6 Result(s)
within
**aowei Fei
Biomedicine
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Article
Open AccessExtracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of ...
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Article
Open AccessHomer1 ameliorates ischemic stroke by inhibiting necroptosis-induced neuronal damage and neuroinflammation
Proinflammatory necroptosis is the main pathological mechanism of ischemic stroke. Homer scaffolding protein 1 (Homer1) is a postsynaptic scaffolding protein that exerts anti-inflammatory effects in most centr...
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Article
Open AccessTRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1
The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, the molecular mechanism underlying the relationsh...
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Article
Open AccessHomer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage
Inflammation induced by intracerebral hemorrhage (ICH) is one of the main causes of the high mortality and poor prognosis of patients with ICH. A1 astrocytes are closely associated with neuroinflammation and n...
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Article
A multi-level similarity measure for the retrieval of the common CT imaging signs of lung diseases
The common CT imaging signs of lung diseases (CISLs) which frequently appear in lung CT images are widely used in the diagnosis of lung diseases. Computer-aided diagnosis (CAD) based on the CISLs can improve r...
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Article
Open AccessThe role of Toll-like receptor 4 in apoptosis of brain tissue after induction of intracerebral hemorrhage
Inflammation and apoptosis caused by intracerebral hemorrhage (ICH) are two important factors that affect patient prognosis and survival. Toll-like receptor 4 (TLR4) triggers activation of the inflammatory pat...
