A
3-O-Deacyl-2-O-palmitoyl-4′-monophosphoryl lipid A (MPL) has recently been used in vaccine adjuvant. In this study, an E. coli mutant WZM012 which can effectively produce MPL has been constructed from E. coli MG1...
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Optimization of evaluation method for low nitrogen tolerance in soybean germplasm seedlings
Nitrogen is a critical macro-nutrient for growth and development of soybeans (Glycine max L.). Improving nitrogen use efficiency and develo** low nitrogen tolerance varieties are important approaches to mitigat...
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Metabolic engineering of Corynebacterium glutamicum CGY-PG-304 for promoting gamma-aminobutyric acid production
Gamma-aminobutyric acid is a versatile and non-protein amino acid that plays a significant role in medicine, food, and cosmetics. The synthesis of gamma-aminobutyric acid is restricted by complex metabolic mec...
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IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor characterized by a highly heterogeneous and immunosuppressive tumor microenvironment (TME). The symbiotic interactions between glioblasto...
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Plasma-Derived Exosomal tRF-Phe-GAA-001 and tRF-Gly-GCC-037 as Novel Diagnostic Biomarkers for Cervical Cancer
This study delves into the exploration of exosomal transfer RNA-derived fragments (tRFs) as potential diagnostic markers for cervical cancer (CC). Employing plasma-derived exosomes isolated through ultracentri...
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Open AccessPorcine lung tissue slices: a culture model for PRCV infection and innate immune response investigations
Respiratory coronaviruses (RCoVs) significantly threaten human health, necessitating the development of an ex vivo respiratory culture system for investigating RCoVs infection. Here, we successfully generated ...
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Correction: Metagenomic analysis of soil microbial communities associated with Poa alpigena Lindm in Haixin Mountain, Qinghai Lake
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Open AccessRecurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...
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Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is one of the major causes of death and disability, and hypertensive ICH (HICH) is the most common type of ICH. Currently, the outcomes of HICH patients remain poor after treatme...
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Open AccessComparative analysis of POD genes and their expression under multiple hormones in Pyrus bretschenedri
Class III peroxidase (POD) enzymes play vital roles in plant development, hormone signaling, and stress responses. Despite extensive research on POD families in various plant species, the knowledge regarding t...
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Metagenomic analysis of soil microbial communities associated with Poa alpigena Lindm in Haixin Mountain, Qinghai Lake
To investigate the impact of Poa alpigena Lindm on rhizosphere and bulk soil microorganisms in Haixin Mountain, Qinghai Lake, this study employed metagenomics technology to analyze the microbial communities of th...
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Toll-like receptor activation regulates the paracrine effect of adipose-derived mesenchymal stem cells on reversing osteoarthritic phenotype of chondrocytes
The therapeutic efficacy of intra-articular mesenchymal stem cells (MSCs) injection for patients with osteoarthritis (OA) currently exhibits inconsistency, and the underlying mechanism remains elusive. It has ...
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Open AccessPangenome-Wide Association Study and Transcriptome Analysis Reveal a Novel QTL and Candidate Genes Controlling both Panicle and Leaf Blast Resistance in Rice
Cultivating rice varieties with robust blast resistance is the most effective and economical way to manage the rice blast disease. However, rice blast disease comprises leaf and panicle blast, which are differ...
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Microbial chassis design and engineering for production of gamma-aminobutyric acid
Gamma-aminobutyric acid (GABA) is a non-protein amino acid which is widely applied in agriculture and pharmaceutical additive industries. GABA is synthesized from glutamate through irreversible α-decarboxylati...
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Fabricating Composite Cell Sheets for Wound Healing: Cell Sheets Based on the Communication Between BMSCs and HFSCs Facilitate Full-Thickness Cutaneous Wound Healing
Insufficient angiogenesis and the lack of skin appendages are critical challenges in cutaneous wound healing. Stem cell-fabricated cell sheets have become a promising strategy, but cell sheets constructed by a...
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Dihydroartemisinin inhibits restenosis after balloon angioplasty via circHSPA4/miR-19a-5p axis
Dihydroartemisinin (DHA) inhibits restenosis following balloon angioplasty. However, data on the mechanisms of DHA activity in restenosis remains scant. Here, we investigated the role of circRNAs in mediating ...
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The preferential utilization of hepatic glycogen as energy substrates in largemouth bass (Micropterus salmoides) under short-term starvation
To elucidate the underlying mechanism of the energy metabolism in largemouth bass (Micropterus salmoides), cultured fish (initial body weight: 77.57 ± 0.75 g) in the present study were starved for 0 h, 12 h, 24 h...
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Open AccessMFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction
Drug combination therapy is generally more effective than monotherapy in the field of cancer treatment. However, screening for effective synergistic combinations from a wide range of drug combinations is parti...
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TRIM5 as a promising diagnostic biomarker of hepatocellular carcinoma: integrated analysis and experimental validation
The TRIM family is associated with the membrane, and its involvement in the progression, growth, and development of various cancer types has been researched extensively. However, the role played by the TRIM5 g...
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CRL2APPBP2-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence
Cullin-RING E3 ubiquitin ligases (CRLs), the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells, represent core cellular machinery for executing protein degradation and maintaining proteo...
