-
Article
Oxygen tension modulates cell function in an in vitro three-dimensional glioblastoma tumor model
Hypoxia is a typical feature of the tumor microenvironment, one of the most critical factors affecting cell behavior and tumor progression. However, the lack of tumor models able to precisely emulate natural b...
-
Article
Open AccessClinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study
Sodium bicarbonate (SB) infusion is commonly used to correct metabolic acidosis, but its clinical efficacy remains controversial. This study aims to investigate whether acid–base balance parameters should be a...
-
Article
Open AccessAmphipathic dendritic poly-peptides carrier to deliver antisense oligonucleotides against multi-drug resistant bacteria in vitro and in vivo
Outbreaks of infection due to multidrug-resistant (MDR) bacteria, especially Gram-negative bacteria, have become a global health issue in both hospitals and communities. Antisense oligonucleotides (ASOs) based...
-
Article
Open AccessIntegrated analysis of the chemical-material basis and molecular mechanisms for the classic herbal formula of Lily Bulb and Rehmannia Decoction in alleviating depression
Lily Bulb and Rehmannia Decoction (LBRD), is a traditional Chinese formula that has been shown to be safe and effective against depression; however, its material basis and pharmacological mechanisms remain unk...
-
Article
Open AccessLoop-armed DNA tetrahedron nanoparticles for delivering antisense oligos into bacteria
Antisense oligonucleotides (ASOs) based technology is considered a potential strategy against antibiotic-resistant bacteria; however, a major obstacle to the application of ASOs is how to deliver them into bac...
-
Article
Open AccessOuter membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protei...
-
Article
Open AccessThe antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase
New Delhi metallo-β-lactamase-1 (NDM-1) is the most prevalent type of metallo-β-lactamase and hydrolyzes almost all clinically used β-lactam antibiotics. Here we show that the antimicrobial peptide thanatin di...
-
Article
Open AccessInhibiting PSMα-induced neutrophil necroptosis protects mice with MRSA pneumonia by blocking the agr system
Given its high resistance, enhanced virulence, and high transmissibility, community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia is highly associated with high morbidity and mortalit...
-
Article
Open AccessPyroptosis of Salmonella Typhimurium-infected macrophages was suppressed and elimination of intracellular bacteria from macrophages was promoted by blocking QseC
QseC is a membrane-bound histidine sensor kinase found in Gram-negative pathogens and is involved in the regulation of bacterial virulence. LED209, a QseC-specific inhibitor, significantly inhibits the virulen...
-
Article
Open AccessEffects of Berries Consumption on Cardiovascular Risk Factors: A Meta-analysis with Trial Sequential Analysis of Randomized Controlled Trials
The effects of berries consumption on cardiovascular disease (CVD) risk factors have not been systematically examined. Here, we aimed to conduct a meta-analysis with trial sequential analysis to estimate the e...
-
Article
Open AccessSelective in vivo and in vitro activities of 3,3′-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III
As the persistent resistance of Staphylococcus aureus to available antibiotics is associated with high infection incidence, mortality rate and treatment cost, novel antibacterial agents with innovative therapeuti...
-
Article
Reversion of antibiotic resistance by inhibiting mecA in clinical methicillin-resistant Staphylococci by antisense phosphorothioate oligonucleotide
Methicillin-resistant Staphylococci (MRS), methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) have become a challenging problem in nosocomial infections...
-
Chapter and Conference Paper
Service Adaptability Analysis across Semantics and Behavior Levels Based on Model Transformation
Web service adaptability analysis is a prominent aspect of service adaptation. Current Petri net-based approaches focus on behavior-level service adaptability analysis, lacking of cross-level analysis; Besides...
-
Article
Comparison of microplate and macrodilution methods in time–kill study of new antimicrobial drugs
In consideration of high production costs of new antimicrobial drugs, a more convenient and economical method for time–kill study is urgently required. In the present experiment, we attempted to demonstrate th...
-
Article
Amino-Terminated Generation 2 Poly(amidoamine) Dendrimer as a Potential Broad-Spectrum, Nonresistance-Inducing Antibacterial Agent
The treatment of septicemia caused by antibiotic-resistant bacteria is a great challenge in the clinic. Because traditional antibiotics inevitably induce bacterial resistance, which is responsible for many tre...
-
Article
Restoration of antibiotic susceptibility in fluoroquinolone-resistant Escherichia coli by targeting acrB with antisense phosphorothioate oligonucleotide encapsulated in novel anion liposome
Fluoroquinolone-resistant Escherichia coli (FREC) is one of the leading causes of Gram-negative bacterial infections short of effective antibiotics, thus necessitating development of novel antibacterial agents su...
-
Article
Fabrication and characterization of titanium-matrix composite with 20 vol% hydroxyapatite for use as heavy load-bearing hard tissue replacement
Titanium-matrix composite with 20 vol% HA ceramic was fabricated by hot pressing technique and the microstructure of the composite was studied by transmission electron microscope (TEM). The mechanical and biol...
-
Article
Mechanical and biological properties of hydroxyapatite reinforced with 40 vol. % titanium particles for use as hard tissue replacement
Hydroxyapatite (HA)-based composite reinforced with 40 vol. % Ti particles was fabricated by the optimal technical condition of hot pressing technique. The mechanical and biological properties of the composite...
